Runt‐Related Transcription Factor 2 (Runx2) Is Responsible for Galectin‐3 Overexpression in Human Thyroid Carcinoma
ABSTRACT Runx2 promotes metastatic ability of cancer cells by directly activating some of the mediators regarding malignancy. Galectin‐3 (Gal‐3) extensively expressed in normal and transformed cells and it is responsible for many cellular processes. In this study, we aimed to investigate whether the...
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| Veröffentlicht in: | Journal of cellular biochemistry 2017-11, Vol.118 (11), p.3911-3919 |
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| creator | Kaptan, Engin Sancar Bas, Serap Sancakli, Aylin Aktas, Hatice Gumushan Bayrak, Bertan Boran Yanardag, Refiye Bolkent, Sehnaz |
| description | ABSTRACT
Runx2 promotes metastatic ability of cancer cells by directly activating some of the mediators regarding malignancy. Galectin‐3 (Gal‐3) extensively expressed in normal and transformed cells and it is responsible for many cellular processes. In this study, we aimed to investigate whether there is any relationship between runx2 transcription factor and regulation of galectin‐3 expression in different human thyroid carcinoma cell lines. To show effects of runx2 transcription factor on gal‐3 expression, we developed runx2 knockdown model in the thyroid carcinoma cell lines; anaplastic 8505C and 8305C and, papillary TPC‐1 and follicular FTC‐133 by using siRNA transfection. We analyzed the protein expressions and mRNA levels of gal‐3 and MMP2/9 in the runx2‐silenced cell lines using Western blotting, qPCR, and fluorescent microscopy. Our results showed that mRNA expression levels of gal‐3 and MMP2/9 were downregulated in runx2‐silenced cell lines. In this investigation, we revealed that regulation of gal‐3 expression was strongly correlated with runx2 transcription factor in human thyroid carcinoma. Considering the contribution of human gal‐3 in collaboration with MMP2/9 to the malignant characters of many cancers, regulation of their expressions through runx2 seems like one of the key regulatory mechanism for malignant potential of human thyroid carcinoma. Accordingly, runx2 transcription factor inhibitors can be a potential target in order to prevent gal‐3 mediated malignancy of human thyroid carcinoma. J. Cell. Biochem. 118: 3911–3919, 2017. © 2017 Wiley Periodicals, Inc.
Gal‐3 is one of the important contributor of malignancy. In this investigation, we revealed that regulation of gal‐3 expression was strongly correlated with runx2 transcription factor in human thyroid carcinoma. |
| doi_str_mv | 10.1002/jcb.26043 |
| format | Article |
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Runx2 promotes metastatic ability of cancer cells by directly activating some of the mediators regarding malignancy. Galectin‐3 (Gal‐3) extensively expressed in normal and transformed cells and it is responsible for many cellular processes. In this study, we aimed to investigate whether there is any relationship between runx2 transcription factor and regulation of galectin‐3 expression in different human thyroid carcinoma cell lines. To show effects of runx2 transcription factor on gal‐3 expression, we developed runx2 knockdown model in the thyroid carcinoma cell lines; anaplastic 8505C and 8305C and, papillary TPC‐1 and follicular FTC‐133 by using siRNA transfection. We analyzed the protein expressions and mRNA levels of gal‐3 and MMP2/9 in the runx2‐silenced cell lines using Western blotting, qPCR, and fluorescent microscopy. Our results showed that mRNA expression levels of gal‐3 and MMP2/9 were downregulated in runx2‐silenced cell lines. In this investigation, we revealed that regulation of gal‐3 expression was strongly correlated with runx2 transcription factor in human thyroid carcinoma. Considering the contribution of human gal‐3 in collaboration with MMP2/9 to the malignant characters of many cancers, regulation of their expressions through runx2 seems like one of the key regulatory mechanism for malignant potential of human thyroid carcinoma. Accordingly, runx2 transcription factor inhibitors can be a potential target in order to prevent gal‐3 mediated malignancy of human thyroid carcinoma. J. Cell. Biochem. 118: 3911–3919, 2017. © 2017 Wiley Periodicals, Inc.
