Thyroid Hormone Therapy for Older Adults with Subclinical Hypothyroidism

A double-blind, randomized, placebo-controlled, parallel-group trial aimed to determine whether levothyroxine provided clinical benefits in older persons with subclinical hypothyroidism. No apparent benefits were observed. Subclinical hypothyroidism is defined as an elevated serum thyrotropin level...

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Veröffentlicht in:	The New England journal of medicine 2017-06, Vol.376 (26), p.2534-2544
Hauptverfasser:	Stott, David J, Rodondi, Nicolas, Kearney, Patricia M, Ford, Ian, Westendorp, Rudi G.J, Mooijaart, Simon P, Sattar, Naveed, Aubert, Carole E, Aujesky, Drahomir, Bauer, Douglas C, Baumgartner, Christine, Blum, Manuel R, Browne, John P, Byrne, Stephen, Collet, Tinh-Hai, Dekkers, Olaf M, den Elzen, Wendy P.J, Du Puy, Robert S, Ellis, Graham, Feller, Martin, Floriani, Carmen, Hendry, Kirsty, Hurley, Caroline, Jukema, J. Wouter, Kean, Sharon, Kelly, Maria, Krebs, Danielle, Langhorne, Peter, McCarthy, Gemma, McCarthy, Vera, McConnachie, Alex, McDade, Mairi, Messow, Martina, O’Flynn, Annemarie, O’Riordan, David, Poortvliet, Rosalinde K.E, Quinn, Terence J, Russell, Audrey, Sinnott, Carol, Smit, Jan W.A, Van Dorland, H. Anette, Walsh, Kieran A, Walsh, Elaine K, Watt, Torquil, Wilson, Robbie, Gussekloo, Jacobijn
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Aged Aged, 80 and over Body weight Clinical trials Coronary artery disease Double-Blind Method Drug dosages Drug therapy Endocrine therapy Endocrinology Epidemiology Fatigue - etiology Female Heart diseases Hormone replacement therapy Humans Hypothyroidism Hypothyroidism - complications Hypothyroidism - drug therapy Intention to Treat Analysis Male Older people Quality of Life Thyroid Thyroid gland Thyroid-stimulating hormone Thyrotropin - blood Thyroxine Thyroxine - administration & dosage Thyroxine - adverse effects Thyroxine - blood Treatment Failure
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