Histological features of malignancy correlate with growth patterns and patient outcome in lung adenocarcinoma
Aims Until the launch of the International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society adenocarcinoma classification in 2011, there were no uniform histological grading criteria for pulmonary adenocarcinomas. The current classification highlights t...
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| Veröffentlicht in: | Histopathology 2017-09, Vol.71 (3), p.425-436 |
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| creator | Mäkinen, Johanna M Laitakari, Kirsi Johnson, Shirley Mäkitaro, Riitta Bloigu, Risto Pääkkö, Paavo Lappi‐Blanco, Elisa Kaarteenaho, Riitta |
| description | Aims
Until the launch of the International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society adenocarcinoma classification in 2011, there were no uniform histological grading criteria for pulmonary adenocarcinomas. The current classification highlights the prognostic importance of the various histological growth patterns observed in these morphologically heterogeneous neoplasias. In this study, we aimed to evaluate the classic histological parameters of malignancy in correlation with the growth patterns and patient outcomes in a series of 112 surgically operated stage I–IV lung adenocarcinomas.
Methods and results
Architectural growth pattern analysis was performed according to the current adenocarcinoma classification. Histological features including, for example, nuclear atypia, mitotic activity, tumour necrosis, and different patterns of invasion were assessed and correlated statistically with the architecture and the clinical data. A solid predominant histology was associated with increased levels of atypia (P = 0.027), mitotic activity (P |
| doi_str_mv | 10.1111/his.13236 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1887055098</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1927443509</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3536-379aa57b181004c227c9af32d4b8c5dc1e1e9d23d280d26babaee73651a002333</originalsourceid><addsrcrecordid>eNp10U1LHTEUBuBQLPVqu_APSMCNXYzmYzIfSxHtFYQu2q7DmcyZaySTXJMMl_vvG3uti0KzOQQeXpLzEnLG2RUv5_rJpisuhWw-kBWXjaqEUv0RWTHJ-orxpj0mJyk9M8ZbKcQnciy6mnHViRWZ1zbl4MLGGnB0QshLxETDRGdwduPBmz01IUZ0kJHubH6imxh2ZWwhZ4w-UfDj68WizzQs2YQZqfXULX5DYUQfDERjfZjhM_k4gUv45W2ekl_3dz9v19Xj928PtzePlZFKNpVsewDVDrzjjNVGiNb0MEkx1kNn1Gg4cuxHIUfRsVE0AwyA2JaPc2BMSClPyeUhdxvDy4Ip69kmg86Bx7AkzbuuZUqxviv04h_6HJboy-s070Vb17Kwor4elIkhpYiT3kY7Q9xrzvRrB7p0oP90UOz5W-IyzDi-y79LL-D6AHbW4f7_SXr98OMQ-RuQHZFW</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1927443509</pqid></control><display><type>article</type><title>Histological features of malignancy correlate with growth patterns and patient outcome in lung adenocarcinoma</title><source>MEDLINE</source><source>Access via Wiley Online Library</source><creator>Mäkinen, Johanna M ; Laitakari, Kirsi ; Johnson, Shirley ; Mäkitaro, Riitta ; Bloigu, Risto ; Pääkkö, Paavo ; Lappi‐Blanco, Elisa ; Kaarteenaho, Riitta</creator><creatorcontrib>Mäkinen, Johanna M ; Laitakari, Kirsi ; Johnson, Shirley ; Mäkitaro, Riitta ; Bloigu, Risto ; Pääkkö, Paavo ; Lappi‐Blanco, Elisa ; Kaarteenaho, Riitta</creatorcontrib><description>Aims
Until the launch of the International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society adenocarcinoma classification in 2011, there were no uniform histological grading criteria for pulmonary adenocarcinomas. The current classification highlights the prognostic importance of the various histological growth patterns observed in these morphologically heterogeneous neoplasias. In this study, we aimed to evaluate the classic histological parameters of malignancy in correlation with the growth patterns and patient outcomes in a series of 112 surgically operated stage I–IV lung adenocarcinomas.