Gal‐3 is one of the important contributor of malignancy. In this investigation, we revealed that regulation of gal‐3 expression was strongly correlated with runx2 transcription factor in human thyroid carcinoma.</description><identifier>ISSN: 0730-2312</identifier><identifier>EISSN: 1097-4644</identifier><identifier>DOI: 10.1002/jcb.26043</identifier><identifier>PMID: 28390192</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Biotechnology ; Carcinoma, Papillary - genetics ; Carcinoma, Papillary - metabolism ; Carcinoma, Papillary - pathology ; Cbfa-1 protein ; Cell Line, Tumor ; Core Binding Factor Alpha 1 Subunit - genetics ; Core Binding Factor Alpha 1 Subunit - metabolism ; Down-Regulation ; Fluorescence ; Galectin 3 - biosynthesis ; Galectin 3 - genetics ; Galectin-3 ; Gelatinase A ; Gene expression ; Gene Expression Regulation, Neoplastic ; Gene regulation ; Humans ; Malignancy ; Metastases ; Microscopy ; MMP‐2 ; MMP‐9 ; Neoplasm Proteins - genetics ; Neoplasm Proteins - metabolism ; Regulatory mechanisms (biology) ; Runx2 ; siRNA ; Thyroid ; Thyroid cancer ; Thyroid Cancer, Papillary ; THYROID CARCINOMA ; Thyroid Neoplasms - genetics ; Thyroid Neoplasms - metabolism ; Thyroid Neoplasms - pathology ; Transcription factors ; Transfection ; Transformed cells ; Tumor cell lines ; Western blotting</subject><ispartof>Journal of cellular biochemistry, 2017-11, Vol.118 (11), p.3911-3919</ispartof><rights>2017 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3533-9367c22d5bd9e685083e53afcfe7de5c892b019086d282b4f29a3fdbd947343</citedby><cites>FETCH-LOGICAL-c3533-9367c22d5bd9e685083e53afcfe7de5c892b019086d282b4f29a3fdbd947343</cites><orcidid>0000-0003-0866-8796</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjcb.26043$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjcb.26043$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28390192$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kaptan, Engin</creatorcontrib><creatorcontrib>Sancar Bas, Serap</creatorcontrib><creatorcontrib>Sancakli, Aylin</creatorcontrib><creatorcontrib>Aktas, Hatice Gumushan</creatorcontrib><creatorcontrib>Bayrak, Bertan Boran</creatorcontrib><creatorcontrib>Yanardag, Refiye</creatorcontrib><creatorcontrib>Bolkent, Sehnaz</creatorcontrib><title>Runt‐Related Transcription Factor 2 (Runx2) Is Responsible for Galectin‐3 Overexpression in Human Thyroid Carcinoma</title><title>Journal of cellular biochemistry</title><addtitle>J Cell Biochem</addtitle><description>ABSTRACT
Runx2 promotes metastatic ability of cancer cells by directly activating some of the mediators regarding malignancy. Galectin‐3 (Gal‐3) extensively expressed in normal and transformed cells and it is responsible for many cellular processes. In this study, we aimed to investigate whether there is any relationship between runx2 transcription factor and regulation of galectin‐3 expression in different human thyroid carcinoma cell lines. To show effects of runx2 transcription factor on gal‐3 expression, we developed runx2 knockdown model in the thyroid carcinoma cell lines; anaplastic 8505C and 8305C and, papillary TPC‐1 and follicular FTC‐133 by using siRNA transfection. We analyzed the protein expressions and mRNA levels of gal‐3 and MMP2/9 in the runx2‐silenced cell lines using Western blotting, qPCR, and fluorescent microscopy. Our results showed that mRNA expression levels of gal‐3 and MMP2/9 were downregulated in runx2‐silenced cell lines. In this investigation, we revealed that regulation of gal‐3 expression was strongly correlated with runx2 transcription factor in human thyroid carcinoma. Considering the contribution of human gal‐3 in collaboration with MMP2/9 to the malignant characters of many cancers, regulation of their expressions through runx2 seems like one of the key regulatory mechanism for malignant potential of human thyroid carcinoma. Accordingly, runx2 transcription factor inhibitors can be a potential target in order to prevent gal‐3 mediated malignancy of human thyroid carcinoma. J. Cell. Biochem. 118: 3911–3919, 2017. © 2017 Wiley Periodicals, Inc.
Gal‐3 is one of the important contributor of malignancy. In this investigation, we revealed that regulation of gal‐3 expression was strongly correlated with runx2 transcription factor in human thyroid carcinoma.</description><subject>Biotechnology</subject><subject>Carcinoma, Papillary - genetics</subject><subject>Carcinoma, Papillary - metabolism</subject><subject>Carcinoma, Papillary - pathology</subject><subject>Cbfa-1 protein</subject><subject>Cell Line, Tumor</subject><subject>Core Binding Factor Alpha 1 Subunit - genetics</subject><subject>Core Binding Factor Alpha 1 Subunit - metabolism</subject><subject>Down-Regulation</subject><subject>Fluorescence</subject><subject>Galectin 3 - biosynthesis</subject><subject>Galectin 3 - genetics</subject><subject>Galectin-3</subject><subject>Gelatinase A</subject><subject>Gene expression</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Gene