Renal cell cancer risk and occupational exposure to trichloroethylene: Results of a consecutive case-control study in Arnsberg, Germany
Background German studies of high exposure prevalence have been debated on the renal carcinogenicity of trichloroethylene (TRI). Methods A consecutive hospital‐based case‐control study with 134 renal cell cancer (RCC) cases and 401 controls was conducted to reevaluate the risk of TRI in this region...
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| Veröffentlicht in: | American journal of industrial medicine 2003-03, Vol.43 (3), p.274-285 |
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| container_title | American journal of industrial medicine |
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| creator | Brüning, Thomas Pesch, Beate Wiesenhütter, Bernd Rabstein, Sylvia Lammert, Marga Baumüller, Axel Bolt, Hermann M. |
| description | Background
German studies of high exposure prevalence have been debated on the renal carcinogenicity of trichloroethylene (TRI).
Methods
A consecutive hospital‐based case‐control study with 134 renal cell cancer (RCC) cases and 401 controls was conducted to reevaluate the risk of TRI in this region which were estimated in a previous study. Exposure was self‐assessed to compare these studies. Additionally, the job history was analyzed, using expert‐based exposure information.
Results
The logistic regression results, adjusted for age, gender, and smoking, confirmed a TRI‐related RCC risk in this region. Using the database CAREX for a comparison of industries with and without TRI exposure, a significant excess risk was estimated for the longest held job in TRI‐exposing industries (odds ratio (OR) 1.80, 95% confidence interval (CI) 1.01–3.20). Any exposure in “metal degreasing” was a RCC risk factor (OR 5.57, 95% CI 2.33–13.32). Self‐reported narcotic symptoms, indicative of peak exposures, were associated with an excess risk (OR 3.71, 95% CI 1.80–7.54).
Conclusions
The study supports the human nephrocarcinogenicity of trichloroethylene. Am. J. Ind. Med. 43:274–285, 2003. © 2003 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/ajim.10185 |
| format | Article |
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German studies of high exposure prevalence have been debated on the renal carcinogenicity of trichloroethylene (TRI).
Methods
A consecutive hospital‐based case‐control study with 134 renal cell cancer (RCC) cases and 401 controls was conducted to reevaluate the risk of TRI in this region which were estimated in a previous study. Exposure was self‐assessed to compare these studies. Additionally, the job history was analyzed, using expert‐based exposure information.
Results
The logistic regression results, adjusted for age, gender, and smoking, confirmed a TRI‐related RCC risk in this region. Using the database CAREX for a comparison of industries with and without TRI exposure, a significant excess risk was estimated for the longest held job in TRI‐exposing industries (odds ratio (OR) 1.80, 95% confidence interval (CI) 1.01–3.20). Any exposure in “metal degreasing” was a RCC risk factor (OR 5.57, 95% CI 2.33–13.32). Self‐reported narcotic symptoms, indicative of peak exposures, were associated with an excess risk (OR 3.71, 95% CI 1.80–7.54).
Conclusions
The study supports the human nephrocarcinogenicity of trichloroethylene. Am. J. Ind. Med. 43:274–285, 2003. © 2003 Wiley‐Liss, Inc.</description><identifier>ISSN: 0271-3586</identifier><identifier>EISSN: 1097-0274</identifier><identifier>DOI: 10.1002/ajim.10185</identifier><identifier>PMID: 12594774</identifier><identifier>CODEN: AJIMD8</identifier><language>eng</language><publisher>New York: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Aged ; Biological and medical sciences ; Carcinoma, Renal Cell - chemically induced ; Carcinoma, Renal Cell - epidemiology ; Case-Control Studies ; case-control study ; Female ; Germany - epidemiology ; Humans ; Interviews as Topic ; job-exposure matrix ; Kidney Neoplasms - chemically induced ; Kidney Neoplasms - epidemiology ; Kidneys ; Logistic Models ; Male ; Medical sciences ; Metallurgy ; nephrocarcinogenicity ; Nephrology. Urinary tract diseases ; occupational exposure ; Occupational Exposure - adverse effects ; Occupations - statistics & numerical data ; renal cell carcinoma ; Risk Factors ; Solvents - adverse effects ; trichloroethene ; trichloroethylene ; Trichloroethylene - adverse effects ; Tumors of the urinary system</subject><ispartof>American journal of industrial medicine, 2003-03, Vol.43 (3), p.274-285</ispartof><rights>Copyright © 2003 Wiley‐Liss, Inc.</rights><rights>2003 INIST-CNRS</rights><rights>Copyright 2003 Wiley-Liss, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4605-17eddb143a5f32acaaf21bdbc1fe916d432d9b1bf65f67a4637b360ef4721caf3</citedby><cites>FETCH-LOGICAL-c4605-17eddb143a5f32acaaf21bdbc1fe916d432d9b1bf65f67a4637b360ef4721caf3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fajim.10185$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fajim.10185$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1416,27915,27916,45565,45566</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14576500$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12594774$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Brüning, Thomas</creatorcontrib><creatorcontrib>Pesch, Beate</creatorcontrib><creatorcontrib>Wiesenhütter, Bernd</creatorcontrib><creatorcontrib>Rabstein, Sylvia</creatorcontrib><creatorcontrib>Lammert, Marga</creatorcontrib><creatorcontrib>Baumüller, Axel</creatorcontrib><creatorcontrib>Bolt, Hermann M.</creatorcontrib><title>Renal cell cancer risk and occupational exposure to trichloroethylene: Results of a consecutive case-control study in Arnsberg, Germany</title><title>American journal of industrial medicine</title><addtitle>Am. J. Ind. Med</addtitle><description>Background
German studies of high exposure prevalence have been debated on the renal carcinogenicity of trichloroethylene (TRI).
