Treadmill Walking Combined With Anodal Transcranial Direct Current Stimulation in Parkinson Disease: A Pilot Study of Kinematic and Neurophysiological Effects
We tested the hypothesis that combining treadmill walking with transcranial direct current stimulation (tDCS) enhances the gait improvements associated with treadmill walking in Parkinson disease. We explored the effects of these combined methodologies on corticospinal parameters. Eighteen participa...
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| Veröffentlicht in: | American journal of physical medicine & rehabilitation 2017-11, Vol.96 (11), p.801-808 |
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| container_title | American journal of physical medicine & rehabilitation |
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| creator | Fernández-Lago, Helena Bello, Olalla Mora-Cerdá, Francina Montero-Cámara, Jorge Fernández-Del-Olmo, Miguel Ángel |
| description | We tested the hypothesis that combining treadmill walking with transcranial direct current stimulation (tDCS) enhances the gait improvements associated with treadmill walking in Parkinson disease. We explored the effects of these combined methodologies on corticospinal parameters.
Eighteen participants with Parkinson disease were evaluated under the following three conditions: treadmill walking alone (treadmill), treadmill walking combined with anodal tDCS (AtDCS+treadmill) delivered over the motor cortex, and treadmill walking combined with sham stimulation (StDCS+treadmill). Overground walking performance, soleus H-reflex, reciprocal Ia inhibition from the tibialis anterior to the soleus muscle, intracortical facilitation, and short intracortical inhibition of the tibialis anterior muscle, were measured before and after each treadmill condition. The soleus H-reflex and walking performance on the treadmill were also evaluated.
All treadmill conditions improved walking performance and modulated spinal and corticospinal parameters in a similar way. However, AtDCS+treadmill lead to a different modulation of reciprocal Ia inhibition in comparison with the other treadmill conditions.
A single session combining treadmill walking and anodal tDCS delivered over the motor cortex resulted in a specific modulation of the reciprocal Ia inhibition from the tibialis anterior to the soleus muscle. However, this acute effect did not result in improvements of gait parameters associated with treadmill walking in Parkinson disease. |
| doi_str_mv | 10.1097/PHM.0000000000000751 |
| format | Article |
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Eighteen participants with Parkinson disease were evaluated under the following three conditions: treadmill walking alone (treadmill), treadmill walking combined with anodal tDCS (AtDCS+treadmill) delivered over the motor cortex, and treadmill walking combined with sham stimulation (StDCS+treadmill). Overground walking performance, soleus H-reflex, reciprocal Ia inhibition from the tibialis anterior to the soleus muscle, intracortical facilitation, and short intracortical inhibition of the tibialis anterior muscle, were measured before and after each treadmill condition. The soleus H-reflex and walking performance on the treadmill were also evaluated.
All treadmill conditions improved walking performance and modulated spinal and corticospinal parameters in a similar way. However, AtDCS+treadmill lead to a different modulation of reciprocal Ia inhibition in comparison with the other treadmill conditions.
A single session combining treadmill walking and anodal tDCS delivered over the motor cortex resulted in a specific modulation of the reciprocal Ia inhibition from the tibialis anterior to the soleus muscle. However, this acute effect did not result in improvements of gait parameters associated with treadmill walking in Parkinson disease.</description><identifier>ISSN: 0894-9115</identifier><identifier>EISSN: 1537-7385</identifier><identifier>DOI: 10.1097/PHM.0000000000000751</identifier><identifier>PMID: 28398968</identifier><language>eng</language><publisher>United States</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Biomechanical Phenomena - physiology ; Combined Modality Therapy ; Evoked Potentials, Motor - physiology ; Exercise Test - methods ; Exercise Therapy - methods ; Female ; H-Reflex - physiology ; Humans ; Male ; Middle Aged ; Motor Cortex - physiopathology ; Muscle, Skeletal - physiopathology ; Parkinson Disease - physiopathology ; Parkinson Disease - rehabilitation ; Pilot Projects ; Transcranial Direct Current Stimulation - methods ; Treatment Outcome ; Walking - physiology</subject><ispartof>American journal of physical medicine & rehabilitation, 2017-11, Vol.96 (11), p.801-808</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c256t-3734bac517c4e07183a511517ef59e5459d7c43d45f32623a61f7f0804c1ebf63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28398968$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fernández-Lago, Helena</creatorcontrib><creatorcontrib>Bello, Olalla</creatorcontrib><creatorcontrib>Mora-Cerdá, Francina</creatorcontrib><creatorcontrib>Montero-Cámara, Jorge</creatorcontrib><creatorcontrib>Fernández-Del-Olmo, Miguel Ángel</creatorcontrib><title>Treadmill Walking Combined With Anodal Transcranial Direct Current Stimulation in Parkinson Disease: A Pilot Study of Kinematic and Neurophysiological Effects</title><title>American journal of physical medicine & rehabilitation</title><addtitle>Am J Phys Med Rehabil</addtitle><description>We tested the hypothesis that combining treadmill walking with transcranial direct current stimulation (tDCS) enhances the gait improvements associated with treadmill walking in Parkinson disease. We explored the effects of these combined methodologies on corticospinal parameters.
