Preparation of functional human lysophosphatidic acid receptor 2 using a P9∗ expression system and an amphipathic polymer and investigation of its in vitro binding preference to Gα proteins

Human lysophosphatidic acid receptor 2 (LPA2), a member of the G-protein coupled receptor family, mediates lysophosphatidic acid (LPA)-dependent signaling by recruiting various G proteins. Particularly, it is directly implicated in the progression of colorectal and ovarian cancer through G protein s...

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Veröffentlicht in:	Biochemical and biophysical research communications 2017-05, Vol.487 (1), p.103-108
Hauptverfasser:	Han, Seong-Gu, Baek, Seung-Il, Son, Tae Jin, Lee, Hyeongjin, Kim, Nam Hyuk, Yu, Yeon Gyu
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding Sites Cloning, Molecular - methods Escherichia coli - genetics Escherichia coli - metabolism G-protein GPCR GTP-Binding Protein alpha Subunits - chemistry Humans Infectious Anemia Virus, Equine - genetics Lysophosphatidic acid receptor 2 Protein Binding Receptors, Lysophosphatidic Acid - chemistry Receptors, Lysophosphatidic Acid - physiology
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