Ingestion of dug well water from an area with high prevalence of chronic kidney disease of unknown etiology (CKDu) and development of kidney and liver lesions in rats
Chronic kidney disease of unknown aetiology (CKDu) is prevalent in the North Central Province (NCP) of Sri Lanka and ingestion of dug well water is considered a potential causative factor. Three CKDu prevalent villages were selected from the NCP based on the number of CKDu patients in the locality....
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| Veröffentlicht in: | Ceylon medical journal 2017-03, Vol.62 (1), p.20-24 |
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| container_title | Ceylon medical journal |
| container_volume | 62 |
| creator | Thammitiyagodage, M G Gunatillaka, M M Ekanayaka, N Rathnayake, C Horadagoda, N U Jayathissa, R Gunaratne, U K Kumara, W G Abeynayake, P |
| description | Chronic kidney disease of unknown aetiology
(CKDu) is prevalent in the North Central Province (NCP) of
Sri Lanka and ingestion of dug well water is considered a
potential causative factor. Three CKDu prevalent villages
were selected from the NCP based on the number of CKDu
patients in the locality.
Forty Wistar rats were divided into four groups
with 10 rats each. Group No 1, 2 and 3 were given water
from selected dug wells. Control group was given tap water
from Colombo. Water samples were analysed for fluoride,
iron, arsenic, cadmium and calcium. Histopathological
examination of liver and kidney tissues were performed.
Significant reduction of glomerular filtration rate
(GFR) was observed in two test groups compared to the
control group (p0.05). In one group hepatocellular carcinoma
with elevated serum liver enzymes was observed
whilst hepatitis was observed in another test group (p |
| doi_str_mv | 10.4038/cmj.v62i1.8428 |
| format | Article |
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(CKDu) is prevalent in the North Central Province (NCP) of
Sri Lanka and ingestion of dug well water is considered a
potential causative factor. Three CKDu prevalent villages
were selected from the NCP based on the number of CKDu
patients in the locality.
Forty Wistar rats were divided into four groups
with 10 rats each. Group No 1, 2 and 3 were given water
from selected dug wells. Control group was given tap water
from Colombo. Water samples were analysed for fluoride,
iron, arsenic, cadmium and calcium. Histopathological
examination of liver and kidney tissues were performed.
Significant reduction of glomerular filtration rate
(GFR) was observed in two test groups compared to the
control group (p0.05). In one group hepatocellular carcinoma
with elevated serum liver enzymes was observed
whilst hepatitis was observed in another test group (p<0.05).
But mixed lesions were common in all affected rats.
Significantly high renal tubular lesion index was observed
in all three experimental groups (p<0.05) and high
glomerular lesion index (p=0.017) was observed in one test
group. Cadmium, arsenic and iron contents were below
detectable levels in the NCP water sources and tap water
from Colombo.
Different wells may have different concentrations
of environmental toxins and depending on the
severity of the toxin contents GFR and grade and type of
liver and kidney lesions may vary. High fluoride and other
undetected toxins in shallow dug wells may be the causative
factors for renal and liver lesions in these Wistar rats.</description><identifier>ISSN: 0009-0875</identifier><identifier>EISSN: 2386-1274</identifier><identifier>DOI: 10.4038/cmj.v62i1.8428</identifier><identifier>PMID: 28390327</identifier><language>eng</language><publisher>Sri Lanka</publisher><ispartof>Ceylon medical journal, 2017-03, Vol.62 (1), p.20-24</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c265t-aef217c47252e6fd35aa9069f84742e502d5e9c5b98ea2318511d869359083fd3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28390327$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Thammitiyagodage, M G</creatorcontrib><creatorcontrib>Gunatillaka, M M</creatorcontrib><creatorcontrib>Ekanayaka, N</creatorcontrib><creatorcontrib>Rathnayake, C</creatorcontrib><creatorcontrib>Horadagoda, N U</creatorcontrib><creatorcontrib>Jayathissa, R</creatorcontrib><creatorcontrib>Gunaratne, U K</creatorcontrib><creatorcontrib>Kumara, W G</creatorcontrib><creatorcontrib>Abeynayake, P</creatorcontrib><title>Ingestion of dug well water from an area with high prevalence of chronic kidney disease of unknown etiology (CKDu) and development of kidney and liver lesions in rats</title><title>Ceylon medical journal</title><addtitle>Ceylon Med J</addtitle><description>Chronic kidney disease of unknown aetiology
(CKDu) is prevalent in the North Central Province (NCP) of
Sri Lanka and ingestion of dug well water is considered a
potential causative factor. Three CKDu prevalent villages
were selected from the NCP based on the number of CKDu
patients in the locality.
Forty Wistar rats were divided into four groups
with 10 rats each. Group No 1, 2 and 3 were given water
from selected dug wells. Control group was given tap water
from Colombo. Water samples were analysed for fluoride,
iron, arsenic, cadmium and calcium. Histopathological
examination of liver and kidney tissues were performed.
Significant reduction of glomerular filtration rate
(GFR) was observed in two test groups compared to the
control group (p0.05). In one group hepatocellular carcinoma
with elevated serum liver enzymes was observed
whilst hepatitis was observed in another test group (p<0.05).
But mixed lesions were common in all affected rats.
Significantly high renal tubular lesion index was observed
in all three experimental groups (p<0.05) and high
glomerular lesion index (p=0.017) was observed in one test
group. Cadmium, arsenic and iron contents were below
detectable levels in the NCP water sources and tap water
from Colombo.
