Ontogenic differences in human liver 4-hydroxynonenal detoxification are associated with in vitro injury to fetal hematopoietic stem cells

4-hydroxynonenal (4HNE) is a highly mutagenic and cytotoxic α,β-unsaturated aldehyde that can be produced in utero during transplacental exposure to prooxidant compounds. Cellular protection against 4HNE injury is provided by alcohol dehydrogenases (ADH), aldehyde reductases (ALRD), aldehyde dehydro...

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Veröffentlicht in:	Toxicology and applied pharmacology 2003-09, Vol.191 (2), p.95-106
Hauptverfasser:	Gardner, James L, Doi, Adriana M, Pham, Robert T, Huisden, Christiaan M, Gallagher, Evan P
Format:	Artikel
Sprache:	eng
Schlagworte:	4-Hydroxynon-2-enal metabolism Adult Aldehydes - metabolism Biological and medical sciences Cell Survival - drug effects Cytosol - metabolism Fetus - drug effects Fetus - metabolism General aspects. Methods Hematopoietic stem cells Hematopoietic Stem Cells - drug effects Human liver Humans In Vitro Techniques Inactivation, Metabolic Liver - cytology Liver - drug effects Liver - metabolism Medical sciences Ontogeny Toxicology
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