Methods
A consecutive hospital‐based case‐control study with 134 renal cell cancer (RCC) cases and 401 controls was conducted to reevaluate the risk of TRI in this region which were estimated in a previous study. Exposure was self‐assessed to compare these studies. Additionally, the job history was analyzed, using expert‐based exposure information.
Results
The logistic regression results, adjusted for age, gender, and smoking, confirmed a TRI‐related RCC risk in this region. Using the database CAREX for a comparison of industries with and without TRI exposure, a significant excess risk was estimated for the longest held job in TRI‐exposing industries (odds ratio (OR) 1.80, 95% confidence interval (CI) 1.01–3.20). Any exposure in “metal degreasing” was a RCC risk factor (OR 5.57, 95% CI 2.33–13.32). Self‐reported narcotic symptoms, indicative of peak exposures, were associated with an excess risk (OR 3.71, 95% CI 1.80–7.54).
Conclusions
The study supports the human nephrocarcinogenicity of trichloroethylene. Am. J. Ind. Med. 43:274–285, 2003. © 2003 Wiley‐Liss, Inc.</description><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Carcinoma, Renal Cell - chemically induced</subject><subject>Carcinoma, Renal Cell - epidemiology</subject><subject>Case-Control Studies</subject><subject>case-control study</subject><subject>Female</subject><subject>Germany - epidemiology</subject><subject>Humans</subject><subject>Interviews as Topic</subject><subject>job-exposure matrix</subject><subject>Kidney Neoplasms - chemically induced</subject><subject>Kidney Neoplasms - epidemiology</subject><subject>Kidneys</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Metallurgy</subject><subject>nephrocarcinogenicity</subject><subject>Nephrology. Urinary tract diseases</subject><subject>occupational exposure</subject><subject>Occupational Exposure - adverse effects</subject><subject>Occupations - statistics & numerical data</subject><subject>renal cell carcinoma</subject><subject>Risk Factors</subject><subject>Solvents - adverse effects</subject><subject>trichloroethene</subject><subject>trichloroethylene</subject><subject>Trichloroethylene - adverse effects</subject><subject>Tumors of the urinary system</subject><issn>0271-3586</issn><issn>1097-0274</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1v1DAQhi0Eokvhwg9AvsABEfAk_tj0tqpgKZSvCgTiYjnOmLpN4sVOoPkF_G287EJvXGZG1jPvyA8h94E9BcbKZ-bC93mCpbhBFsBqVbBS8ZtkkRsUlVjKA3InpQvGALjkt8kBlKLmSvEF-XWGg-moxS4XM1iMNPp0Sc3Q0mDttDGjD1sCrzYhTRHpGOgYvT3vQgw4ns8dDnhEzzBN3ZhocNRQG4aEdhr9D8yhCYv8MMbQ0TRO7Uz9QFdxSA3Gb0_oGmNvhvkuueVMl_Devh-STy-efzx-WZy-W58cr04LyyUTBShs2wZ4ZYSrSmONcSU0bWPBYQ2y5VXZ1g00TgonleGyUk0lGTquSrDGVYfk0S53E8P3CdOoe5-2vzcDhilpWC5lDQIy-HgH2hhSiuj0JvrexFkD01vteqtd_9Ge4Qf71Knpsb1G954z8HAPmGRN52JW7dM1x4WSgrHMwY776Tuc_3NSr16dvPl7vNjt-DTi1b8dEy-1VJUS-vPbtX6t5Psv7MNXLarfZEGslQ</recordid><startdate>200303</startdate><enddate>200303</enddate><creator>Brüning, Thomas</creator><creator>Pesch, Beate</creator><creator>Wiesenhütter, Bernd</creator><creator>Rabstein, Sylvia</creator><creator>Lammert, Marga</creator><creator>Baumüller, Axel</creator><creator>Bolt, Hermann M.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley-Liss</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T2</scope><scope>7U1</scope><scope>7U2</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>200303</creationdate><title>Renal cell cancer risk and occupational exposure to trichloroethylene: Results of a consecutive case-control study in Arnsberg, Germany</title><author>Brüning, Thomas ; Pesch, Beate ; Wiesenhütter, Bernd ; Rabstein, Sylvia ; Lammert, Marga ; Baumüller, Axel ; Bolt, Hermann M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4605-17eddb143a5f32acaaf21bdbc1fe916d432d9b1bf65f67a4637b360ef4721caf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Carcinoma, Renal Cell - chemically induced</topic><topic>Carcinoma, Renal Cell - epidemiology</topic><topic>Case-Control Studies</topic><topic>case-control study</topic><topic>Female</topic><topic>Germany - epidemiology</topic><topic>Humans</topic><topic>Interviews as Topic</topic><topic>job-exposure matrix</topic><topic>Kidney Neoplasms - chemically