The Hepatic Protection Effects of Hepassocin in Hyperglycemic Crisis

Abstract Context: High glucose generates reactive oxygen species (ROS) and contributes to glucotoxicity in hepatocytes, and hyperglycemia causes structural and functional damage to the liver. However, only a mild hepatic dysfunction was observed in subjects with hyperglycemic crisis, implying a fact...

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Veröffentlicht in:	The journal of clinical endocrinology and metabolism 2017-07, Vol.102 (7), p.2407-2415
Hauptverfasser:	Ou, Horng-Yih, Wu, Hung-Tsung, Lin, Ching-Han, Du, Ye-Fong, Hu, Che-Yuan, Hung, Hao-Chang, Wu, Pansee, Li, Hung-Yuan, Wang, Shu-Huei, Chang, Chih-Jen
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetic acid Adult Analysis of Variance Animals Blotting, Western Cells, Cultured Crises Disease Models, Animal Ethyl acetate Extracellular signal-regulated kinase Glucose Heat shock proteins Hep G2 Cells - metabolism Hepatocytes Humans Hyperglycemia Hyperglycemia - diagnosis Hyperglycemia - drug therapy Hypoglycemic Agents - administration & dosage Liver Liver Failure - prevention & control Male Metabolism Mice Mice, Inbred C57BL Mice, Obese Middle Aged Neoplasm Proteins - metabolism Proteins Random Allocation Reactive oxygen species Reactive Oxygen Species - metabolism Real-Time Polymerase Chain Reaction - methods RNA, Small Interfering - metabolism Rodents Sampling Studies Secretion Streptozocin Streptozocin - pharmacology Stress proteins Structure-function relationships Superoxide dismutase Transcription Transfection
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