Porphyromonas gingivalis antibody levels and diagnosis of coronary artery disease in HIV‐positive individuals
Background and Objective Periodontal disease has been associated with cardiovascular disease in the general population. It is unknown whether IgG antibody levels for periodontal pathogens are associated with the diagnosis of coronary artery disease (CAD) in HIV‐positive individuals. Material and Met...
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| Veröffentlicht in: | Journal of periodontal research 2017-10, Vol.52 (5), p.930-935 |
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| creator | Berquist, V. L. Hearps, A. C. Ford, P. Jaworowski, A. Leishman, S. J. Hoy, J. F. Trevillyan, J. M. |
| description | Background and Objective
Periodontal disease has been associated with cardiovascular disease in the general population. It is unknown whether IgG antibody levels for periodontal pathogens are associated with the diagnosis of coronary artery disease (CAD) in HIV‐positive individuals.
Material and Methods
Twenty‐four HIV‐positive individuals (cases) with stored plasma available in the 12 months before CAD diagnosis were age‐ and sex‐matched 1:2 with 46 HIV‐positive individuals without CAD (controls). Antibody levels to whole cell extracts from periodontal pathogens Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans and Fusobacterium nucleatum, as well as markers of inflammation sCD14, CXCL10 and high‐sensitivity C‐reactive protein, were compared between cases and controls using enzyme‐linked immunosorbent assays.
Results
P. gingivalis‐specific IgG levels (μg/mL) were significantly higher in individuals with CAD (median 1.48 [IQR 1.06‐2.05]) compared to controls (0.70 [IQR 0.35‐1.24], P |
| doi_str_mv | 10.1111/jre.12460 |
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Periodontal disease has been associated with cardiovascular disease in the general population. It is unknown whether IgG antibody levels for periodontal pathogens are associated with the diagnosis of coronary artery disease (CAD) in HIV‐positive individuals.
Material and Methods
Twenty‐four HIV‐positive individuals (cases) with stored plasma available in the 12 months before CAD diagnosis were age‐ and sex‐matched 1:2 with 46 HIV‐positive individuals without CAD (controls). Antibody levels to whole cell extracts from periodontal pathogens Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans and Fusobacterium nucleatum, as well as markers of inflammation sCD14, CXCL10 and high‐sensitivity C‐reactive protein, were compared between cases and controls using enzyme‐linked immunosorbent assays.
Results
P. gingivalis‐specific IgG levels (μg/mL) were significantly higher in individuals with CAD (median 1.48 [IQR 1.06‐2.05]) compared to controls (0.70 [IQR 0.35‐1.24], P<.001), and remained significantly higher following adjustment for traditional cardiovascular risk factors and HIV viral load (OR 21.6 [95% CI 3.73‐125.63] P=.001). There was a borderline association between A. actinomycetemcomitans IgG antibody levels (cases, median 3.86 [IQR 3.19‐4.72]; controls, 3.34 [IQR 2.59‐4.07], P=.050) and no association found between F. nucleatum antibody levels and CAD. sCD14 levels (μg/mL) were higher in cases compared with controls (median 3.45 [IQR 3.03‐4.11] vs 2.65 [IQR 2.32‐2.99] P<.001), while CXCL10 (median 127 pg/mL [IQR 88‐157] vs 153 [IQR 90‐244] P=.321) and high‐sensitivity C‐reactive protein (median 3.44 mg/L [1.98‐5.32] vs 1.85 [1.13‐6.88] P=.203) levels were not different between cases and controls.