regulation</subject><subject>Humans</subject><subject>Malignancy</subject><subject>Metastases</subject><subject>Microscopy</subject><subject>MMP‐2</subject><subject>MMP‐9</subject><subject>Neoplasm Proteins - genetics</subject><subject>Neoplasm Proteins - metabolism</subject><subject>Regulatory mechanisms (biology)</subject><subject>Runx2</subject><subject>siRNA</subject><subject>Thyroid</subject><subject>Thyroid cancer</subject><subject>Thyroid Cancer, Papillary</subject><subject>THYROID CARCINOMA</subject><subject>Thyroid Neoplasms - genetics</subject><subject>Thyroid Neoplasms - metabolism</subject><subject>Thyroid Neoplasms - pathology</subject><subject>Transcription factors</subject><subject>Transfection</subject><subject>Transformed cells</subject><subject>Tumor cell lines</subject><subject>Western blotting</subject><issn>0730-2312</issn><issn>1097-4644</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kb9u2zAQh4kiReO4HfoCAYEsziCbIvWHHFsjiVMECOB6JyjqhNCQSJWU4njrI-QZ8ySl67RDgEw33Hcf7u6H0NeUzFNC6GKrqzktSMY-oElKRJlkRZadoAkpGUkoS-kpOgthSwgRgtFP6JRyJkgq6ATt1qMdXn4_r6FVA9R445UN2pt-MM7ia6UH5zHFs4g90Ut8G_AaQu9sMFULuInNG9WCHoyNEobvH8HDU-8hhMO8sXg1dsrizcPeO1PjpfLaWNepz-hjo9oAX17rFP28vtosV8nd_c3t8ttdolnOWCJYUWpK67yqBRQ8J5xBzlSjGyhryDUXtIqHEF7UlNMqa6hQrKkjnZUsY1M0O1p7736NEAbZmaChbZUFNwaZcp6LnBS8iOjFG3TrRm_jbjIVTHCSi_jOKbo8Utq7EDw0svemU34vUyIPWciYhfybRWTPX41j1UH9n_z3_AgsjsDOtLB_3yR_LL8flX8A31yUJw</recordid><startdate>201711</startdate><enddate>201711</enddate><creator>Kaptan, Engin</creator><creator>Sancar Bas, Serap</creator><creator>Sancakli, Aylin</creator><creator>Aktas, Hatice Gumushan</creator><creator>Bayrak, Bertan Boran</creator><creator>Yanardag, Refiye</creator><creator>Bolkent, Sehnaz</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7T7</scope><scope>7TK</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-0866-8796</orcidid></search><sort><creationdate>201711</creationdate><title>Runt‐Related Transcription Factor 2 (Runx2) Is Responsible for Galectin‐3 Overexpression in Human Thyroid Carcinoma</title><author>Kaptan, Engin ; 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Runx2 promotes metastatic ability of cancer cells by directly activating some of the mediators regarding malignancy. Galectin‐3 (Gal‐3) extensively expressed in normal and transformed cells and it is responsible for many cellular processes. In this study, we aimed to investigate whether there is any relationship between runx2 transcription factor and regulation of galectin‐3 expression in different human thyroid carcinoma cell lines. To show effects of runx2 transcription factor on gal‐3 expression, we developed runx2 knockdown model in the thyroid carcinoma cell lines; anaplastic 8505C and 8305C and, papillary TPC‐1 and follicular FTC‐133 by using siRNA transfection. We analyzed the protein expressions and mRNA levels of gal‐3 and MMP2/9 in the runx2‐silenced cell lines using Western blotting, qPCR, and fluorescent microscopy. Our results showed that mRNA expression levels of gal‐3 and MMP2/9 were downregulated in runx2‐silenced cell lines. In this investigation, we revealed that regulation of gal‐3 expression was strongly correlated with runx2 transcription factor in human thyroid carcinoma. Considering the contribution of human gal‐3 in collaboration with MMP2/9 to the malignant characters of many cancers, regulation of their expressions through runx2 seems like one of the key regulatory mechanism for malignant potential of human thyroid carcinoma. Accordingly, runx2 transcription factor inhibitors can be a potential target in order to prevent gal‐3 mediated malignancy of human thyroid carcinoma. J. Cell. Biochem. 118: 3911–3919, 2017. © 2017 Wiley Periodicals, Inc.
Gal‐3 is one of the important contributor of malignancy. In this investigation, we revealed that regulation of gal‐3 expression was strongly correlated with runx2 transcription factor in human thyroid carcinoma.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>28390192</pmid><doi>10.1002/jcb.26043</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0003-0866-8796</orcidid></addata></record> |
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| subjects | Biotechnology Carcinoma, Papillary - genetics Carcinoma, Papillary - metabolism Carcinoma, Papillary - pathology Cbfa-1 protein Cell Line, Tumor Core Binding Factor Alpha 1 Subunit - genetics Core Binding Factor Alpha 1 Subunit - metabolism Down-Regulation Fluorescence Galectin 3 - biosynthesis Galectin 3 - genetics Galectin-3 Gelatinase A Gene expression Gene Expression Regulation, Neoplastic Gene regulation Humans Malignancy Metastases Microscopy MMP‐2 MMP‐9 Neoplasm Proteins - genetics Neoplasm Proteins - metabolism Regulatory mechanisms (biology) Runx2 siRNA Thyroid Thyroid cancer Thyroid Cancer, Papillary THYROID CARCINOMA Thyroid Neoplasms - genetics Thyroid Neoplasms - metabolism Thyroid Neoplasms - pathology Transcription factors Transfection Transformed cells Tumor cell lines Western blotting |
| title | Runt‐Related Transcription Factor 2 (Runx2) Is Responsible for Galectin‐3 Overexpression in Human Thyroid Carcinoma |
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