Case 11-2017 — A 61-Year-Old Woman with Leg Swelling, Back Pain, and Hydronephrosis

A 61-year-old woman presented with a 3-month history of leg swelling and back pain. Imaging revealed a large retroperitoneal mass with hydronephrosis. A diagnostic procedure was performed, and management decisions were made. Presentation of Case Dr. Areej El-Jawahri (Hematology–Oncology): A 61-year-...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:The New England journal of medicine 2017-04, Vol.376 (15), p.1461-1471
Hauptverfasser: Hochberg, Ephraim P, Bierer, Michael F, Winkfield, Karen M, Chen, Yi-Bin, Muse, Victorine V, Louissaint, Abner
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 1471
container_issue 15
container_start_page 1461
container_title The New England journal of medicine
container_volume 376
creator Hochberg, Ephraim P
Bierer, Michael F
Winkfield, Karen M
Chen, Yi-Bin
Muse, Victorine V
Louissaint, Abner
description A 61-year-old woman presented with a 3-month history of leg swelling and back pain. Imaging revealed a large retroperitoneal mass with hydronephrosis. A diagnostic procedure was performed, and management decisions were made. Presentation of Case Dr. Areej El-Jawahri (Hematology–Oncology): A 61-year-old woman was seen in the emergency department of this hospital because of leg swelling and back pain. The patient had been in her usual health until approximately 3 months before this presentation, when mild swelling of her left leg developed. Three days before this presentation, pain in the back, both flanks, and left leg developed and the leg swelling increased. She came to the emergency department of this hospital. The patient reported no trauma, fevers, night sweats, or weight loss. She had arthritis, asthma, hypercholesterolemia, hypertension, and non–insulin-dependent type 2 diabetes . . .
doi_str_mv 10.1056/NEJMcpc1616023
format Article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1887413336</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1887413336</sourcerecordid><originalsourceid>FETCH-LOGICAL-c354t-4565e28ec2b4a1a3439385a37e5ddbd239271991ae3e97fbf6dcbd32a4f37e533</originalsourceid><addsrcrecordid>eNp10MtKxDAUBuAgio6jW5cSEMTFdMzJSdJ2qYM6yngBFXFV0ibVjtOLzRRx50P4hD6JHWcUFDybbL78nPMTsgWsD0yq_Yujs_OkSkCBYhyXSAckoicEU8ukwxgPPOGHuEbWnRuzdkCEq2SNB4JxX8kOuR1oZymAxxn49OPtnR5QBd691bV3OTH0rsx1QV-y6SMd2Qd6_WInk6x46NFDnTzRK50VPaoLQ4evpi4LWz3WpcvcBllJ9cTZzcXbJbfHRzeDoTe6PDkdHIy8BKWYekIqaXlgEx4LDRoFhhhIjb6VxsSGY8h9CEPQFm3op3GqTBIb5FqkM4PYJXvz3KounxvrplGeuaRdURe2bFwEQeALQETV0p0_dFw2ddFu96VCJX0JrerPVdLe4WqbRlWd5bp-jYBFs8Kj34W3H7YXsU2cW_PDvxtuwe4c5LmLCjvO_0v6BFtXg88</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1887965751</pqid></control><display><type>article</type><title>Case 11-2017 — A 61-Year-Old Woman with Leg Swelling, Back Pain, and Hydronephrosis</title><source>MEDLINE</source><source>New England Journal of Medicine Current</source><source>EZB-FREE-00999 freely available EZB journals</source><source>ProQuest Central UK/Ireland</source><creator>Hochberg, Ephraim P ; Bierer, Michael F ; Winkfield, Karen M ; Chen, Yi-Bin ; Muse, Victorine V ; Louissaint, Abner</creator><contributor>Dudzinski, David M ; Cabot, Richard C ; Rosenberg, Eric S ; Shepard, Jo-Anne O ; Harris, Nancy Lee ; Pierce, Virginia M ; Baggett, Meridale V ; McDonald, Emily K ; Ebeling, Sally H ; Sgroi, Dennis C ; Shepard, Jo-Anne O. ; Ebeling, Sally H. ; Dudzinski, David M. ; Pierce, Virginia M. ; Baggett, Meridale V. ; Sgroi, Dennis C. ; Rosenberg, Eric S. ; McDonald, Emily K. ; Cabot, Richard C.