Manipulation of dopamine metabolism contributes to attenuating innate high locomotor activity in ICR mice

•ICR mice showed higher locomotor activity compared with C57BL/6J and CBA/N mice.•DA content in the cerebellum and striatum was lower in ICR than in C57BL/6J mice.•BH4 administration increased the DA or DA metabolite in some brain regions.•The DA metabolism enhanced by L-DOPA administration attenuat...

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Veröffentlicht in:	Behavioural brain research 2017-06, Vol.328, p.227-234
Hauptverfasser:	Yamaguchi, Takeshi, Nagasawa, Mao, Ikeda, Hiromi, Kodaira, Momoko, Minaminaka, Kimie, Chowdhury, Vishwajit S., Yasuo, Shinobu, Furuse, Mitsuhiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of Variance Animals BH4 Brain - drug effects Brain - metabolism Dopamine - metabolism Dopamine Agents - pharmacology Dose-Response Relationship, Drug L-DOPA Levodopa - pharmacology Locomotor activity Male Mice Mice, Inbred C57BL - metabolism Mice, Inbred CBA - metabolism Mice, Inbred ICR - metabolism Motor Activity - drug effects Motor Activity - physiology Species Specificity
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