Aerobic Exercise Decreases Lung Inflammation by IgE Decrement in an OVA Mice Model
Abstract Aerobic exercise (AE) reduces lung function decline and risk of exacerbations in asthmatic patients. However, the inflammatory lung response involved in exercise during the sensitization remains unclear. Therefore, we evaluated the effects of exercise for 2 weeks in an experimental model of...
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| Veröffentlicht in: | International journal of sports medicine 2017-06, Vol.38 (6), p.473-480 |
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| creator | Camargo Hizume-Kunzler, Deborah Greiffo, Flavia R. Fortkamp, Bárbara Ribeiro Freitas, Gabriel Keller Nascimento, Juliana Regina Bruggemann, Thayse Melo Avila, Leonardo Perini, Adenir Bobinski, Franciane Duarte Silva, Morgana Rocha Lapa, Fernanda Paula Vieira, Rodolfo Vargas Horewicz, Verônica Soares dos Santos, Adair Roberto Cattelan Bonorino, Kelly |
| description | Abstract
Aerobic exercise (AE) reduces lung function decline and risk of exacerbations in asthmatic patients. However, the inflammatory lung response involved in exercise during the sensitization remains unclear. Therefore, we evaluated the effects of exercise for 2 weeks in an experimental model of sensitization and single ovalbumin-challenge. Mice were divided into 4 groups: mice non-sensitized and not submitted to exercise (Sedentary, n=10); mice non-sensitized and submitted to exercise (Exercise, n=10); mice sensitized and exposed to ovalbumin (OVA, n=10); and mice sensitized, submitted to exercise and exposed to OVA (OVA+Exercise, n=10). 24 h after the OVA/saline exposure, we counted inflammatory cells from bronchoalveolar fluid (BALF), lung levels of total IgE, IL-4, IL-5, IL-10 and IL-1ra, measurements of OVA-specific IgG1 and IgE, and VEGF and NOS-2 expression via western blotting. AE reduced cell counts from BALF in the OVA group (p |
| doi_str_mv | 10.1055/s-0042-121638 |
| format | Article |
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Aerobic exercise (AE) reduces lung function decline and risk of exacerbations in asthmatic patients. However, the inflammatory lung response involved in exercise during the sensitization remains unclear. Therefore, we evaluated the effects of exercise for 2 weeks in an experimental model of sensitization and single ovalbumin-challenge. Mice were divided into 4 groups: mice non-sensitized and not submitted to exercise (Sedentary, n=10); mice non-sensitized and submitted to exercise (Exercise, n=10); mice sensitized and exposed to ovalbumin (OVA, n=10); and mice sensitized, submitted to exercise and exposed to OVA (OVA+Exercise, n=10). 24 h after the OVA/saline exposure, we counted inflammatory cells from bronchoalveolar fluid (BALF), lung levels of total IgE, IL-4, IL-5, IL-10 and IL-1ra, measurements of OVA-specific IgG1 and IgE, and VEGF and NOS-2 expression via western blotting. AE reduced cell counts from BALF in the OVA group (p<0.05), total IgE, IL-4 and IL-5 lung levels and OVA-specific IgE and IgG1 titers (p<0.05). There was an increase of NOS-2 expression, IL-10 and IL-1ra lung levels in the OVA groups (p<0.05). Our results showed that AE attenuated the acute lung inflammation, suggesting immunomodulatory properties on the sensitization process in the early phases of antigen presentation in asthma.</description><identifier>ISSN: 0172-4622</identifier><identifier>EISSN: 1439-3964</identifier><identifier>DOI: 10.1055/s-0042-121638</identifier><identifier>PMID: 28388779</identifier><language>eng</language><publisher>Stuttgart · New York: Georg Thieme Verlag KG</publisher><subject>Aerobics ; Animals ; Asthma - immunology ; Asthma - therapy ; Bronchoalveolar Lavage Fluid - cytology ; Exercise ; Immunoglobulin E - immunology ; Immunoglobulin G - immunology ; Immunology ; Interleukins - immunology ; Male ; Mice ; Nitric Oxide Synthase Type II - metabolism ; Ovalbumin ; Physical Conditioning, Animal ; Physical fitness ; Pneumonia - immunology ; Pneumonia - therapy ; Vascular Endothelial Growth Factor A - metabolism</subject><ispartof>International journal of sports medicine, 2017-06, Vol.38 (6), p.473-480</ispartof><rights>Georg Thieme Verlag KG Stuttgart · New York.