</contributor><creatorcontrib>Hochberg, Ephraim P ; Bierer, Michael F ; Winkfield, Karen M ; Chen, Yi-Bin ; Muse, Victorine V ; Louissaint, Abner ; Dudzinski, David M ; Cabot, Richard C ; Rosenberg, Eric S ; Shepard, Jo-Anne O ; Harris, Nancy Lee ; Pierce, Virginia M ; Baggett, Meridale V ; McDonald, Emily K ; Ebeling, Sally H ; Sgroi, Dennis C ; Shepard, Jo-Anne O. ; Ebeling, Sally H. ; Dudzinski, David M. ; Pierce, Virginia M. ; Baggett, Meridale V. ; Sgroi, Dennis C. ; Rosenberg, Eric S. ; McDonald, Emily K. ; Cabot, Richard C.</creatorcontrib><description>A 61-year-old woman presented with a 3-month history of leg swelling and back pain. Imaging revealed a large retroperitoneal mass with hydronephrosis. A diagnostic procedure was performed, and management decisions were made. Presentation of Case Dr. Areej El-Jawahri (Hematology–Oncology): A 61-year-old woman was seen in the emergency department of this hospital because of leg swelling and back pain. The patient had been in her usual health until approximately 3 months before this presentation, when mild swelling of her left leg developed. Three days before this presentation, pain in the back, both flanks, and left leg developed and the leg swelling increased. She came to the emergency department of this hospital. The patient reported no trauma, fevers, night sweats, or weight loss. She had arthritis, asthma, hypercholesterolemia, hypertension, and non–insulin-dependent type 2 diabetes . . .</description><identifier>ISSN: 0028-4793</identifier><identifier>EISSN: 1533-4406</identifier><identifier>DOI: 10.1056/NEJMcpc1616023</identifier><identifier>PMID: 28402765</identifier><language>eng</language><publisher>United States: Massachusetts Medical Society</publisher><subject>Abdomen ; Alzheimer's disease ; Back pain ; Back Pain - etiology ; Biopsy ; Blood pressure ; Breast cancer ; Cardiovascular disease ; Case reports ; Diabetes ; Diagnosis, Differential ; Edema - etiology ; Female ; Hematopoietic Stem Cell Transplantation ; Humans ; Hydronephrosis - etiology ; Hypertension ; Leg ; Lymphadenopathy ; Lymphatic system ; Lymphoma, Follicular - complications ; Lymphoma, Follicular - diagnosis ; Lymphoma, Follicular - pathology ; Lymphoma, Follicular - therapy ; Middle Aged ; Pain ; Retroperitoneal Neoplasms - complications ; Retroperitoneal Neoplasms - diagnosis ; Retroperitoneal Neoplasms - pathology ; Tomography, X-Ray Computed ; Womens health</subject><ispartof>The New England journal of medicine, 2017-04, Vol.376 (15), p.1461-1471</ispartof><rights>Copyright © 2017 Massachusetts Medical Society. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c354t-4565e28ec2b4a1a3439385a37e5ddbd239271991ae3e97fbf6dcbd32a4f37e533</citedby><cites>FETCH-LOGICAL-c354t-4565e28ec2b4a1a3439385a37e5ddbd239271991ae3e97fbf6dcbd32a4f37e533</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.nejm.org/doi/pdf/10.1056/NEJMcpc1616023$$EPDF$$P50$$Gmms$$H</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/1887965751?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>309,310,314,776,780,785,786,2745,2746,23910,23911,25119,26082,27903,27904,52360,54042,64361,64363,64365,72215</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28402765$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Dudzinski, David M</contributor><contributor>Cabot, Richard C</contributor><contributor>Rosenberg, Eric S</contributor><contributor>Shepard, Jo-Anne O</contributor><contributor>Harris, Nancy Lee</contributor><contributor>Pierce, Virginia M</contributor><contributor>Baggett, Meridale V</contributor><contributor>McDonald, Emily K</contributor><contributor>Ebeling, Sally H</contributor><contributor>Sgroi, Dennis C</contributor><contributor>Shepard, Jo-Anne O.