An Exome-Chip Association Analysis in Chinese Subjects Reveals a Functional Missense Variant of GCKR That Regulates FGF21 Levels

Fibroblast growth factor 21 (FGF21) is increasingly recognized as an important metabolic regulator of glucose homeostasis. Here, we conducted an exome-chip association analysis by genotyping 5,169 Chinese individuals from a community-based cohort and two clinic-based cohorts. A custom Asian exome-ch...

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Veröffentlicht in:	Diabetes (New York, N.Y.) N.Y.), 2017-06, Vol.66 (6), p.1723-1728
Hauptverfasser:	Cheung, Chloe Y Y, Tang, Clara S, Xu, Aimin, Lee, Chi-Ho, Au, Ka-Wing, Xu, Lin, Fong, Carol H Y, Kwok, Kelvin H M, Chow, Wing-Sun, Woo, Yu-Cho, Yuen, Michele M A, Cherny, Stacey S, Hai, JoJo, Cheung, Bernard M Y, Tan, Kathryn C B, Lam, Tai-Hing, Tse, Hung-Fat, Sham, Pak-Chung, Lam, Karen S L
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - genetics Adult Aged Asian Continental Ancestry Group - genetics Asian people Association analysis Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - metabolism Carnitine Carnitine O-Palmitoyltransferase Exome Fatty Acids - biosynthesis Female Fibroblast growth factors Fibroblast Growth Factors - genetics Gene expression Gene Expression Regulation - genetics Genomes Genotyping Glucokinase Glucokinase - metabolism Glucose Glucose-6-Phosphate - metabolism Homeostasis Humans Kinases Male Malonyl Coenzyme A - metabolism Middle Aged Mutation, Missense Polymorphism Polymorphism, Single Nucleotide Single-nucleotide polymorphism
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