</rights><rights>Copyright Georg Thieme Verlag Stuttgart Jun 2017</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c358t-b5eea2e65d6f666423046fe3b121bcdc4d6ae2c38c2da8f68bc968728f91e0863</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0042-121638.pdf$$EPDF$$P50$$Gthieme$$H</linktopdf><linktohtml>$$Uhttps://www.thieme-connect.de/products/ejournals/html/10.1055/s-0042-121638$$EHTML$$P50$$Gthieme$$H</linktohtml><link.rule.ids>314,780,784,3015,3016,27922,27923,54557,54558</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28388779$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Camargo Hizume-Kunzler, Deborah</creatorcontrib><creatorcontrib>Greiffo, Flavia R.</creatorcontrib><creatorcontrib>Fortkamp, Bárbara</creatorcontrib><creatorcontrib>Ribeiro Freitas, Gabriel</creatorcontrib><creatorcontrib>Keller Nascimento, Juliana</creatorcontrib><creatorcontrib>Regina Bruggemann, Thayse</creatorcontrib><creatorcontrib>Melo Avila, Leonardo</creatorcontrib><creatorcontrib>Perini, Adenir</creatorcontrib><creatorcontrib>Bobinski, Franciane</creatorcontrib><creatorcontrib>Duarte Silva, Morgana</creatorcontrib><creatorcontrib>Rocha Lapa, Fernanda</creatorcontrib><creatorcontrib>Paula Vieira, Rodolfo</creatorcontrib><creatorcontrib>Vargas Horewicz, Verônica</creatorcontrib><creatorcontrib>Soares dos Santos, Adair Roberto</creatorcontrib><creatorcontrib>Cattelan Bonorino, Kelly</creatorcontrib><title>Aerobic Exercise Decreases Lung Inflammation by IgE Decrement in an OVA Mice Model</title><title>International journal of sports medicine</title><addtitle>Int J Sports Med</addtitle><description>Abstract
Aerobic exercise (AE) reduces lung function decline and risk of exacerbations in asthmatic patients. However, the inflammatory lung response involved in exercise during the sensitization remains unclear. Therefore, we evaluated the effects of exercise for 2 weeks in an experimental model of sensitization and single ovalbumin-challenge. Mice were divided into 4 groups: mice non-sensitized and not submitted to exercise (Sedentary, n=10); mice non-sensitized and submitted to exercise (Exercise, n=10); mice sensitized and exposed to ovalbumin (OVA, n=10); and mice sensitized, submitted to exercise and exposed to OVA (OVA+Exercise, n=10). 24 h after the OVA/saline exposure, we counted inflammatory cells from bronchoalveolar fluid (BALF), lung levels of total IgE, IL-4, IL-5, IL-10 and IL-1ra, measurements of OVA-specific IgG1 and IgE, and VEGF and NOS-2 expression via western blotting. AE reduced cell counts from BALF in the OVA group (p<0.05), total IgE, IL-4 and IL-5 lung levels and OVA-specific IgE and IgG1 titers (p<0.05). There was an increase of NOS-2 expression, IL-10 and IL-1ra lung levels in the OVA groups (p<0.05). Our results showed that AE attenuated the acute lung inflammation, suggesting immunomodulatory properties on the sensitization process in the early phases of antigen presentation in asthma.</description><subject>Aerobics</subject><subject>Animals</subject><subject>Asthma - immunology</subject><subject>Asthma - therapy</subject><subject>Bronchoalveolar Lavage Fluid - cytology</subject><subject>Exercise</subject><subject>Immunoglobulin E - immunology</subject><subject>Immunoglobulin G - immunology</subject><subject>Immunology</subject><subject>Interleukins - immunology</subject><subject>Male</subject><subject>Mice</subject><subject>Nitric Oxide Synthase Type II - metabolism</subject><subject>Ovalbumin</subject><subject>Physical Conditioning, Animal</subject><subject>Physical