Wip1: A candidate phosphatase for cancer diagnosis and treatment
•Investigation about the role of Wip1 phosphatase in cancer.•Alteration in cancer treatment responses by modifying phosphorylation procedures.•Study about the role of Wip1 as a new candidate for cancer diagnosis and prognosis. The critical regulatory mechanisms in numerous cellular pathways includin...
Gespeichert in:
| Veröffentlicht in: | DNA repair 2017-06, Vol.54, p.63-66 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 66 |
|---|---|
| container_issue | |
| container_start_page | 63 |
| container_title | DNA repair |
| container_volume | 54 |
| creator | Oghabi Bakhshaiesh, Tayebeh Majidzadeh-A, Keivan Esmaeili, Rezvan |
| description | •Investigation about the role of Wip1 phosphatase in cancer.•Alteration in cancer treatment responses by modifying phosphorylation procedures.•Study about the role of Wip1 as a new candidate for cancer diagnosis and prognosis.
The critical regulatory mechanisms in numerous cellular pathways including cell survival and DNA damage response mostly depend on phosphorylation and dephosphorylation of proteins. The serine/threonine phosphatase wild-type p53-induced phosphatase 1 (Wip1) is a growth-promoting phosphatase and its numerous downstream targets are important tumor suppressors. Here, we review the Wip1 activity and its relevance to cancer as an oncoprotein. Consecutive investigations about Wip1 and its relation to cancer is critical, as these studies ultimately contribute to the etiology of cancer. A number of innovative studies have recently investigated the importance of Wip1 as a new candidate for cancer diagnosis and prognosis. Accordingly, we discuss the present challenges of using Wip1 as a target for cancer treatment. |
| doi_str_mv | 10.1016/j.dnarep.2017.03.004 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1885948819</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S156878641730071X</els_id><sourcerecordid>1885948819</sourcerecordid><originalsourceid>FETCH-LOGICAL-c428t-d31bb0817ec4fef4920bc878ea23e20eecd290dcbd9f83b0c37510a19b3b139a3</originalsourceid><addsrcrecordid>eNp9kE1LAzEQhoMotlb_gcgeveyabLK7iQexFL-g4EXxGPIxa1O6Hyap4L93y9YePc3APO8M8yB0SXBGMClv1pltlYc-yzGpMkwzjNkRmpKi5GnFi_L40Jdsgs5CWGNMiqosT9Ek55QXrBBTdP_henKbzBOjWuusipD0qy70KxVVgKTu_G5iwCfWqc-2Cy4kA5lEDyo20MZzdFKrTYCLfZ2h98eHt8Vzunx9elnMl6lhOY-ppURrzEkFhtVQM5FjbXjFQeUUcgxgbC6wNdqKmlONDa0KghURmmpChaIzdD3u7X33tYUQZeOCgc1GtdBtgyScF4JxTsSAshE1vgvBQy177xrlfyTBcudOruXoTu7cSUzl4G6IXe0vbHUD9hD6kzUAdyMAw5_fDrwMxsEgxzoPJkrbuf8v_AK1pIGa</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1885948819</pqid></control><display><type>article</type><title>Wip1: A candidate phosphatase for cancer diagnosis and treatment</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><creator>Oghabi Bakhshaiesh, Tayebeh ; Majidzadeh-A, Keivan ; Esmaeili, Rezvan</creator><creatorcontrib>Oghabi Bakhshaiesh, Tayebeh ; Majidzadeh-A, Keivan ; Esmaeili, Rezvan</creatorcontrib><description>•Investigation about the role of Wip1 phosphatase in cancer.•Alteration in cancer treatment responses by modifying phosphorylation procedures.•Study about the role of Wip1 as a new candidate for cancer diagnosis and prognosis.
