Grandmaternal smoke exposure reduces female fertility in a murine model, with great-grandmaternal smoke exposure unlikely to have an effect

Abstract STUDY QUESTION What effect does multigenerational (F2) and transgenerational (F3) cigarette smoke exposure have on female fertility in mice? SUMMARY ANSWER Cigarette smoking has a multigenerational effect on female fertility. WHAT IS KNOWN ALREADY It has been well established that cigarette...

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Veröffentlicht in:	Human reproduction (Oxford) 2017-06, Vol.32 (6), p.1270-1281
Hauptverfasser:	Camlin, N.J., Jarnicki, A.G., Vanders, R.L., Walters, K.A., Hansbro, P.M., McLaughlin, E.A., Holt, J.E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Biomarkers - blood Biomarkers - metabolism Cigarette Smoking - adverse effects Ectogenesis Female Fetal Development - drug effects Fluorescent Antibody Technique Immunohistochemistry Infertility, Female - etiology Infertility, Female - metabolism Infertility, Female - pathology Infertility, Female - physiopathology Lactation Maternal Exposure - adverse effects Mice, Inbred C57BL Oocytes - metabolism Oocytes - pathology Oogenesis Ovary - metabolism Ovary - pathology Pregnancy Prenatal Exposure Delayed Effects Severity of Illness Index Time-to-Pregnancy
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