Influence of long-term, high-dose dexamethasone administration on proliferation and apoptosis in porcine hepatocytes

The aim of this study was to examine the influence of long-term, high-dose dexamethasone administration on the liver, with particular emphasis on hepatocyte proliferation and apoptosis, using a swine model. The study included 48 large, female Polish breed pigs aged 3months (weighing ca. 30kg) divide...

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Veröffentlicht in:	Research in veterinary science 2017-06, Vol.112, p.141-148
Hauptverfasser:	Mikiewicz, Mateusz, Otrocka-Domagała, Iwona, Paździor-Czapula, Katarzyna, Rotkiewicz, Tadeusz
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens Apoptosis Apoptosis - drug effects Asthma Bcl-2 protein Caspase Caspase 3 - metabolism Caspase-3 Cell cycle Cell growth Cell Proliferation - drug effects Chromatin Condensation Degeneration Dexamethasone Dexamethasone - administration & dosage Dexamethasone - pharmacology DNA nucleotidylexotransferase Dose-Response Relationship, Drug Drug Administration Schedule Euthanasia Female Gene expression Glucocorticosteroids Glucose Glycogen Hepatocytes Hepatocytes - drug effects Histochemistry Histopathology Hogs Immunohistochemistry Labeling Lipids Liver Livestock Metabolism Nucleoli Phosphate Proliferating cell nuclear antigen Proliferation Rodents Steroids Stretching Swine Transcription Tumor necrosis factor-TNF Veterinary medicine Weighing
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