Oral submucous fibrosis: An update on pathophysiology of malignant transformation
Oral submucous fibrosis (OSMF) is a potentially malignant condition associated with areca nut chewing. Formerly confined to the Indian subcontinent, it is now often seen in Asian populations of the United Kingdom, USA and other developed countries, and is therefore a serious problem for global healt...
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Veröffentlicht in: | Journal of oral pathology & medicine 2017-07, Vol.46 (6), p.413-417 |
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container_title | Journal of oral pathology & medicine |
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creator | Arakeri, Gururaj Patil, Shekar Gowda Aljabab, Abdulsalam S. Lin, Kuan‐Chou Merkx, M. A. W. Gao, Shan Brennan, Peter A. |
description | Oral submucous fibrosis (OSMF) is a potentially malignant condition associated with areca nut chewing. Formerly confined to the Indian subcontinent, it is now often seen in Asian populations of the United Kingdom, USA and other developed countries, and is therefore a serious problem for global health. What makes it more sinister is the malignant transformation rate, which has been reported to be around 7.6% over a 17‐year period. In this concise article, we review the current trends in the pathophysiology of malignant transformation of OSMF. |
doi_str_mv | 10.1111/jop.12582 |
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A. W. ; Gao, Shan ; Brennan, Peter A.</creator><creatorcontrib>Arakeri, Gururaj ; Patil, Shekar Gowda ; Aljabab, Abdulsalam S. ; Lin, Kuan‐Chou ; Merkx, M. A. W. ; Gao, Shan ; Brennan, Peter A.</creatorcontrib><description>Oral submucous fibrosis (OSMF) is a potentially malignant condition associated with areca nut chewing. Formerly confined to the Indian subcontinent, it is now often seen in Asian populations of the United Kingdom, USA and other developed countries, and is therefore a serious problem for global health. What makes it more sinister is the malignant transformation rate, which has been reported to be around 7.6% over a 17‐year period. In this concise article, we review the current trends in the pathophysiology of malignant transformation of OSMF.</description><identifier>ISSN: 0904-2512</identifier><identifier>EISSN: 1600-0714</identifier><identifier>DOI: 10.1111/jop.12582</identifier><identifier>PMID: 28391621</identifier><language>eng</language><publisher>Denmark: Wiley Subscription Services, Inc</publisher><subject>Areca - adverse effects ; Carcinoma, Squamous Cell - pathology ; Cell Transformation, Neoplastic - pathology ; Chewing ; Dentistry ; Fibrosis ; Humans ; malignant transformation ; Mouth Neoplasms - pathology ; oral submucous fibrosis ; Oral Submucous Fibrosis - pathology ; Precancerous Conditions ; review ; squamous cell carcinoma</subject><ispartof>Journal of oral pathology & medicine, 2017-07, Vol.46 (6), p.413-417</ispartof><rights>2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd</rights><rights>2017 John Wiley & Sons A/S. 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A. W.</creatorcontrib><creatorcontrib>Gao, Shan</creatorcontrib><creatorcontrib>Brennan, Peter A.</creatorcontrib><title>Oral submucous fibrosis: An update on pathophysiology of malignant transformation</title><title>Journal of oral pathology & medicine</title><addtitle>J Oral Pathol Med</addtitle><description>Oral submucous fibrosis (OSMF) is a potentially malignant condition associated with areca nut chewing. Formerly confined to the Indian subcontinent, it is now often seen in Asian populations of the United Kingdom, USA and other developed countries, and is therefore a serious problem for global health. What makes it more sinister is the malignant transformation rate, which has been reported to be around 7.6% over a 17‐year period. In this concise article, we review the current trends in the pathophysiology of malignant transformation of OSMF.</description><subject>Areca - adverse effects</subject><subject>Carcinoma, Squamous Cell - pathology</subject><subject>Cell Transformation, Neoplastic - pathology</subject><subject>Chewing</subject><subject>Dentistry</subject><subject>Fibrosis</subject><subject>Humans</subject><subject>malignant transformation</subject><subject>Mouth Neoplasms - pathology</subject><subject>oral submucous fibrosis</subject><subject>Oral Submucous Fibrosis - pathology</subject><subject>Precancerous Conditions</subject><subject>review</subject><subject>squamous cell carcinoma</subject><issn>0904-2512</issn><issn>1600-0714</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kE1LwzAYgIMobk4P_gEJeNFDXT6aNPU2hp8MpqDnkqbN1tEmNWmR_nszNz0I5vJenvfhzQPAOUY3OLzpxrY3mDBBDsAYc4QilOD4EIxRiuKIMExG4MT7DUI4oTE-BiMiaIo5wWPwunSyhr7Pm17Z3kNd5c76yt_CmYF9W8iuhNbAVnZr264HX9nargZoNWxkXa2MNB3snDReW9fIrrLmFBxpWfvybD8n4P3-7m3-GC2WD0_z2SJSlFESMZanMVMsF0RwpSkVMsVM5SzGMS2owKjgRCqe84KmWlCdIM2QjBOFNE9oQifgaudtnf3oS99lTeVVWdfSlOEnGRaC05hTvkUv_6Ab2zsTrstwSlJBEUI0UNc7SoUC3pU6a13VSDdkGGXbzmGrzb47B_ZibwzlyuKX_AkbgOkO-KzqcvjflD0vX3bKL3ashiE</recordid><startdate>201707</startdate><enddate>201707</enddate><creator>Arakeri, Gururaj</creator><creator>Patil, Shekar Gowda</creator><creator>Aljabab, Abdulsalam S.</creator><creator>Lin, Kuan‐Chou</creator><creator>Merkx, M. A. W.</creator><creator>Gao, Shan</creator><creator>Brennan, Peter A.</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201707</creationdate><title>Oral submucous fibrosis: An update on pathophysiology of malignant transformation</title><author>Arakeri, Gururaj ; Patil, Shekar Gowda ; Aljabab, Abdulsalam S. ; Lin, Kuan‐Chou ; Merkx, M. A. 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A. W.</creatorcontrib><creatorcontrib>Gao, Shan</creatorcontrib><creatorcontrib>Brennan, Peter A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of oral pathology & medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Arakeri, Gururaj</au><au>Patil, Shekar Gowda</au><au>Aljabab, Abdulsalam S.</au><au>Lin, Kuan‐Chou</au><au>Merkx, M. A. W.</au><au>Gao, Shan</au><au>Brennan, Peter A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Oral submucous fibrosis: An update on pathophysiology of malignant transformation</atitle><jtitle>Journal of oral pathology & medicine</jtitle><addtitle>J Oral Pathol Med</addtitle><date>2017-07</date><risdate>2017</risdate><volume>46</volume><issue>6</issue><spage>413</spage><epage>417</epage><pages>413-417</pages><issn>0904-2512</issn><eissn>1600-0714</eissn><abstract>Oral submucous fibrosis (OSMF) is a potentially malignant condition associated with areca nut chewing. Formerly confined to the Indian subcontinent, it is now often seen in Asian populations of the United Kingdom, USA and other developed countries, and is therefore a serious problem for global health. What makes it more sinister is the malignant transformation rate, which has been reported to be around 7.6% over a 17‐year period. 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subjects | Areca - adverse effects Carcinoma, Squamous Cell - pathology Cell Transformation, Neoplastic - pathology Chewing Dentistry Fibrosis Humans malignant transformation Mouth Neoplasms - pathology oral submucous fibrosis Oral Submucous Fibrosis - pathology Precancerous Conditions review squamous cell carcinoma |
title | Oral submucous fibrosis: An update on pathophysiology of malignant transformation |
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