</contributor><contributor>Ebeling, Sally H.</contributor><contributor>Dudzinski, David M.</contributor><contributor>Pierce, Virginia M.</contributor><contributor>Baggett, Meridale V.</contributor><contributor>Sgroi, Dennis C.</contributor><contributor>Rosenberg, Eric S.</contributor><contributor>McDonald, Emily K.</contributor><contributor>Cabot, Richard C.</contributor><creatorcontrib>Hochberg, Ephraim P</creatorcontrib><creatorcontrib>Bierer, Michael F</creatorcontrib><creatorcontrib>Winkfield, Karen M</creatorcontrib><creatorcontrib>Chen, Yi-Bin</creatorcontrib><creatorcontrib>Muse, Victorine V</creatorcontrib><creatorcontrib>Louissaint, Abner</creatorcontrib><title>Case 11-2017 — A 61-Year-Old Woman with Leg Swelling, Back Pain, and Hydronephrosis</title><title>The New England journal of medicine</title><addtitle>N Engl J Med</addtitle><description>A 61-year-old woman presented with a 3-month history of leg swelling and back pain. Imaging revealed a large retroperitoneal mass with hydronephrosis. A diagnostic procedure was performed, and management decisions were made. Presentation of Case Dr. Areej El-Jawahri (Hematology–Oncology): A 61-year-old woman was seen in the emergency department of this hospital because of leg swelling and back pain. The patient had been in her usual health until approximately 3 months before this presentation, when mild swelling of her left leg developed. Three days before this presentation, pain in the back, both flanks, and left leg developed and the leg swelling increased. She came to the emergency department of this hospital. The patient reported no trauma, fevers, night sweats, or weight loss. She had arthritis, asthma, hypercholesterolemia, hypertension, and non–insulin-dependent type 2 diabetes . . .</description><subject>Abdomen</subject><subject>Alzheimer's disease</subject><subject>Back pain</subject><subject>Back Pain - etiology</subject><subject>Biopsy</subject><subject>Blood pressure</subject><subject>Breast cancer</subject><subject>Cardiovascular disease</subject><subject>Case reports</subject><subject>Diabetes</subject><subject>Diagnosis, Differential</subject><subject>Edema - etiology</subject><subject>Female</subject><subject>Hematopoietic Stem Cell Transplantation</subject><subject>Humans</subject><subject>Hydronephrosis - etiology</subject><subject>Hypertension</subject><subject>Leg</subject><subject>Lymphadenopathy</subject><subject>Lymphatic system</subject><subject>Lymphoma, Follicular - complications</subject><subject>Lymphoma, Follicular - diagnosis</subject><subject>Lymphoma, Follicular - pathology</subject><subject>Lymphoma, Follicular - therapy</subject><subject>Middle Aged</subject><subject>Pain</subject><subject>Retroperitoneal Neoplasms - complications</subject><subject>Retroperitoneal Neoplasms - diagnosis</subject><subject>Retroperitoneal Neoplasms - pathology</subject><subject>Tomography, X-Ray Computed</subject><subject>Womens health</subject><issn>0028-4793</issn><issn>1533-4406</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp10MtKxDAUBuAgio6jW5cSEMTFdMzJSdJ2qYM6yngBFXFV0ibVjtOLzRRx50P4hD6JHWcUFDybbL78nPMTsgWsD0yq_Yujs_OkSkCBYhyXSAckoicEU8ukwxgPPOGHuEbWnRuzdkCEq2SNB4JxX8kOuR1oZymAxxn49OPtnR5QBd691bV3OTH0rsx1QV-y6SMd2Qd6_WInk6x46NFDnTzRK50VPaoLQ4evpi4LWz3WpcvcBllJ9cTZzcXbJbfHRzeDoTe6PDkdHIy8BKWYekIqaXlgEx4LDRoFhhhIjb6VxsSGY8h9CEPQFm3op3GqTBIb5FqkM4PYJXvz3KounxvrplGeuaRdURe2bFwEQeALQETV0p0_dFw2ddFu96VCJX0JrerPVdLe4WqbRlWd5bp-jYBFs8Kj34W3H7YXsU2cW_PDvxtuwe4c5LmLCjvO_0v6BFtXg88</recordid><startdate>20170413</startdate><enddate>20170413</enddate><creator>Hochberg, Ephraim