Netrin-1 improves the amyloid-β-mediated suppression of memory and synaptic plasticity

Highlights • Netrin improves impairments of memory following injection of Aβ. • Netrin improves long term plasticity impairment induced by Aβ. • Netrin participates only in recovery of late phase of LTP. • Netrin does not contribute for induction of early HFS-LTP. • LTP recovery by Netrin in the rat...

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Veröffentlicht in:	Brain research bulletin 2017-05, Vol.131, p.107-116
Hauptverfasser:	Shabani, Mohammad, Haghani, Masoud, Tazangi, Parisa Esmaeili, Bayat, Mahnaz, Shid Moosavi, Seyed Mostafa, Ranjbar, Hoda
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer’s disease Amyloid beta-Peptides - metabolism Animals Beta amyloid Excitatory Postsynaptic Potentials - drug effects Hippocampus - drug effects Learning Disorders - chemically induced Long-term potentiation Long-Term Potentiation - drug effects Male Memory - drug effects Memory Disorders - chemically induced Netrin-1 Netrin-1 - metabolism Netrin-1 - therapeutic use Netrins - metabolism Netrins - pharmacology Neurology Neuronal Plasticity - drug effects Neuropeptides - metabolism Peptide Fragments - metabolism Rats Rats, Sprague-Dawley
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Beschreibung
Zusammenfassung:	Highlights • Netrin improves impairments of memory following injection of Aβ. • Netrin improves long term plasticity impairment induced by Aβ. • Netrin participates only in recovery of late phase of LTP. • Netrin does not contribute for induction of early HFS-LTP. • LTP recovery by Netrin in the rat models of AD is time dependent.
ISSN:	0361-9230 1873-2747
DOI:	10.1016/j.brainresbull.2017.03.015