The critical regulatory mechanisms in numerous cellular pathways including cell survival and DNA damage response mostly depend on phosphorylation and dephosphorylation of proteins. The serine/threonine phosphatase wild-type p53-induced phosphatase 1 (Wip1) is a growth-promoting phosphatase and its numerous downstream targets are important tumor suppressors. Here, we review the Wip1 activity and its relevance to cancer as an oncoprotein. Consecutive investigations about Wip1 and its relation to cancer is critical, as these studies ultimately contribute to the etiology of cancer. A number of innovative studies have recently investigated the importance of Wip1 as a new candidate for cancer diagnosis and prognosis. Accordingly, we discuss the present challenges of using Wip1 as a target for cancer treatment.</description><identifier>ISSN: 1568-7864</identifier><identifier>EISSN: 1568-7856</identifier><identifier>DOI: 10.1016/j.dnarep.2017.03.004</identifier><identifier>PMID: 28385459</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Cancer therapy ; DNA Damage ; DNA damage response ; Humans ; Neoplasms - diagnosis ; Neoplasms - drug therapy ; Neoplasms - metabolism ; Oncogene Proteins ; p53 ; PPM1D ; Protein Phosphatase 2C ; Wip1</subject><ispartof>DNA repair, 2017-06, Vol.54, p.63-66</ispartof><rights>2017 Elsevier B.V.</rights><rights>Copyright © 2017 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c428t-d31bb0817ec4fef4920bc878ea23e20eecd290dcbd9f83b0c37510a19b3b139a3</citedby><cites>FETCH-LOGICAL-c428t-d31bb0817ec4fef4920bc878ea23e20eecd290dcbd9f83b0c37510a19b3b139a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.dnarep.2017.03.004$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27929,27930,46000</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28385459$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Oghabi Bakhshaiesh, Tayebeh</creatorcontrib><creatorcontrib>Majidzadeh-A, Keivan</creatorcontrib><creatorcontrib>Esmaeili, Rezvan</creatorcontrib><title>Wip1: A candidate phosphatase for cancer diagnosis and treatment</title><title>DNA repair</title><addtitle>DNA Repair (Amst)</addtitle><description>•Investigation about the role of Wip1 phosphatase in cancer.•Alteration in cancer treatment responses by modifying phosphorylation procedures.•Study about the role of Wip1 as a new candidate for cancer diagnosis and prognosis.
The critical regulatory mechanisms in numerous cellular pathways including cell survival and DNA damage response mostly depend on phosphorylation and dephosphorylation of proteins. The serine/threonine phosphatase wild-type p53-induced phosphatase 1 (Wip1) is a growth-promoting phosphatase and its numerous downstream targets are important tumor suppressors. Here, we review the Wip1 activity and its relevance to cancer as an oncoprotein. Consecutive investigations about Wip1 and its relation to cancer is critical, as these studies ultimately contribute to the etiology of cancer. A number of innovative studies have recently investigated the importance of Wip1 as a new candidate for cancer diagnosis and prognosis. Accordingly, we discuss the present challenges of using Wip1 as a target for cancer treatment.</description><subject>Cancer therapy</subject><subject>DNA Damage</subject><subject>DNA damage response</subject><subject>Humans</subject><subject>Neoplasms - diagnosis</subject><subject>Neoplasms - drug therapy</subject><subject>Neoplasms - metabolism</subject><subject>Oncogene Proteins</subject><subject>p53</subject><subject>PPM1D</subject><subject>Protein Phosphatase 2C</subject><subject>Wip1</subject><issn>1568-7864</issn><issn>1568-7856</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LAzEQhoMotlb_gcgeveyabLK7iQexFL-g4EXxGPIxa1O6Hyap4L93y9YePc3APO8M8yB0SXBGMClv1pltlYc-yzGpMkwzjNkRmpKi5GnFi_L40Jdsgs5CWGNMiqosT9Ek55QXrBBTdP_henKbzBOjWuusipD0qy70KxVVgKTu_G5iwCfWqc-2Cy4kA5lEDyo20MZzdFKrTYCLfZ2h98eHt8Vzunx9elnMl6lhOY-ppURrzEkFhtVQM5FjbXjFQeUUcgxgbC6wNdqKmlONDa0KghURmmpChaIzdD3u7X33tYUQZeOCgc1GtdBtgyScF4JxTsSAshE1vgvBQy177xrlfyTBcudOruXoTu7cSUzl4G6IXe0vbHUD9hD6kzUAdyMAw5_fDrwMxsEgxzoPJkrbuf8v_AK1pIGa</recordid><startdate>201706</startdate><enddate>201706</enddate><creator>Oghabi