induced</topic><topic>Kidney Neoplasms - epidemiology</topic><topic>Kidneys</topic><topic>Logistic Models</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Metallurgy</topic><topic>nephrocarcinogenicity</topic><topic>Nephrology. Urinary tract diseases</topic><topic>occupational exposure</topic><topic>Occupational Exposure - adverse effects</topic><topic>Occupations - statistics & numerical data</topic><topic>renal cell carcinoma</topic><topic>Risk Factors</topic><topic>Solvents - adverse effects</topic><topic>trichloroethene</topic><topic>trichloroethylene</topic><topic>Trichloroethylene - adverse effects</topic><topic>Tumors of the urinary system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Brüning, Thomas</creatorcontrib><creatorcontrib>Pesch, Beate</creatorcontrib><creatorcontrib>Wiesenhütter, Bernd</creatorcontrib><creatorcontrib>Rabstein, Sylvia</creatorcontrib><creatorcontrib>Lammert, Marga</creatorcontrib><creatorcontrib>Baumüller, Axel</creatorcontrib><creatorcontrib>Bolt, Hermann M.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Risk Abstracts</collection><collection>Safety Science and Risk</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>American journal of industrial medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Brüning, Thomas</au><au>Pesch, Beate</au><au>Wiesenhütter, Bernd</au><au>Rabstein, Sylvia</au><au>Lammert, Marga</au><au>Baumüller, Axel</au><au>Bolt, Hermann M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Renal cell cancer risk and occupational exposure to trichloroethylene: Results of a consecutive case-control study in Arnsberg, Germany</atitle><jtitle>American journal of industrial medicine</jtitle><addtitle>Am. J. Ind. Med</addtitle><date>2003-03</date><risdate>2003</risdate><volume>43</volume><issue>3</issue><spage>274</spage><epage>285</epage><pages>274-285</pages><issn>0271-3586</issn><eissn>1097-0274</eissn><coden>AJIMD8</coden><abstract>Background
German studies of high exposure prevalence have been debated on the renal carcinogenicity of trichloroethylene (TRI).
Methods
A consecutive hospital‐based case‐control study with 134 renal cell cancer (RCC) cases and 401 controls was conducted to reevaluate the risk of TRI in this region which were estimated in a previous study. Exposure was self‐assessed to compare these studies. Additionally, the job history was analyzed, using expert‐based exposure information.
Results
The logistic regression results, adjusted for age, gender, and smoking, confirmed a TRI‐related RCC risk in this region. Using the database CAREX for a comparison of industries with and without TRI exposure, a significant excess risk was estimated for the longest held job in TRI‐exposing industries (odds ratio (OR) 1.80, 95% confidence interval (CI) 1.01–3.20). Any exposure in “metal degreasing” was a RCC risk factor (OR 5.57, 95% CI 2.33–13.32). Self‐reported narcotic symptoms, indicative of peak exposures, were associated with an excess risk (OR 3.71, 95% CI 1.80–7.54).
Conclusions
The study supports the human nephrocarcinogenicity of trichloroethylene. Am. J. Ind. Med. 43:274–285, 2003. © 2003 Wiley‐Liss, Inc.</abstract><cop>New York</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>12594774</pmid><doi>10.1002/ajim.10185</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Biological and medical sciences Carcinoma, Renal Cell - chemically induced Carcinoma, Renal Cell - epidemiology Case-Control Studies case-control study Female Germany - epidemiology Humans Interviews as Topic job-exposure matrix Kidney Neoplasms - chemically induced Kidney Neoplasms - epidemiology Kidneys Logistic Models Male Medical sciences Metallurgy nephrocarcinogenicity Nephrology. Urinary tract diseases occupational exposure Occupational Exposure - adverse effects Occupations - statistics & numerical data renal cell carcinoma Risk Factors Solvents - adverse effects trichloroethene trichloroethylene Trichloroethylene - adverse effects Tumors of the urinary system |
| title | Renal cell cancer risk and occupational exposure to trichloroethylene: Results of a consecutive case-control study in Arnsberg, Germany |
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