Eighteen participants with Parkinson disease were evaluated under the following three conditions: treadmill walking alone (treadmill), treadmill walking combined with anodal tDCS (AtDCS+treadmill) delivered over the motor cortex, and treadmill walking combined with sham stimulation (StDCS+treadmill). Overground walking performance, soleus H-reflex, reciprocal Ia inhibition from the tibialis anterior to the soleus muscle, intracortical facilitation, and short intracortical inhibition of the tibialis anterior muscle, were measured before and after each treadmill condition. The soleus H-reflex and walking performance on the treadmill were also evaluated.
All treadmill conditions improved walking performance and modulated spinal and corticospinal parameters in a similar way. However, AtDCS+treadmill lead to a different modulation of reciprocal Ia inhibition in comparison with the other treadmill conditions.
A single session combining treadmill walking and anodal tDCS delivered over the motor cortex resulted in a specific modulation of the reciprocal Ia inhibition from the tibialis anterior to the soleus muscle. However, this acute effect did not result in improvements of gait parameters associated with treadmill walking in Parkinson disease.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biomechanical Phenomena - physiology</subject><subject>Combined Modality Therapy</subject><subject>Evoked Potentials, Motor - physiology</subject><subject>Exercise Test - methods</subject><subject>Exercise Therapy - methods</subject><subject>Female</subject><subject>H-Reflex - physiology</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Motor Cortex - physiopathology</subject><subject>Muscle, Skeletal - physiopathology</subject><subject>Parkinson Disease - physiopathology</subject><subject>Parkinson Disease - rehabilitation</subject><subject>Pilot Projects</subject><subject>Transcranial Direct Current Stimulation - methods</subject><subject>Treatment Outcome</subject><subject>Walking - physiology</subject><issn>0894-9115</issn><issn>1537-7385</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdUU1P4zAQtRBoKbD_ACEfuQTsOI4dblULC4JdKm1XHCPXGYPBsYudHPpn9rdixIcQc5jRaN6bp5mH0CElJ5Q04nRx-fuEfA3B6RaaUM5EIZjk22hCZFMVDaV8F-2l9JgxvGHiB9otJWtkU8sJ-r-MoLreOofvlHuy_h7PQr-yHjp8Z4cHPPWhUw4vo_JJ52RzM7cR9IBnY4zgB_x3sP3o1GCDx9bjhYp5T8rN3CZQCc7wFC-sC6_IsdvgYPB1FugzQ2PlO_wHxhjWD5tkgwv3VmeJc2OyRDpAO0a5BD_f6z76d3G-nF0WN7e_rmbTm0KXvB4KJli1UppToSsggkqmeD6bCjC8AV7xpssT1lXcsLIumaqpEYZIUmkKK1OzfXT8tncdw_MIaWh7mzQ4pzyEMbVUSkF4mT-YodUbVMeQUgTTrqPtVdy0lLSvzrTZmfa7M5l29K4wrnroPkkfVrAXKIKLDA</recordid><startdate>201711</startdate><enddate>201711</enddate><creator>Fernández-Lago, Helena</creator><creator>Bello, Olalla</creator><creator>Mora-Cerdá, Francina</creator><creator>Montero-Cámara, Jorge</creator><creator>Fernández-Del-Olmo, Miguel Ángel</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201711</creationdate><title>Treadmill Walking Combined With Anodal Transcranial Direct Current Stimulation in Parkinson Disease: A Pilot Study of Kinematic and Neurophysiological Effects</title><author>Fernández-Lago, Helena ; Bello, Olalla ; Mora-Cerdá, Francina ; Montero-Cámara, Jorge ; Fernández-Del-Olmo, Miguel Ángel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c256t-3734bac517c4e07183a511517ef59e5459d7c43d45f32623a61f7f0804c1ebf63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biomechanical Phenomena - physiology</topic><topic>Combined Modality Therapy</topic><topic>Evoked Potentials, Motor - physiology</topic><topic>Exercise Test - methods</topic><topic>Exercise Therapy - methods</topic><topic>Female</topic><topic>H-Reflex - physiology</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Motor Cortex - physiopathology</topic><topic>Muscle, Skeletal - physiopathology</topic><topic>Parkinson Disease - physiopathology</topic><topic>Parkinson Disease - rehabilitation</topic><topic>Pilot Projects</topic><topic>Transcranial Direct Current Stimulation - methods</topic><topic>Treatment Outcome</topic><topic>Walking - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fernández-Lago, Helena</creatorcontrib><creatorcontrib>Bello, Olalla</creatorcontrib><creatorcontrib>Mora-Cerdá, Francina</creatorcontrib><creatorcontrib>Montero-Cámara, Jorge</creatorcontrib><creatorcontrib>Fernández-Del-Olmo, Miguel Ángel</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of physical medicine & rehabilitation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fernández-Lago, Helena</au><au>Bello, Olalla</au><au>Mora-Cerdá, Francina</au><au>Montero-Cámara, Jorge</au><au>Fernández-Del-Olmo, Miguel Ángel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Treadmill Walking Combined With Anodal Transcranial Direct Current Stimulation in Parkinson Disease: A Pilot Study of Kinematic and Neurophysiological Effects</atitle><jtitle>American journal of physical medicine & rehabilitation</jtitle><addtitle>Am J Phys Med Rehabil</addtitle><date>2017-11</date><risdate>2017</risdate><volume>96</volume><issue>11</issue><spage>801</spage><epage>808</epage><pages>801-808</pages><issn>0894-9115</issn><eissn>1537-7385</eissn><abstract>We tested the hypothesis that combining treadmill walking with transcranial direct current stimulation (tDCS) enhances the gait improvements associated with treadmill walking in Parkinson disease. We explored the effects of these combined methodologies on corticospinal parameters.
Eighteen participants with Parkinson disease were evaluated under the following three conditions: treadmill walking alone (treadmill), treadmill walking combined with anodal tDCS (AtDCS+treadmill) delivered over the motor cortex, and treadmill walking combined with sham stimulation (StDCS+treadmill). Overground walking performance, soleus H-reflex, reciprocal Ia inhibition from the tibialis anterior to the soleus muscle, intracortical facilitation, and short intracortical inhibition of the tibialis anterior muscle, were measured before and after each treadmill condition. The soleus H-reflex and walking performance on the treadmill were also evaluated.
All treadmill conditions improved walking performance and modulated spinal and corticospinal parameters in a similar way. However, AtDCS+treadmill lead to a different modulation of reciprocal Ia inhibition in comparison with the other treadmill conditions.
A single session combining treadmill walking and anodal tDCS delivered over the motor cortex resulted in a specific modulation of the reciprocal Ia inhibition from the tibialis anterior to the soleus muscle. However, this acute effect did not result in improvements of gait parameters associated with treadmill walking in Parkinson disease.</abstract><cop>United States</cop><pmid>28398968</pmid><doi>10.1097/PHM.0000000000000751</doi><tpages>8</tpages></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Biomechanical Phenomena - physiology Combined Modality Therapy Evoked Potentials, Motor - physiology Exercise Test - methods Exercise Therapy - methods Female H-Reflex - physiology Humans Male Middle Aged Motor Cortex - physiopathology Muscle, Skeletal - physiopathology Parkinson Disease - physiopathology Parkinson Disease - rehabilitation Pilot Projects Transcranial Direct Current Stimulation - methods Treatment Outcome Walking - physiology |
| title | Treadmill Walking Combined With Anodal Transcranial Direct Current Stimulation in Parkinson Disease: A Pilot Study of Kinematic and Neurophysiological Effects |
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