Antifungal mechanism of [RuIII(NH3)4catechol]+ complex on fluconazole-resistant Candida tropicalis

Abstract Candidiasis, a major opportunistic mycosis caused by Candida sp., may comprise life-threatening systemic infections. The incidence of non-albicans species is rising, particularly in South America and they are frequently drug resistant, causing unresponsive cases. Thus, novel antimycotic age...

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Veröffentlicht in:	FEMS microbiology letters 2017-05, Vol.364 (9)
Hauptverfasser:	Gomes-Junior, Rafael Araújo, da Silva, Roberto Santana, de Lima, Renata Galvão, Vannier-Santos, Marcos A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Ammonia Animals Antifungal activity Antifungal agents Antifungal Agents - chemistry Antifungal Agents - pharmacology Candida tropicalis Candida tropicalis - drug effects Candida tropicalis - growth & development Candida tropicalis - ultrastructure Candidiasis Catechol Cell Death Cell surface Cell Wall - drug effects Cell walls Chitin Coordination Complexes - pharmacology Cytotoxicity Drug resistance Drug Resistance, Fungal Electron microscopy Fluconazole Fluconazole - pharmacology Fungal infections Fungicides Humans Inhibitory Concentration 50 Labeling Melanin Mice Microbial Sensitivity Tests Microbial Viability - drug effects Microbiology Microscopy Mycosis Pseudohyphae Reactive oxygen species Reactive Oxygen Species - metabolism Ruthenium Scanning electron microscopy Spleen - cytology Spleen - drug effects Spleen - microbiology Splenocytes Toxicity Transmission electron microscopy Yeast Yeasts
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