Sprouty 2, an Early Response Gene Regulator of FosB and Mesenchymal Stem Cell Proliferation During Mechanical Loading and Osteogenic Differentiation

ABSTRACT Sprouty 2 (Spry2), an inhibitor of MAP kinase signaling was previously shown by our group to be induced during mechanical loading of mesenchymal stem cells (MSCs). Here, we studied the implication of Spry2 activation during mechanical loading and chemically induced MSC differentiation. Spry...

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Veröffentlicht in:	Journal of cellular biochemistry 2017-09, Vol.118 (9), p.2606-2614
Hauptverfasser:	Schneider, A. Kristin, Cama, Giuseppe, Ghuman, Mandeep, Hughes, Francis J., Gharibi, Borzo
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation analysis Biocompatibility Cbfa-1 protein Cell Differentiation Cell Proliferation Core Binding Factor Alpha 1 Subunit - genetics Core Binding Factor Alpha 1 Subunit - metabolism DIFFERENTIATION Differentiation (biology) Enzyme inhibitors Extracellular signal-regulated kinase FosB FosB protein Gene expression Gene Knockdown Techniques Genes Humans Intracellular Signaling Peptides and Proteins - genetics Intracellular Signaling Peptides and Proteins - metabolism Kinases MAP kinase MAP Kinase Signaling System MECHANICAL LOADING Membrane Proteins - genetics Membrane Proteins - metabolism MESENCHYMAL STEM CELL Mesenchymal Stromal Cells - cytology Mesenchymal Stromal Cells - metabolism Mesenchyme Mineralization Mitogen-Activated Protein Kinase 1 - genetics Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 3 - genetics Mitogen-Activated Protein Kinase 3 - metabolism Osteogenesis Phosphorylation Phosphorylation - genetics PROLIFERATION Proto-Oncogene Proteins c-fos - genetics Proto-Oncogene Proteins c-fos - metabolism Sprouty2 Stem cells Stress, Mechanical
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