Apparent Diffusion Coefficient (ADC) of the vitreous humor and Susceptibility Weighted Imaging (SWI) of the retina in abused children with retinal hemorrhages
Abstract This study speculated that the apparent diffusion coefficient (ADC) of the vitreous humor might be altered in the setting of abusive head trauma (AHT) with retinal hemorrhages (RH). Fourty-four subjects were analyzed ( n = 20 AHT cases; n = 24 controls). There was no statistically significa...
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| Veröffentlicht in: | Clinical imaging 2017-07, Vol.44, p.38-41 |
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| creator | Hwang, Misun Shin, Samuel S Thimm, Matthew A Ghodadra, Anish Sylvester, Christin L Nischal, Ken Panigrahy, Ashok Zuccoli, Giulio |
| description | Abstract This study speculated that the apparent diffusion coefficient (ADC) of the vitreous humor might be altered in the setting of abusive head trauma (AHT) with retinal hemorrhages (RH). Fourty-four subjects were analyzed ( n = 20 AHT cases; n = 24 controls). There was no statistically significant difference in normalized ADC values between the cases and controls (− 0.14 and − 0.08 respectively, p = 0.46), but analysis of RH by susceptibility weighted imaging (SWI) compared to dilated funduscopic exam demonstrated statistically significant correlation ( p = 0.003 and 0.012). Our results suggest that SWI serves as a more sensitive diagnostic tool for detection of ocular injury in AHT than ADC. |
| doi_str_mv | 10.1016/j.clinimag.2017.03.017 |
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Fourty-four subjects were analyzed ( n = 20 AHT cases; n = 24 controls). There was no statistically significant difference in normalized ADC values between the cases and controls (− 0.14 and − 0.08 respectively, p = 0.46), but analysis of RH by susceptibility weighted imaging (SWI) compared to dilated funduscopic exam demonstrated statistically significant correlation ( p = 0.003 and 0.012). Our results suggest that SWI serves as a more sensitive diagnostic tool for detection of ocular injury in AHT than ADC.</description><identifier>ISSN: 0899-7071</identifier><identifier>EISSN: 1873-4499</identifier><identifier>DOI: 10.1016/j.clinimag.2017.03.017</identifier><identifier>PMID: 28399448</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Abusive head trauma ; Apparent diffusion coefficient ; Child Abuse ; Children ; Collagen ; Craniocerebral Trauma - complications ; Craniocerebral Trauma - diagnostic imaging ; Craniocerebral Trauma - pathology ; Cytokines ; Diagnostic software ; Diagnostic systems ; Diffusion coefficient ; Female ; Head injuries ; Hemorrhage ; Humans ; Infant ; Magnetic Resonance Spectroscopy - methods ; Male ; Mechanical properties ; Pediatrics ; Radiology ; Retina ; Retina - diagnostic imaging ; Retina - pathology ; Retinal Hemorrhage - diagnostic imaging ; Retinal Hemorrhage - etiology ; Retinal Hemorrhage - pathology ; Retrospective Studies ; Statistical analysis ; Statistical significance ; Susceptibility weighted imaging ; Trauma ; Vitreous ; Vitreous Body - diagnostic imaging ; Vitreous Body - pathology ; Vitreous humor</subject><ispartof>Clinical imaging, 2017-07, Vol.44, p.38-41</ispartof><rights>Elsevier Inc.</rights><rights>2017 Elsevier Inc.</rights><rights>Copyright © 2017 Elsevier Inc. All rights reserved.</rights><rights>Copyright Elsevier Limited 2017</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c451t-332b582f062796a86bd2866234193b0f26d281ff1c4600e0d25d86dcbafd4fdf3</citedby><cites>FETCH-LOGICAL-c451t-332b582f062796a86bd2866234193b0f26d281ff1c4600e0d25d86dcbafd4fdf3</cites><orcidid>0000-0003-4548-5577</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.clinimag.2017.03.017$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28399448$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hwang, Misun</creatorcontrib><creatorcontrib>Shin, Samuel S</creatorcontrib><creatorcontrib>Thimm, Matthew A</creatorcontrib><creatorcontrib>Ghodadra, Anish</creatorcontrib><creatorcontrib>Sylvester, Christin L</creatorcontrib><creatorcontrib>Nischal, Ken</creatorcontrib><creatorcontrib>Panigrahy, Ashok</creatorcontrib><creatorcontrib>Zuccoli, Giulio</creatorcontrib><title>Apparent Diffusion