Methods and results
Architectural growth pattern analysis was performed according to the current adenocarcinoma classification. Histological features including, for example, nuclear atypia, mitotic activity, tumour necrosis, and different patterns of invasion were assessed and correlated statistically with the architecture and the clinical data. A solid predominant histology was associated with increased levels of atypia (P = 0.027), mitotic activity (P < 0.001), necrosis (P < 0.001), and lymphovascular invasion (P = 0.001), and a non‐predominant solid pattern was associated with intra‐alveolar tumour spread (P = 0.004). The presence of a non‐predominant lepidic tumour component showed inverse correlations with atypia (P = 0.002), mitotic rate (P = 0.009), and tumour necrosis (P < 0.001). Tumour size (P < 0.001), mitotic activity (P = 0.019), tumour necrosis (P = 0.002), lymphovascular invasion (P = 0.001) and visceral pleural involvement (P = 0.001) were all associated with reduced disease‐specific survival.
Conclusions
The classic histological features of malignancy correlate with tumour architecture and patient outcome, confirming the prognostic value of the growth pattern analysis and questioning the need for a parallel grading system in pulmonary adenocarcinoma.</description><identifier>ISSN: 0309-0167</identifier><identifier>EISSN: 1365-2559</identifier><identifier>DOI: 10.1111/his.13236</identifier><identifier>PMID: 28401582</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Adenocarcinoma ; Adenocarcinoma - classification ; Adenocarcinoma - mortality ; Adenocarcinoma - pathology ; Adenocarcinoma of Lung ; Adult ; Aged ; Alveoli ; Classification ; Disease-Free Survival ; Female ; Gangrene ; Growth patterns ; Histology ; Humans ; Kaplan-Meier Estimate ; lung adenocarcinoma ; Lung cancer ; Lung Neoplasms - classification ; Lung Neoplasms - mortality ; Lung Neoplasms - pathology ; Male ; Malignancy ; Middle Aged ; Necrosis ; Neoplasm Grading ; Prognosis ; Proportional Hazards Models ; Retrospective Studies ; smoking ; Thorax ; Treatment Outcome ; Tumors</subject><ispartof>Histopathology, 2017-09, Vol.71 (3), p.425-436</ispartof><rights>2017 John Wiley & Sons Ltd</rights><rights>2017 John Wiley & Sons Ltd.</rights><rights>Copyright © 2017 John Wiley & Sons Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3536-379aa57b181004c227c9af32d4b8c5dc1e1e9d23d280d26babaee73651a002333</citedby><cites>FETCH-LOGICAL-c3536-379aa57b181004c227c9af32d4b8c5dc1e1e9d23d280d26babaee73651a002333</cites><orcidid>0000-0001-6129-7272</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fhis.13236$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fhis.13236$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28401582$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mäkinen, Johanna M</creatorcontrib><creatorcontrib>Laitakari, Kirsi</creatorcontrib><creatorcontrib>Johnson, Shirley</creatorcontrib><creatorcontrib>Mäkitaro, Riitta</creatorcontrib><creatorcontrib>Bloigu, Risto</creatorcontrib><creatorcontrib>Pääkkö, Paavo</creatorcontrib><creatorcontrib>Lappi‐Blanco, Elisa</creatorcontrib><creatorcontrib>Kaarteenaho, Riitta</creatorcontrib><title>Histological features of malignancy correlate with growth patterns and patient outcome in lung adenocarcinoma</title><title>Histopathology</title><addtitle>Histopathology</addtitle><description>Aims
Until the launch of the International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society adenocarcinoma classification in 2011, there were no uniform histological grading criteria for pulmonary adenocarcinomas. The current classification highlights the prognostic importance of the various histological growth patterns observed in these morphologically heterogeneous neoplasias. In this study, we aimed to evaluate the classic histological parameters of malignancy in correlation with the growth patterns and patient outcomes in a series of 112 surgically operated stage I–IV lung adenocarcinomas.
Methods and results
Architectural growth pattern analysis was performed according to the current adenocarcinoma classification. Histological features including, for example, nuclear atypia, mitotic activity, tumour necrosis, and different patterns of invasion were assessed and correlated statistically with the architecture and the clinical data. A solid predominant histology was associated with increased levels of atypia (P = 0.027), mitotic activity (P < 0.001), necrosis (P < 0.001), and lymphovascular invasion (P = 0.001), and a non‐predominant solid pattern was associated with intra‐alveolar tumour spread (P = 0.004). The presence of a non‐predominant lepidic tumour component showed inverse correlations with atypia (P = 0.002), mitotic rate (P = 0.009), and tumour necrosis (P < 0.001). Tumour size (P < 0.001), mitotic activity (P = 0.019), tumour necrosis (P = 0.002), lymphovascular invasion (P = 0.001) and visceral pleural involvement (P = 0.001) were all associated with reduced disease‐specific survival.