Conclusion
Periodontal bacteria may be contributing to CAD risk in HIV‐positive individuals.</description><identifier>ISSN: 0022-3484</identifier><identifier>EISSN: 1600-0765</identifier><identifier>DOI: 10.1111/jre.12460</identifier><identifier>PMID: 28397248</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Adult ; Aggregatibacter actinomycetemcomitans - immunology ; Aggregatibacter actinomycetemcomitans - pathogenicity ; Antibodies, Bacterial - blood ; Antigens, Bacterial - immunology ; Australia ; Biomarkers - blood ; C-Reactive Protein ; Cardiovascular disease ; Cardiovascular diseases ; Case-Control Studies ; Chemokine CXCL10 - blood ; Coronary artery ; coronary artery disease ; Coronary Artery Disease - blood ; Coronary Artery Disease - complications ; Coronary Artery Disease - diagnosis ; Coronary vessels ; CXCL10 protein ; Dentistry ; Diagnosis ; Female ; Fusobacterium nucleatum - immunology ; Fusobacterium nucleatum - pathogenicity ; Health risk assessment ; Heart diseases ; HIV ; HIV Infections - complications ; Human immunodeficiency virus ; Humans ; Immunoglobulin G ; Immunoglobulin G - blood ; inflammation ; Inflammation - immunology ; Lipopolysaccharide Receptors - blood ; Male ; Middle Aged ; Pathogens ; periodontal disease ; Periodontal Diseases - complications ; Periodontal Diseases - microbiology ; Periodontics ; Pilot Projects ; Porphyromonas gingivalis - immunology ; Porphyromonas gingivalis - pathogenicity ; Risk Assessment ; Risk Factors ; Viral Load</subject><ispartof>Journal of periodontal research, 2017-10, Vol.52 (5), p.930-935</ispartof><rights>2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd</rights><rights>2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.</rights><rights>Copyright © 2017 John Wiley & Sons A/S</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3530-cf4a923685377aa583acc547338ce0a627078ff7c267706faf45fb0023c3522c3</citedby><cites>FETCH-LOGICAL-c3530-cf4a923685377aa583acc547338ce0a627078ff7c267706faf45fb0023c3522c3</cites><orcidid>0000-0002-8660-5558</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fjre.12460$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fjre.12460$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,781,785,1418,27929,27930,45579,45580</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28397248$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Berquist, V. L.</creatorcontrib><creatorcontrib>Hearps, A. C.</creatorcontrib><creatorcontrib>Ford, P.</creatorcontrib><creatorcontrib>Jaworowski, A.</creatorcontrib><creatorcontrib>Leishman, S. J.</creatorcontrib><creatorcontrib>Hoy, J. F.</creatorcontrib><creatorcontrib>Trevillyan, J. M.</creatorcontrib><title>Porphyromonas gingivalis antibody levels and diagnosis of coronary artery disease in HIV‐positive individuals</title><title>Journal of periodontal research</title><addtitle>J Periodontal Res</addtitle><description>Background and Objective
Periodontal disease has been associated with cardiovascular disease in the general population. It is unknown whether IgG antibody levels for periodontal pathogens are associated with the diagnosis of coronary artery disease (CAD) in HIV‐positive individuals.
Material and Methods
Twenty‐four HIV‐positive individuals (cases) with stored plasma available in the 12 months before CAD diagnosis were age‐ and sex‐matched 1:2 with 46 HIV‐positive individuals without CAD (controls). Antibody levels to whole cell extracts from periodontal pathogens Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans and Fusobacterium nucleatum, as well as markers of inflammation sCD14, CXCL10 and high‐sensitivity C‐reactive protein, were compared between cases and controls using enzyme‐linked immunosorbent assays.
Results
P. gingivalis‐specific IgG levels (μg/mL) were significantly higher in individuals with CAD (median 1.48 [IQR 1.06‐2.05]) compared to controls (0.70 [IQR 0.35‐1.24], P<.001), and remained significantly higher following adjustment for traditional cardiovascular risk factors and HIV viral load (OR 21.6 [95% CI 3.73‐125.63] P=.001). There was a borderline association between A. actinomycetemcomitans IgG antibody levels (cases, median 3.86 [IQR 3.19‐4.72]; controls, 3.34 [IQR 2.59‐4.07], P=.050) and no association found between F. nucleatum antibody levels and CAD. sCD14 levels (μg/mL) were higher in cases compared with controls (median 3.45 [IQR 3.03‐4.11] vs 2.65 [IQR 2.32‐2.99] P<.001), while CXCL10 (median 127 pg/mL [IQR 88‐157] vs 153 [IQR 90‐244] P=.321) and high‐sensitivity C‐reactive protein (median 3.44 mg/L [1.98‐5.32] vs 1.85 [1.13‐6.88] P=.203) levels were not different between cases and controls.
