iNGR-Modified Liposomes for Tumor Vascular Targeting and Tumor Tissue Penetrating Delivery in the Treatment of Glioblastoma

The tumor vascular barrier and tumor stroma barrier become the two main obstacles in the in vivo delivery of nanomedicines. In this study, to overcome the two barriers, we used iNGR, a tumor-penetrating peptide, to modify the liposomes to increase their accumulation and penetration in tumor tissues....

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Veröffentlicht in:	Molecular pharmaceutics 2017-05, Vol.14 (5), p.1811-1820
Hauptverfasser:	Zhou, Jing-e, Yu, Jing, Gao, Lipeng, Sun, Lei, Peng, Ting, Wang, Jing, Zhu, Jianzhong, Lu, Weiyue, Zhang, Lin, Yan, Zhiqiang, Yu, Lei
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotics, Antineoplastic - chemistry Antibiotics, Antineoplastic - therapeutic use Cell Line, Tumor Doxorubicin - chemistry Doxorubicin - therapeutic use Flow Cytometry Fluorescent Antibody Technique Glioblastoma - drug therapy Human Umbilical Vein Endothelial Cells Humans Liposomes - chemistry Microscopy, Electron, Transmission Oligopeptides - chemistry
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