Conclusions
The classic histological features of malignancy correlate with tumour architecture and patient outcome, confirming the prognostic value of the growth pattern analysis and questioning the need for a parallel grading system in pulmonary adenocarcinoma.</description><subject>Adenocarcinoma</subject><subject>Adenocarcinoma - classification</subject><subject>Adenocarcinoma - mortality</subject><subject>Adenocarcinoma - pathology</subject><subject>Adenocarcinoma of Lung</subject><subject>Adult</subject><subject>Aged</subject><subject>Alveoli</subject><subject>Classification</subject><subject>Disease-Free Survival</subject><subject>Female</subject><subject>Gangrene</subject><subject>Growth patterns</subject><subject>Histology</subject><subject>Humans</subject><subject>Kaplan-Meier Estimate</subject><subject>lung adenocarcinoma</subject><subject>Lung cancer</subject><subject>Lung Neoplasms - classification</subject><subject>Lung Neoplasms - mortality</subject><subject>Lung Neoplasms - pathology</subject><subject>Male</subject><subject>Malignancy</subject><subject>Middle Aged</subject><subject>Necrosis</subject><subject>Neoplasm Grading</subject><subject>Prognosis</subject><subject>Proportional Hazards Models</subject><subject>Retrospective Studies</subject><subject>smoking</subject><subject>Thorax</subject><subject>Treatment Outcome</subject><subject>Tumors</subject><issn>0309-0167</issn><issn>1365-2559</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10U1LHTEUBuBQLPVqu_APSMCNXYzmYzIfSxHtFYQu2q7DmcyZaySTXJMMl_vvG3uti0KzOQQeXpLzEnLG2RUv5_rJpisuhWw-kBWXjaqEUv0RWTHJ-orxpj0mJyk9M8ZbKcQnciy6mnHViRWZ1zbl4MLGGnB0QshLxETDRGdwduPBmz01IUZ0kJHubH6imxh2ZWwhZ4w-UfDj68WizzQs2YQZqfXULX5DYUQfDERjfZjhM_k4gUv45W2ekl_3dz9v19Xj928PtzePlZFKNpVsewDVDrzjjNVGiNb0MEkx1kNn1Gg4cuxHIUfRsVE0AwyA2JaPc2BMSClPyeUhdxvDy4Ip69kmg86Bx7AkzbuuZUqxviv04h_6HJboy-s070Vb17Kwor4elIkhpYiT3kY7Q9xrzvRrB7p0oP90UOz5W-IyzDi-y79LL-D6AHbW4f7_SXr98OMQ-RuQHZFW</recordid><startdate>201709</startdate><enddate>201709</enddate><creator>Mäkinen, Johanna M</creator><creator>Laitakari, Kirsi</creator><creator>Johnson, Shirley</creator><creator>Mäkitaro, Riitta</creator><creator>Bloigu, Risto</creator><creator>Pääkkö, Paavo</creator><creator>Lappi‐Blanco, Elisa</creator><creator>Kaarteenaho, Riitta</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-6129-7272</orcidid></search><sort><creationdate>201709</creationdate><title>Histological features of malignancy correlate with growth patterns and patient outcome in lung adenocarcinoma</title><author>Mäkinen, Johanna M ; Laitakari, Kirsi ; Johnson, Shirley ; Mäkitaro, Riitta ; Bloigu, Risto ; Pääkkö, Paavo ; Lappi‐Blanco, Elisa ; Kaarteenaho, Riitta</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3536-379aa57b181004c227c9af32d4b8c5dc1e1e9d23d280d26babaee73651a002333</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adenocarcinoma</topic><topic>Adenocarcinoma - classification</topic><topic>Adenocarcinoma - mortality</topic><topic>Adenocarcinoma - pathology</topic><topic>Adenocarcinoma of Lung</topic><topic>Adult</topic><topic>Aged</topic><topic>Alveoli</topic><topic>Classification</topic><topic>Disease-Free Survival</topic><topic>Female</topic><topic>Gangrene</topic><topic>Growth patterns</topic><topic>Histology</topic><topic>Humans</topic><topic>Kaplan-Meier Estimate</topic><topic>lung adenocarcinoma</topic><topic>Lung cancer</topic><topic>Lung Neoplasms - classification</topic><topic>Lung Neoplasms - mortality</topic><topic>Lung Neoplasms - pathology</topic><topic>Male</topic><topic>Malignancy</topic><topic>Middle Aged</topic><topic>Necrosis</topic><topic>Neoplasm Grading</topic><topic>Prognosis</topic><topic>Proportional Hazards Models</topic><topic>Retrospective Studies</topic><topic>smoking</topic><topic>Thorax</topic><topic>Treatment Outcome</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mäkinen, Johanna