Insulin, not glutamine dipeptide, reduces lipases expression and prevents fat wasting and weight loss in Walker 256 tumor-bearing rats

Cachexia is the main cause of mortality in advanced cancer patients. We investigated the effects of insulin (INS) and glutamine dipeptide (GDP), isolated or associated, on cachexia and metabolic changes induced by Walker 256 tumor in rats. INS (NPH, 40 UI/kg, sc) or GDP (1.5g/kg, oral gavage) was on...

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Veröffentlicht in:	European journal of pharmacology 2017-07, Vol.806, p.67-74
Hauptverfasser:	de Morais, Hely, de Fatima Silva, Flaviane, da Silva, Francemilson Goulart, Silva, Milene Ortiz, Graciano, Maria Fernanda Rodrigues, Martins, Maria Isabel Lovo, Carpinelli, Ângelo Rafael, Mazucco, Tânia Longo, Bazotte, Roberto Barbosa, de Souza, Helenir Medri
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipose Tissue - drug effects Adipose Tissue - metabolism Animals Cachexia Cachexia - complications Cachexia - prevention & control Cancer Cell Line, Tumor Cytokines Gene Expression Regulation, Enzymologic - drug effects Insulin - pharmacology Insulin resistance Interleukin-6 - metabolism Lipase - metabolism Male Mammary Neoplasms, Animal - complications Mammary Neoplasms, Animal - enzymology Mammary Neoplasms, Animal - pathology Mammary Neoplasms, Animal - physiopathology Metabolic disorders Rats Rats, Wistar Tumor Necrosis Factor-alpha - metabolism Weight Loss - drug effects
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