Bakhshaiesh, Tayebeh</creator><creator>Majidzadeh-A, Keivan</creator><creator>Esmaeili, Rezvan</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201706</creationdate><title>Wip1: A candidate phosphatase for cancer diagnosis and treatment</title><author>Oghabi Bakhshaiesh, Tayebeh ; Majidzadeh-A, Keivan ; Esmaeili, Rezvan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c428t-d31bb0817ec4fef4920bc878ea23e20eecd290dcbd9f83b0c37510a19b3b139a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Cancer therapy</topic><topic>DNA Damage</topic><topic>DNA damage response</topic><topic>Humans</topic><topic>Neoplasms - diagnosis</topic><topic>Neoplasms - drug therapy</topic><topic>Neoplasms - metabolism</topic><topic>Oncogene Proteins</topic><topic>p53</topic><topic>PPM1D</topic><topic>Protein Phosphatase 2C</topic><topic>Wip1</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Oghabi Bakhshaiesh, Tayebeh</creatorcontrib><creatorcontrib>Majidzadeh-A, Keivan</creatorcontrib><creatorcontrib>Esmaeili, Rezvan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>DNA repair</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Oghabi Bakhshaiesh, Tayebeh</au><au>Majidzadeh-A, Keivan</au><au>Esmaeili, Rezvan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Wip1: A candidate phosphatase for cancer diagnosis and treatment</atitle><jtitle>DNA repair</jtitle><addtitle>DNA Repair (Amst)</addtitle><date>2017-06</date><risdate>2017</risdate><volume>54</volume><spage>63</spage><epage>66</epage><pages>63-66</pages><issn>1568-7864</issn><eissn>1568-7856</eissn><abstract>•Investigation about the role of Wip1 phosphatase in cancer.•Alteration in cancer treatment responses by modifying phosphorylation procedures.•Study about the role of Wip1 as a new candidate for cancer diagnosis and prognosis.
The critical regulatory mechanisms in numerous cellular pathways including cell survival and DNA damage response mostly depend on phosphorylation and dephosphorylation of proteins. The serine/threonine phosphatase wild-type p53-induced phosphatase 1 (Wip1) is a growth-promoting phosphatase and its numerous downstream targets are important tumor suppressors. Here, we review the Wip1 activity and its relevance to cancer as an oncoprotein. Consecutive investigations about Wip1 and its relation to cancer is critical, as these studies ultimately contribute to the etiology of cancer. A number of innovative studies have recently investigated the importance of Wip1 as a new candidate for cancer diagnosis and prognosis. Accordingly, we discuss the present challenges of using Wip1 as a target for cancer treatment.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>28385459</pmid><doi>10.1016/j.dnarep.2017.03.004</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1568-7864 |
| ispartof | DNA repair, 2017-06, Vol.54, p.63-66 |
| issn | 1568-7864 1568-7856 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1885948819 |
| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Cancer therapy DNA Damage DNA damage response Humans Neoplasms - diagnosis Neoplasms - drug therapy Neoplasms - metabolism Oncogene Proteins p53 PPM1D Protein Phosphatase 2C Wip1 |
| title | Wip1: A candidate phosphatase for cancer diagnosis and treatment |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-16T05%3A39%3A55IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Wip1:%20A%20candidate%20phosphatase%20for%20cancer%20diagnosis%20and%20treatment&rft.jtitle=DNA%20repair&rft.au=Oghabi%20Bakhshaiesh,%20Tayebeh&rft.date=2017-06&rft.volume=54&rft.spage=63&rft.epage=66&rft.pages=63-66&rft.issn=1568-7864&rft.eissn=1568-7856&rft_id=info:doi/10.1016/j.dnarep.2017.03.004&rft_dat=%3Cproquest_cross%3E1885948819%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1885948819&rft_id=info:pmid/28385459&rft_els_id=S156878641730071X&rfr_iscdi=true |