fitness</subject><subject>Pneumonia - immunology</subject><subject>Pneumonia - therapy</subject><subject>Vascular Endothelial Growth Factor A - metabolism</subject><issn>0172-4622</issn><issn>1439-3964</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpt0M9LwzAUwPEgis7p0asEvHiwml9N0-OYUwcbA1GvIU1fZ6VNNWnB_fd2dCqIueTy4b3ki9AZJdeUxPFNiAgRLKKMSq720IgKnkY8lWIfjQhNWCQkY0foOIQ3QqhIKT9ER0xxpZIkHaHHCfgmKy2efYK3ZQB8C9aDCRDwonNrPHdFZeratGXjcLbB8_VsIDW4FpcOG4dXLxO8LC3gZZNDdYIOClMFON3dY_R8N3uaPkSL1f18OllElseqjbIYwDCQcS4LKaVgnAhZAM_6r2Q2tyKXBpjlyrLcqEKqzKZSJUwVKQWiJB-jy2Huu28-OgitrstgoaqMg6YLmioVp6I_W3rxh741nXf96zTrq5CYq0T1KhqU9U0IHgr97sva-I2mRG9j66C3sfUQu_fnu6ldVkP-o7_r9uBqAO1r2ff6Xfr_vC8kOoVF</recordid><startdate>201706</startdate><enddate>201706</enddate><creator>Camargo Hizume-Kunzler, Deborah</creator><creator>Greiffo, Flavia R.</creator><creator>Fortkamp, Bárbara</creator><creator>Ribeiro Freitas, Gabriel</creator><creator>Keller Nascimento, Juliana</creator><creator>Regina Bruggemann, Thayse</creator><creator>Melo Avila, Leonardo</creator><creator>Perini, Adenir</creator><creator>Bobinski, Franciane</creator><creator>Duarte Silva, Morgana</creator><creator>Rocha Lapa, Fernanda</creator><creator>Paula Vieira, Rodolfo</creator><creator>Vargas Horewicz, Verônica</creator><creator>Soares dos Santos, Adair Roberto</creator><creator>Cattelan Bonorino, Kelly</creator><general>Georg Thieme Verlag KG</general><general>Georg Thieme Verlag Stuttgart</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TS</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>201706</creationdate><title>Aerobic Exercise Decreases Lung Inflammation by IgE Decrement in an OVA Mice Model</title><author>Camargo Hizume-Kunzler, Deborah ; 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Aerobic exercise (AE) reduces lung function decline and risk of exacerbations in asthmatic patients. However, the inflammatory lung response involved in exercise during the sensitization remains unclear. Therefore, we evaluated the effects of exercise for 2 weeks in an experimental model of sensitization and single ovalbumin-challenge. Mice were divided into 4 groups: mice non-sensitized and not submitted to exercise (Sedentary, n=10); mice non-sensitized and submitted to exercise (Exercise, n=10); mice sensitized and exposed to ovalbumin (OVA, n=10); and mice sensitized, submitted to exercise and exposed to OVA (OVA+Exercise, n=10). 24 h after the OVA/saline exposure, we counted inflammatory cells from bronchoalveolar fluid (BALF), lung levels of total IgE, IL-4, IL-5, IL-10 and IL-1ra, measurements of OVA-specific IgG1 and IgE, and VEGF and NOS-2 expression via western blotting. AE reduced cell counts from BALF in the OVA group (p<0.05), total IgE, IL-4 and IL-5 lung levels and OVA-specific IgE and IgG1 titers (p<0.05). There was an increase of NOS-2 expression, IL-10 and IL-1ra lung levels in the OVA groups (p<0.05). Our results showed that AE attenuated the acute lung inflammation, suggesting immunomodulatory properties on the sensitization process in the early phases of antigen presentation in asthma.</abstract><cop>Stuttgart · New York</cop><pub>Georg Thieme Verlag KG</pub><pmid>28388779</pmid><doi>10.1055/s-0042-121638</doi><tpages>8</tpages></addata></record> |
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| subjects | Aerobics Animals Asthma - immunology Asthma - therapy Bronchoalveolar Lavage Fluid - cytology Exercise Immunoglobulin E - immunology Immunoglobulin G - immunology Immunology Interleukins - immunology Male Mice Nitric Oxide Synthase Type II - metabolism Ovalbumin Physical Conditioning, Animal Physical fitness Pneumonia - immunology Pneumonia - therapy Vascular Endothelial Growth Factor A - metabolism |
| title | Aerobic Exercise Decreases Lung Inflammation by IgE Decrement in an OVA Mice Model |
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