Coefficient (ADC) of the vitreous humor and Susceptibility Weighted Imaging (SWI) of the retina in abused children with retinal hemorrhages</title><title>Clinical imaging</title><addtitle>Clin Imaging</addtitle><description>Abstract This study speculated that the apparent diffusion coefficient (ADC) of the vitreous humor might be altered in the setting of abusive head trauma (AHT) with retinal hemorrhages (RH). Fourty-four subjects were analyzed ( n = 20 AHT cases; n = 24 controls). There was no statistically significant difference in normalized ADC values between the cases and controls (− 0.14 and − 0.08 respectively, p = 0.46), but analysis of RH by susceptibility weighted imaging (SWI) compared to dilated funduscopic exam demonstrated statistically significant correlation ( p = 0.003 and 0.012). Our results suggest that SWI serves as a more sensitive diagnostic tool for detection of ocular injury in AHT than ADC.</description><subject>Abusive head trauma</subject><subject>Apparent diffusion coefficient</subject><subject>Child Abuse</subject><subject>Children</subject><subject>Collagen</subject><subject>Craniocerebral Trauma - complications</subject><subject>Craniocerebral Trauma - diagnostic imaging</subject><subject>Craniocerebral Trauma - pathology</subject><subject>Cytokines</subject><subject>Diagnostic software</subject><subject>Diagnostic systems</subject><subject>Diffusion coefficient</subject><subject>Female</subject><subject>Head injuries</subject><subject>Hemorrhage</subject><subject>Humans</subject><subject>Infant</subject><subject>Magnetic Resonance Spectroscopy - methods</subject><subject>Male</subject><subject>Mechanical properties</subject><subject>Pediatrics</subject><subject>Radiology</subject><subject>Retina</subject><subject>Retina - diagnostic imaging</subject><subject>Retina - pathology</subject><subject>Retinal Hemorrhage - diagnostic imaging</subject><subject>Retinal Hemorrhage - etiology</subject><subject>Retinal Hemorrhage - pathology</subject><subject>Retrospective Studies</subject><subject>Statistical analysis</subject><subject>Statistical significance</subject><subject>Susceptibility weighted imaging</subject><subject>Trauma</subject><subject>Vitreous</subject><subject>Vitreous Body - diagnostic imaging</subject><subject>Vitreous Body - pathology</subject><subject>Vitreous humor</subject><issn>0899-7071</issn><issn>1873-4499</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFksuO0zAUhiMEYsrAK4wsseksUnyLk2wQVYdLpZFYFDRLy7GPG5c0KbYzqC_Ds-LQziDNhtWR7e8_F_8ny64IXhBMxLvdQneud3u1XVBMygVmixSeZTNSlSznvK6fZzNc1XVe4pJcZK9C2OEkrHn5MrugFatrzqtZ9nt5OCgPfUQ3ztoxuKFHqwGsddpNt_PlzeoaDRbFFtC9ix6GMaB23A8eqd6gzRg0HKJrXOfiEd2B27YRDFqnzly_RfPN3fpR7yG6XiHXI9WMIVG6dZ1J1dEvF9vzc4daSNl9q7YQXmcvrOoCvDnHy-z7p4_fVl_y26-f16vlba55QWLOGG2KilosaFkLVYnG0EoIyjipWYMtFelMrCWaC4wBG1qYShjdKGu4NZZdZvNT3oMffo4Qoty7NFjXqX4aWJKqKnHBCsET-vYJuhtGn_pOVI1LRhgrcKLEidJ-CMGDlQef3PJHSbCcHJQ7-eCgnByUmMkUkvDqnH5s9mAeZQ-WJeDDCYD0H_cOvAyTVRqM86CjNIP7f433T1L8xbTqfsARwr95ZKASy820R9MaJSnGBafsD9_Oxaw</recordid><startdate>20170701</startdate><enddate>20170701</enddate><creator>Hwang, Misun</creator><creator>Shin, Samuel S</creator><creator>Thimm, Matthew A</creator><creator>Ghodadra, Anish</creator><creator>Sylvester, Christin L</creator><creator>Nischal, Ken</creator><creator>Panigrahy, Ashok</creator><creator>Zuccoli, Giulio</creator><general>Elsevier Inc</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>M7Z</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-4548-5577</orcidid></search><sort><creationdate>20170701</creationdate><title>Apparent Diffusion Coefficient (ADC) of the vitreous humor and Susceptibility Weighted Imaging (SWI) of the retina in abused children with retinal hemorrhages</title><author>Hwang, Misun ; Shin, Samuel S ; Thimm, Matthew A ; Ghodadra, Anish ; Sylvester, Christin L ; Nischal, Ken ; Panigrahy, Ashok ; Zuccoli, Giulio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c451t-332b582f062796a86bd2866234193b0f26d281ff1c4600e0d25d86dcbafd4fdf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Abusive head trauma</topic><topic>Apparent diffusion coefficient</topic><topic>Child Abuse</topic><topic>Children</topic><topic>Collagen</topic><topic>Craniocerebral Trauma - complications</topic><topic>Craniocerebral Trauma - diagnostic imaging</topic><topic>Craniocerebral Trauma - pathology</topic><topic>Cytokines</topic><topic>Diagnostic software</topic><topic>Diagnostic systems</topic><topic>Diffusion coefficient</topic><topic>Female</topic><topic>Head injuries</topic><topic>Hemorrhage</topic><topic>Humans</topic><topic>Infant</topic><topic>Magnetic Resonance Spectroscopy - methods</topic><topic>Male</topic><topic>Mechanical properties</topic><topic>Pediatrics</topic><topic>Radiology</topic><topic>Retina</topic><topic>Retina - diagnostic imaging</topic><topic>Retina - pathology</topic><topic>Retinal Hemorrhage - diagnostic imaging</topic><topic>Retinal Hemorrhage - etiology</topic><topic>Retinal Hemorrhage - pathology</topic><topic>Retrospective Studies</topic><topic>Statistical analysis</topic><topic>Statistical significance</topic><topic>Susceptibility weighted imaging</topic><topic>Trauma</topic><topic>Vitreous</topic><topic>Vitreous Body - diagnostic imaging</topic><topic>Vitreous Body - pathology</topic><topic>Vitreous humor</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hwang, Misun</creatorcontrib><creatorcontrib>Shin, Samuel S</creatorcontrib><creatorcontrib>Thimm, Matthew A</creatorcontrib><creatorcontrib>Ghodadra, Anish</creatorcontrib><creatorcontrib>Sylvester, Christin L</creatorcontrib><creatorcontrib>Nischal, Ken</creatorcontrib><creatorcontrib>Panigrahy, Ashok</creatorcontrib><creatorcontrib>Zuccoli, Giulio</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biochemistry Abstracts 1</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical imaging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hwang, Misun</au><au>Shin, Samuel S</au><au>Thimm, Matthew A</au><au>Ghodadra, Anish</au><au>Sylvester, Christin L</au><au>Nischal, Ken</au><au>Panigrahy, Ashok</au><au>Zuccoli, Giulio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Apparent Diffusion Coefficient (ADC) of the vitreous humor and Susceptibility Weighted Imaging (SWI) of the retina in abused children with retinal hemorrhages</atitle><jtitle>Clinical imaging</jtitle><addtitle>Clin Imaging</addtitle><date>2017-07-01</date><risdate>2017</risdate><volume>44</volume><spage>38</spage><epage>41</epage><pages>38-41</pages><issn>0899-7071</issn><eissn>1873-4499</eissn><abstract>Abstract This study speculated that the apparent diffusion coefficient (ADC) of the vitreous humor might be altered in the setting of abusive head trauma (AHT) with retinal hemorrhages (RH). Fourty-four subjects were analyzed ( n = 20 AHT cases; n = 24 controls). There was no statistically significant difference in normalized ADC values between the cases and controls (− 0.14 and − 0.08 respectively, p = 0.46), but analysis of RH by susceptibility weighted imaging (SWI) compared to dilated funduscopic exam demonstrated statistically significant correlation ( p = 0.003 and 0.012). Our results suggest that SWI serves as a more sensitive diagnostic tool for detection of ocular injury in AHT than ADC.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>28399448</pmid><doi>10.1016/j.clinimag.2017.03.017</doi><tpages>4</tpages><orcidid>https://orcid.org/0000-0003-4548-5577</orcidid></addata></record> |
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| subjects | Abusive head trauma Apparent diffusion coefficient Child Abuse Children Collagen Craniocerebral Trauma - complications Craniocerebral Trauma - diagnostic imaging Craniocerebral Trauma - pathology Cytokines Diagnostic software Diagnostic systems Diffusion coefficient Female Head injuries Hemorrhage Humans Infant Magnetic Resonance Spectroscopy - methods Male Mechanical properties Pediatrics Radiology Retina Retina - diagnostic imaging Retina - pathology Retinal Hemorrhage - diagnostic imaging Retinal Hemorrhage - etiology Retinal Hemorrhage - pathology Retrospective Studies Statistical analysis Statistical significance Susceptibility weighted imaging Trauma Vitreous Vitreous Body - diagnostic imaging Vitreous Body - pathology Vitreous humor |
| title | Apparent Diffusion Coefficient (ADC) of the vitreous humor and Susceptibility Weighted Imaging (SWI) of the retina in abused children with retinal hemorrhages |
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