P</creator><creator>Bierer, Michael F</creator><creator>Winkfield, Karen M</creator><creator>Chen, Yi-Bin</creator><creator>Muse, Victorine V</creator><creator>Louissaint, Abner</creator><general>Massachusetts Medical Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0TZ</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K0Y</scope><scope>LK8</scope><scope>M0R</scope><scope>M0T</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2P</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20170413</creationdate><title>Case 11-2017 — A 61-Year-Old Woman with Leg Swelling, Back Pain, and Hydronephrosis</title><author>Hochberg, Ephraim P ; Bierer, Michael F ; Winkfield, Karen M ; Chen, Yi-Bin ; Muse, Victorine V ; Louissaint, Abner</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c354t-4565e28ec2b4a1a3439385a37e5ddbd239271991ae3e97fbf6dcbd32a4f37e533</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Abdomen</topic><topic>Alzheimer's disease</topic><topic>Back pain</topic><topic>Back Pain - etiology</topic><topic>Biopsy</topic><topic>Blood pressure</topic><topic>Breast cancer</topic><topic>Cardiovascular disease</topic><topic>Case reports</topic><topic>Diabetes</topic><topic>Diagnosis, Differential</topic><topic>Edema - etiology</topic><topic>Female</topic><topic>Hematopoietic Stem Cell Transplantation</topic><topic>Humans</topic><topic>Hydronephrosis - etiology</topic><topic>Hypertension</topic><topic>Leg</topic><topic>Lymphadenopathy</topic><topic>Lymphatic system</topic><topic>Lymphoma, Follicular - complications</topic><topic>Lymphoma, Follicular - diagnosis</topic><topic>Lymphoma, Follicular - pathology</topic><topic>Lymphoma, Follicular - therapy</topic><topic>Middle Aged</topic><topic>Pain</topic><topic>Retroperitoneal Neoplasms - complications</topic><topic>Retroperitoneal Neoplasms - diagnosis</topic><topic>Retroperitoneal Neoplasms - pathology</topic><topic>Tomography, X-Ray Computed</topic><topic>Womens health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hochberg, Ephraim P</creatorcontrib><creatorcontrib>Bierer, Michael F</creatorcontrib><creatorcontrib>Winkfield, Karen M</creatorcontrib><creatorcontrib>Chen, Yi-Bin</creatorcontrib><creatorcontrib>Muse, Victorine V</creatorcontrib><creatorcontrib>Louissaint, Abner</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Pharma and Biotech Premium PRO</collection><collection>Nursing &amp; Allied Health Database</collection><collection>Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>eLibrary</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>New England Journal of Medicine</collection><collection>ProQuest Biological Science Collection</collection><collection>Consumer Health Database</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>Research Library</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing &amp; Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>The New England journal of medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hochberg, Ephraim P</au><au>Bierer, Michael F</au><au>Winkfield, Karen M</au><au>Chen, Yi-Bin</au><au>Muse, Victorine V</au><au>Louissaint, Abner</au><au>Dudzinski, David M</au><au>Cabot, Richard C</au><au>Rosenberg, Eric S</au><au>Shepard, Jo-Anne O</au><au>Harris, Nancy Lee</au><au>Pierce, Virginia M</au><au>Baggett, Meridale V</au><au>McDonald, Emily K</au><au>Ebeling, Sally H</au><au>Sgroi, Dennis C</au><au>Shepard, Jo-Anne O.