Conclusion
Periodontal bacteria may be contributing to CAD risk in HIV‐positive individuals.</description><subject>Adult</subject><subject>Aggregatibacter actinomycetemcomitans - immunology</subject><subject>Aggregatibacter actinomycetemcomitans - pathogenicity</subject><subject>Antibodies, Bacterial - blood</subject><subject>Antigens, Bacterial - immunology</subject><subject>Australia</subject><subject>Biomarkers - blood</subject><subject>C-Reactive Protein</subject><subject>Cardiovascular disease</subject><subject>Cardiovascular diseases</subject><subject>Case-Control Studies</subject><subject>Chemokine CXCL10 - blood</subject><subject>Coronary artery</subject><subject>coronary artery disease</subject><subject>Coronary Artery Disease - blood</subject><subject>Coronary Artery Disease - complications</subject><subject>Coronary Artery Disease - diagnosis</subject><subject>Coronary vessels</subject><subject>CXCL10 protein</subject><subject>Dentistry</subject><subject>Diagnosis</subject><subject>Female</subject><subject>Fusobacterium nucleatum - immunology</subject><subject>Fusobacterium nucleatum - pathogenicity</subject><subject>Health risk assessment</subject><subject>Heart diseases</subject><subject>HIV</subject><subject>HIV Infections - complications</subject><subject>Human immunodeficiency virus</subject><subject>Humans</subject><subject>Immunoglobulin G</subject><subject>Immunoglobulin G - blood</subject><subject>inflammation</subject><subject>Inflammation - immunology</subject><subject>Lipopolysaccharide Receptors - blood</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Pathogens</subject><subject>periodontal disease</subject><subject>Periodontal Diseases - complications</subject><subject>Periodontal Diseases - microbiology</subject><subject>Periodontics</subject><subject>Pilot Projects</subject><subject>Porphyromonas gingivalis - immunology</subject><subject>Porphyromonas gingivalis - pathogenicity</subject><subject>Risk Assessment</subject><subject>Risk Factors</subject><subject>Viral Load</subject><issn>0022-3484</issn><issn>1600-0765</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kcFOAjEQhhujEUQPvoDZxIseFrrt7rYcDUHBkGiMem1Kt8WSZYstu4abj-Az-iQOgh5M7OXPtN_8memP0GmCuwmc3tzrbkLSHO-hdpJjHGOWZ_uojTEhMU152kJHIcwx1DnrH6IW4bTPSMrbyN07v3xZe7dwlQzRzFYz28jShkhWKzt1xToqdaPLTV1EhZWzygV4dSZSzkOPX0fSrzRIYYOWQUe2ikbj58_3jyWQK9tsbgrb2KKWZThGBwZEn-y0g56uh4-DUTy5uxkPriaxohnFsTKp7BOa84wyJmXGqVQqSxmlXGksc8Iw48YwBQsxnBtp0sxMYT8K_YQo2kEXW9-ld6-1DiuxsEHpspSVdnUQCec5y2hCGaDnf9C5q30F04mkv3FLcUaButxSyrsQvDZi6e0C1hcJFpsUBKQgvlMA9mznWE8Xuvglf74dgN4WeLOlXv_vJG4fhlvLL9FAkpM</recordid><startdate>201710</startdate><enddate>201710</enddate><creator>Berquist, V. L.</creator><creator>Hearps, A. C.</creator><creator>Ford, P.</creator><creator>Jaworowski, A.</creator><creator>Leishman, S. J.</creator><creator>Hoy, J. F.</creator><creator>Trevillyan, J. M.</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-8660-5558</orcidid></search><sort><creationdate>201710</creationdate><title>Porphyromonas gingivalis antibody levels and diagnosis of coronary artery disease in HIV‐positive individuals</title><author>Berquist, V. L. ; Hearps, A. C. ; Ford, P. ; Jaworowski, A. ; Leishman, S. J. ; Hoy, J. F. ; Trevillyan, J. M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3530-cf4a923685377aa583acc547338ce0a627078ff7c267706faf45fb0023c3522c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adult</topic><topic>Aggregatibacter actinomycetemcomitans - immunology</topic><topic>Aggregatibacter actinomycetemcomitans - pathogenicity</topic><topic>Antibodies, Bacterial - blood</topic><topic>Antigens, Bacterial - immunology</topic><topic>Australia</topic><topic>Biomarkers - blood</topic><topic>C-Reactive Protein</topic><topic>Cardiovascular disease</topic><topic>Cardiovascular diseases</topic><topic>Case-Control Studies</topic><topic>Chemokine CXCL10 - blood</topic><topic>Coronary artery</topic><topic>coronary artery disease</topic><topic>Coronary Artery Disease - blood</topic><topic>Coronary Artery Disease - complications</topic><topic>Coronary Artery Disease - diagnosis</topic><topic>Coronary vessels</topic><topic>CXCL10 protein</topic><topic>Dentistry</topic><topic>Diagnosis</topic><topic>Female</topic><topic>Fusobacterium nucleatum - immunology</topic><topic>Fusobacterium nucleatum - pathogenicity</topic><topic>Health risk assessment</topic><topic>Heart diseases</topic><topic>HIV</topic><topic>HIV Infections - complications</topic><topic>Human immunodeficiency virus</topic><topic>Humans</topic><topic>Immunoglobulin G</topic><topic>Immunoglobulin G - blood</topic><topic>inflammation</topic><topic>Inflammation - immunology</topic><topic>Lipopolysaccharide Receptors - blood</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Pathogens</topic><topic>periodontal disease</topic><topic>Periodontal Diseases - complications</topic><topic>Periodontal Diseases - microbiology</topic><topic>Periodontics</topic><topic>Pilot Projects</topic><topic>Porphyromonas gingivalis - immunology</topic><topic>Porphyromonas gingivalis - pathogenicity</topic><topic>Risk Assessment</topic><topic>Risk Factors</topic><topic>Viral Load</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Berquist, V. L.