Different wells may have different concentrations
of environmental toxins and depending on the
severity of the toxin contents GFR and grade and type of
liver and kidney lesions may vary. High fluoride and other
undetected toxins in shallow dug wells may be the causative
factors for renal and liver lesions in these Wistar rats.</description><issn>0009-0875</issn><issn>2386-1274</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNo9kU1v1DAQhi0EokvhyhHNsRyy-CN2nCNaPlpRiQucI9ee7LpN7MVOdrV_iN-J0245-TDP-441DyHvGV3XVOhPdrxfHxT3bK1rrl-QFRdaVYw39UuyopS2FdWNvCBvcr6nJUBp85pccC1aKnizIn9vwhbz5GOA2IObt3DEYYCjmTBBn-IIJoBJaODopx3s_HYH-4QHM2CwuGTsLsXgLTx4F_AEzmc0-XEyh4cQjwGw1A9xe4KrzY8v88fS6MDhAYe4HzFMC3oOL5PBH8rqAXP5UwYfIJkpvyWvejNkfHd-L8nvb19_ba6r25_fbzafbyvLlZwqgz1nja0bLjmq3glpTEtV2-u6qTlKyp3E1sq7VqPhgmnJmNOqFbKlWhT-klw99e5T_DOXw3Sjz7ZcxASMc-6Y1kpIRVVd0PUTalPMOWHf7ZMfTTp1jHaLm6646R7ddIubEvhw7p7vRnT_8WcZ4h_qWo0L</recordid><startdate>20170331</startdate><enddate>20170331</enddate><creator>Thammitiyagodage, M G</creator><creator>Gunatillaka, M M</creator><creator>Ekanayaka, N</creator><creator>Rathnayake, C</creator><creator>Horadagoda, N U</creator><creator>Jayathissa, R</creator><creator>Gunaratne, U K</creator><creator>Kumara, W G</creator><creator>Abeynayake, P</creator><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20170331</creationdate><title>Ingestion of dug well water from an area with high prevalence of chronic kidney disease of unknown etiology (CKDu) and development of kidney and liver lesions in rats</title><author>Thammitiyagodage, M G ; Gunatillaka, M M ; Ekanayaka, N ; Rathnayake, C ; Horadagoda, N U ; Jayathissa, R ; Gunaratne, U K ; Kumara, W G ; Abeynayake, P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c265t-aef217c47252e6fd35aa9069f84742e502d5e9c5b98ea2318511d869359083fd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Thammitiyagodage, M G</creatorcontrib><creatorcontrib>Gunatillaka, M M</creatorcontrib><creatorcontrib>Ekanayaka, N</creatorcontrib><creatorcontrib>Rathnayake, C</creatorcontrib><creatorcontrib>Horadagoda, N U</creatorcontrib><creatorcontrib>Jayathissa, R</creatorcontrib><creatorcontrib>Gunaratne, U K</creatorcontrib><creatorcontrib>Kumara, W G</creatorcontrib><creatorcontrib>Abeynayake, P</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Ceylon medical journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Thammitiyagodage, M G</au><au>Gunatillaka, M M</au><au>Ekanayaka, N</au><au>Rathnayake, C</au><au>Horadagoda, N U</au><au>Jayathissa, R</au><au>Gunaratne, U K</au><au>Kumara, W G</au><au>Abeynayake, P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ingestion of dug well water from an area with high prevalence of chronic kidney disease of unknown etiology (CKDu) and development of kidney and liver lesions in rats</atitle><jtitle>Ceylon medical journal</jtitle><addtitle>Ceylon Med J</addtitle><date>2017-03-31</date><risdate>2017</risdate><volume>62</volume><issue>1</issue><spage>20</spage><epage>24</epage><pages>20-24</pages><issn>0009-0875</issn><eissn>2386-1274</eissn><abstract>Chronic kidney disease of unknown aetiology
(CKDu) is prevalent in the North Central Province (NCP) of
Sri Lanka and ingestion of dug well water is considered a
potential causative factor. Three CKDu prevalent villages
were selected from the NCP based on the number of CKDu
patients in the locality.
Forty Wistar rats were divided into four groups
with 10 rats each. Group No 1, 2 and 3 were given water
from selected dug wells. Control group was given tap water
from Colombo. Water samples were analysed for fluoride,
iron, arsenic, cadmium and calcium. Histopathological
examination of liver and kidney tissues were performed.
Significant reduction of glomerular filtration rate
(GFR) was observed in two test groups compared to the
control group (p0.05). In one group hepatocellular carcinoma
with elevated serum liver enzymes was observed
whilst hepatitis was observed in another test group (p<0.05).
But mixed lesions were common in all affected rats.
Significantly high renal tubular lesion index was observed
in all three experimental groups (p<0.05) and high
glomerular lesion index (p=0.017) was observed in one test
group. Cadmium, arsenic and iron contents were below
detectable levels in the NCP water sources and tap water
from Colombo.
Different wells may have different concentrations
of environmental toxins and depending on the
severity of the toxin contents GFR and grade and type of
liver and kidney lesions may vary. High fluoride and other
undetected toxins in shallow dug wells may be the causative
factors for renal and liver lesions in these Wistar rats.</abstract><cop>Sri Lanka</cop><pmid>28390327</pmid><doi>10.4038/cmj.v62i1.8428</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| title | Ingestion of dug well water from an area with high prevalence of chronic kidney disease of unknown etiology (CKDu) and development of kidney and liver lesions in rats |
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