M</creatorcontrib><creatorcontrib>Laitakari, Kirsi</creatorcontrib><creatorcontrib>Johnson, Shirley</creatorcontrib><creatorcontrib>Mäkitaro, Riitta</creatorcontrib><creatorcontrib>Bloigu, Risto</creatorcontrib><creatorcontrib>Pääkkö, Paavo</creatorcontrib><creatorcontrib>Lappi‐Blanco, Elisa</creatorcontrib><creatorcontrib>Kaarteenaho, Riitta</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Histopathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mäkinen, Johanna M</au><au>Laitakari, Kirsi</au><au>Johnson, Shirley</au><au>Mäkitaro, Riitta</au><au>Bloigu, Risto</au><au>Pääkkö, Paavo</au><au>Lappi‐Blanco, Elisa</au><au>Kaarteenaho, Riitta</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Histological features of malignancy correlate with growth patterns and patient outcome in lung adenocarcinoma</atitle><jtitle>Histopathology</jtitle><addtitle>Histopathology</addtitle><date>2017-09</date><risdate>2017</risdate><volume>71</volume><issue>3</issue><spage>425</spage><epage>436</epage><pages>425-436</pages><issn>0309-0167</issn><eissn>1365-2559</eissn><abstract>Aims
Until the launch of the International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society adenocarcinoma classification in 2011, there were no uniform histological grading criteria for pulmonary adenocarcinomas. The current classification highlights the prognostic importance of the various histological growth patterns observed in these morphologically heterogeneous neoplasias. In this study, we aimed to evaluate the classic histological parameters of malignancy in correlation with the growth patterns and patient outcomes in a series of 112 surgically operated stage I–IV lung adenocarcinomas.
Methods and results
Architectural growth pattern analysis was performed according to the current adenocarcinoma classification. Histological features including, for example, nuclear atypia, mitotic activity, tumour necrosis, and different patterns of invasion were assessed and correlated statistically with the architecture and the clinical data. A solid predominant histology was associated with increased levels of atypia (P = 0.027), mitotic activity (P < 0.001), necrosis (P < 0.001), and lymphovascular invasion (P = 0.001), and a non‐predominant solid pattern was associated with intra‐alveolar tumour spread (P = 0.004). The presence of a non‐predominant lepidic tumour component showed inverse correlations with atypia (P = 0.002), mitotic rate (P = 0.009), and tumour necrosis (P < 0.001). Tumour size (P < 0.001), mitotic activity (P = 0.019), tumour necrosis (P = 0.002), lymphovascular invasion (P = 0.001) and visceral pleural involvement (P = 0.001) were all associated with reduced disease‐specific survival.
Conclusions
The classic histological features of malignancy correlate with tumour architecture and patient outcome, confirming the prognostic value of the growth pattern analysis and questioning the need for a parallel grading system in pulmonary adenocarcinoma.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>28401582</pmid><doi>10.1111/his.13236</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0001-6129-7272</orcidid></addata></record> |
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| subjects | Adenocarcinoma Adenocarcinoma - classification Adenocarcinoma - mortality Adenocarcinoma - pathology Adenocarcinoma of Lung Adult Aged Alveoli Classification Disease-Free Survival Female Gangrene Growth patterns Histology Humans Kaplan-Meier Estimate lung adenocarcinoma Lung cancer Lung Neoplasms - classification Lung Neoplasms - mortality Lung Neoplasms - pathology Male Malignancy Middle Aged Necrosis Neoplasm Grading Prognosis Proportional Hazards Models Retrospective Studies smoking Thorax Treatment Outcome Tumors |
| title | Histological features of malignancy correlate with growth patterns and patient outcome in lung adenocarcinoma |
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