</creatorcontrib><creatorcontrib>Hearps, A. C.</creatorcontrib><creatorcontrib>Ford, P.</creatorcontrib><creatorcontrib>Jaworowski, A.</creatorcontrib><creatorcontrib>Leishman, S. J.</creatorcontrib><creatorcontrib>Hoy, J. F.</creatorcontrib><creatorcontrib>Trevillyan, J. M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of periodontal research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Berquist, V. L.</au><au>Hearps, A. C.</au><au>Ford, P.</au><au>Jaworowski, A.</au><au>Leishman, S. J.</au><au>Hoy, J. F.</au><au>Trevillyan, J. M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Porphyromonas gingivalis antibody levels and diagnosis of coronary artery disease in HIV‐positive individuals</atitle><jtitle>Journal of periodontal research</jtitle><addtitle>J Periodontal Res</addtitle><date>2017-10</date><risdate>2017</risdate><volume>52</volume><issue>5</issue><spage>930</spage><epage>935</epage><pages>930-935</pages><issn>0022-3484</issn><eissn>1600-0765</eissn><abstract>Background and Objective
Periodontal disease has been associated with cardiovascular disease in the general population. It is unknown whether IgG antibody levels for periodontal pathogens are associated with the diagnosis of coronary artery disease (CAD) in HIV‐positive individuals.
Material and Methods
Twenty‐four HIV‐positive individuals (cases) with stored plasma available in the 12 months before CAD diagnosis were age‐ and sex‐matched 1:2 with 46 HIV‐positive individuals without CAD (controls). Antibody levels to whole cell extracts from periodontal pathogens Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans and Fusobacterium nucleatum, as well as markers of inflammation sCD14, CXCL10 and high‐sensitivity C‐reactive protein, were compared between cases and controls using enzyme‐linked immunosorbent assays.
Results
P. gingivalis‐specific IgG levels (μg/mL) were significantly higher in individuals with CAD (median 1.48 [IQR 1.06‐2.05]) compared to controls (0.70 [IQR 0.35‐1.24], P<.001), and remained significantly higher following adjustment for traditional cardiovascular risk factors and HIV viral load (OR 21.6 [95% CI 3.73‐125.63] P=.001). There was a borderline association between A. actinomycetemcomitans IgG antibody levels (cases, median 3.86 [IQR 3.19‐4.72]; controls, 3.34 [IQR 2.59‐4.07], P=.050) and no association found between F. nucleatum antibody levels and CAD. sCD14 levels (μg/mL) were higher in cases compared with controls (median 3.45 [IQR 3.03‐4.11] vs 2.65 [IQR 2.32‐2.99] P<.001), while CXCL10 (median 127 pg/mL [IQR 88‐157] vs 153 [IQR 90‐244] P=.321) and high‐sensitivity C‐reactive protein (median 3.44 mg/L [1.98‐5.32] vs 1.85 [1.13‐6.88] P=.203) levels were not different between cases and controls.
Conclusion
Periodontal bacteria may be contributing to CAD risk in HIV‐positive individuals.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>28397248</pmid><doi>10.1111/jre.12460</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-8660-5558</orcidid></addata></record> |
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| subjects | Adult Aggregatibacter actinomycetemcomitans - immunology Aggregatibacter actinomycetemcomitans - pathogenicity Antibodies, Bacterial - blood Antigens, Bacterial - immunology Australia Biomarkers - blood C-Reactive Protein Cardiovascular disease Cardiovascular diseases Case-Control Studies Chemokine CXCL10 - blood Coronary artery coronary artery disease Coronary Artery Disease - blood Coronary Artery Disease - complications Coronary Artery Disease - diagnosis Coronary vessels CXCL10 protein Dentistry Diagnosis Female Fusobacterium nucleatum - immunology Fusobacterium nucleatum - pathogenicity Health risk assessment Heart diseases HIV HIV Infections - complications Human immunodeficiency virus Humans Immunoglobulin G Immunoglobulin G - blood inflammation Inflammation - immunology Lipopolysaccharide Receptors - blood Male Middle Aged Pathogens periodontal disease Periodontal Diseases - complications Periodontal Diseases - microbiology Periodontics Pilot Projects Porphyromonas gingivalis - immunology Porphyromonas gingivalis - pathogenicity Risk Assessment Risk Factors Viral Load |
| title | Porphyromonas gingivalis antibody levels and diagnosis of coronary artery disease in HIV‐positive individuals |
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