Actions of PGLa-AM1 and its [A14K] and [A20K] analogues and their therapeutic potential as anti-diabetic agents

PGLa-AM1 (GMASKAGSVL10GKVAKVALKA20AL.NH2) was first identified in skin secretions of the frog Xenopus amieti (Pipidae) on the basis of its antimicrobial properties. PGLa-AM1 and its [A14K] and [A20K] analogues produced a concentration-dependent stimulation of insulin release from BRIN-BD11 rat clona...

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Veröffentlicht in:	Biochimie 2017-07, Vol.138, p.1-12
Hauptverfasser:	Owolabi, Bosede O., Musale, Vishal, Ojo, Opeolu O., Moffett, R. Charlotte, McGahon, Mary K., Curtis, Tim M., Conlon, J. Michael, Flatt, Peter R., Abdel-Wahab, Yasser H.A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amphibian Proteins - therapeutic use Amphibian skin peptide Animals Anti-apoptotic peptide Antimicrobial Cationic Peptides - therapeutic use Calcium - metabolism Cell Line Cyclic AMP-Dependent Protein Kinases - drug effects Cyclic AMP-Dependent Protein Kinases - genetics Down-Regulation Humans Hypoglycemic Agents - therapeutic use Insulin - metabolism Insulin Secretion Insulin-release Insulin-Secreting Cells - drug effects Insulin-Secreting Cells - metabolism Mice PGLa-AM1 Pipidae Rats Signal Transduction Type 2 diabetes Xenopus Proteins - therapeutic use β-Cell proliferation
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