Oral submucous fibrosis: An update on pathophysiology of malignant transformation

Oral submucous fibrosis (OSMF) is a potentially malignant condition associated with areca nut chewing. Formerly confined to the Indian subcontinent, it is now often seen in Asian populations of the United Kingdom, USA and other developed countries, and is therefore a serious problem for global healt...

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Veröffentlicht in:Journal of oral pathology & medicine 2017-07, Vol.46 (6), p.413-417
Hauptverfasser: Arakeri, Gururaj, Patil, Shekar Gowda, Aljabab, Abdulsalam S., Lin, Kuan‐Chou, Merkx, M. A. W., Gao, Shan, Brennan, Peter A.
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container_end_page 417
container_issue 6
container_start_page 413
container_title Journal of oral pathology & medicine
container_volume 46
creator Arakeri, Gururaj
Patil, Shekar Gowda
Aljabab, Abdulsalam S.
Lin, Kuan‐Chou
Merkx, M. A. W.
Gao, Shan
Brennan, Peter A.
description Oral submucous fibrosis (OSMF) is a potentially malignant condition associated with areca nut chewing. Formerly confined to the Indian subcontinent, it is now often seen in Asian populations of the United Kingdom, USA and other developed countries, and is therefore a serious problem for global health. What makes it more sinister is the malignant transformation rate, which has been reported to be around 7.6% over a 17‐year period. In this concise article, we review the current trends in the pathophysiology of malignant transformation of OSMF.
doi_str_mv 10.1111/jop.12582
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source MEDLINE; Wiley Online Library Journals Frontfile Complete
subjects Areca - adverse effects
Carcinoma, Squamous Cell - pathology
Cell Transformation, Neoplastic - pathology
Chewing
Dentistry
Fibrosis
Humans
malignant transformation
Mouth Neoplasms - pathology
oral submucous fibrosis
Oral Submucous Fibrosis - pathology
Precancerous Conditions
review
squamous cell carcinoma
title Oral submucous fibrosis: An update on pathophysiology of malignant transformation
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