</au><au>Ebeling, Sally H.</au><au>Dudzinski, David M.</au><au>Pierce, Virginia M.</au><au>Baggett, Meridale V.</au><au>Sgroi, Dennis C.</au><au>Rosenberg, Eric S.</au><au>McDonald, Emily K.</au><au>Cabot, Richard C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Case 11-2017 — A 61-Year-Old Woman with Leg Swelling, Back Pain, and Hydronephrosis</atitle><jtitle>The New England journal of medicine</jtitle><addtitle>N Engl J Med</addtitle><date>2017-04-13</date><risdate>2017</risdate><volume>376</volume><issue>15</issue><spage>1461</spage><epage>1471</epage><pages>1461-1471</pages><issn>0028-4793</issn><eissn>1533-4406</eissn><abstract>A 61-year-old woman presented with a 3-month history of leg swelling and back pain. Imaging revealed a large retroperitoneal mass with hydronephrosis. A diagnostic procedure was performed, and management decisions were made. Presentation of Case Dr. Areej El-Jawahri (Hematology–Oncology): A 61-year-old woman was seen in the emergency department of this hospital because of leg swelling and back pain. The patient had been in her usual health until approximately 3 months before this presentation, when mild swelling of her left leg developed. Three days before this presentation, pain in the back, both flanks, and left leg developed and the leg swelling increased. She came to the emergency department of this hospital. The patient reported no trauma, fevers, night sweats, or weight loss. She had arthritis, asthma, hypercholesterolemia, hypertension, and non–insulin-dependent type 2 diabetes . . .</abstract><cop>United States</cop><pub>Massachusetts Medical Society</pub><pmid>28402765</pmid><doi>10.1056/NEJMcpc1616023</doi><tpages>11</tpages></addata></record>
fulltext fulltext
identifier ISSN: 0028-4793
ispartof The New England journal of medicine, 2017-04, Vol.376 (15), p.1461-1471
issn 0028-4793
1533-4406
language eng
recordid cdi_proquest_miscellaneous_1887413336
source MEDLINE; New England Journal of Medicine Current; EZB-FREE-00999 freely available EZB journals; ProQuest Central UK/Ireland
subjects Abdomen
Alzheimer's disease
Back pain
Back Pain - etiology
Biopsy
Blood pressure
Breast cancer
Cardiovascular disease
Case reports
Diabetes
Diagnosis, Differential
Edema - etiology
Female
Hematopoietic Stem Cell Transplantation
Humans
Hydronephrosis - etiology
Hypertension
Leg
Lymphadenopathy
Lymphatic system
Lymphoma, Follicular - complications
Lymphoma, Follicular - diagnosis
Lymphoma, Follicular - pathology
Lymphoma, Follicular - therapy
Middle Aged
Pain
Retroperitoneal Neoplasms - complications
Retroperitoneal Neoplasms - diagnosis
Retroperitoneal Neoplasms - pathology
Tomography, X-Ray Computed
Womens health
title Case 11-2017 — A 61-Year-Old Woman with Leg Swelling, Back Pain, and Hydronephrosis
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-26T17%3A04%3A36IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Case%2011-2017%20%E2%80%94%20A%2061-Year-Old%20Woman%20with%20Leg%20Swelling,%20Back%20Pain,%20and%20Hydronephrosis&rft.jtitle=The%20New%20England%20journal%20of%20medicine&rft.au=Hochberg,%20Ephraim%20P&rft.date=2017-04-13&rft.volume=376&rft.issue=15&rft.spage=1461&rft.epage=1471&rft.pages=1461-1471&rft.issn=0028-4793&rft.eissn=1533-4406&rft_id=info:doi/10.1056/NEJMcpc1616023&rft_dat=%3Cproquest_cross%3E1887413336%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1887965751&rft_id=info:pmid/28402765&rfr_iscdi=true