Effects of Mediterranean diet on sexual function in people with newly-diagnosed type 2 diabetes: The MÈDITA trial
Abstract Aims To assess the long-term effect of Mediterranean diet, as compared with low-fat diet, on sexual function in patients with newly-diagnosed type 2 diabetes. Methods In a randomized clinical trial, with a total follow-up of 8.1 years, 215 men and women with newly diagnosed type 2 diabetes...
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| Veröffentlicht in: | Journal of diabetes and its complications 2016-11, Vol.30 (8), p.1519-1524 |
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| creator | Maiorino, Maria Ida Bellastella, Giuseppe Caputo, Mariangela Castaldo, Filomena Improta, Maria Rosaria Giugliano, Dario Esposito, Katherine |
| description | Abstract Aims To assess the long-term effect of Mediterranean diet, as compared with low-fat diet, on sexual function in patients with newly-diagnosed type 2 diabetes. Methods In a randomized clinical trial, with a total follow-up of 8.1 years, 215 men and women with newly diagnosed type 2 diabetes were assigned to Mediterranean diet (n = 108) or a low-fat diet (n = 107).The primary outcome measures were changes of erectile function (IIEF) in diabetic men and of female sexual function (FSFI) in diabetic women. Results There was no difference in baseline sexual function in men (n = 54 vs 52) or women (n = 54 vs 55) randomized to Mediterranean diet or low-fat diet, respectively (P = 0.287, P = 0.815). Over the entire follow-up, the changes of the primary outcomes were significantly lower in the Mediterranean diet group compared with the low-fat group: IIEF and FSFI showed a significantly lesser decrease (1.22 and 1.18, respectively, P = 0.024 and 0.019) with the Mediterranean diet. Baseline C-reactive protein levels predicted ED in men, but not FSD in women. Conclusions Among persons with newly diagnosed type 2 diabetes, a Mediterranean diet reduced the deterioration of sexual function over time in both sexes. |
| doi_str_mv | 10.1016/j.jdiacomp.2016.08.007 |
| format | Article |
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Methods In a randomized clinical trial, with a total follow-up of 8.1 years, 215 men and women with newly diagnosed type 2 diabetes were assigned to Mediterranean diet (n = 108) or a low-fat diet (n = 107).The primary outcome measures were changes of erectile function (IIEF) in diabetic men and of female sexual function (FSFI) in diabetic women. Results There was no difference in baseline sexual function in men (n = 54 vs 52) or women (n = 54 vs 55) randomized to Mediterranean diet or low-fat diet, respectively (P = 0.287, P = 0.815). Over the entire follow-up, the changes of the primary outcomes were significantly lower in the Mediterranean diet group compared with the low-fat group: IIEF and FSFI showed a significantly lesser decrease (1.22 and 1.18, respectively, P = 0.024 and 0.019) with the Mediterranean diet. Baseline C-reactive protein levels predicted ED in men, but not FSD in women. Conclusions Among persons with newly diagnosed type 2 diabetes, a Mediterranean diet reduced the deterioration of sexual function over time in both sexes.</description><identifier>ISSN: 1056-8727</identifier><identifier>EISSN: 1873-460X</identifier><identifier>DOI: 10.1016/j.jdiacomp.2016.08.007</identifier><identifier>PMID: 27614727</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adult ; Alcohol ; C-Reactive Protein - analysis ; Carbohydrates ; Cardiovascular disease ; Diabetes ; Diabetes Mellitus, Type 2 - complications ; Diabetes Mellitus, Type 2 - physiopathology ; Diet ; Diet, Fat-Restricted ; Diet, Mediterranean ; Endocrinology & Metabolism ; Erectile Dysfunction - complications ; Fatty acids ; Female ; Female sexual dysfunction ; Health risk assessment ; Humans ; Legumes ; Lipids ; Male ; Mediterranean diet ; Middle Aged ; Proteins ; Randomized controlled trial ; Sexual Dysfunction, Physiological - complications ; Type 2 diabetes ; Women</subject><ispartof>Journal of diabetes and its complications, 2016-11, Vol.30 (8), p.1519-1524</ispartof><rights>2016 Elsevier Inc.</rights><rights>Copyright © 2016 Elsevier Inc. All rights reserved.</rights><rights>Copyright Elsevier Limited Nov 01, 2016</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c517t-2b8e78ffb38b658fa32598347f4f622d9a1605bc09e63f81d374fa723f8326e13</citedby><cites>FETCH-LOGICAL-c517t-2b8e78ffb38b658fa32598347f4f622d9a1605bc09e63f81d374fa723f8326e13</cites><orcidid>0000-0003-4659-7546</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/1877791566?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976,64364,64366,64368,72218</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27614727$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Maiorino, Maria Ida</creatorcontrib><creatorcontrib>Bellastella, Giuseppe</creatorcontrib><creatorcontrib>Caputo, Mariangela</creatorcontrib><creatorcontrib>Castaldo, Filomena</creatorcontrib><creatorcontrib>Improta, Maria Rosaria</creatorcontrib><creatorcontrib>Giugliano, Dario</creatorcontrib><creatorcontrib>Esposito, Katherine</creatorcontrib><title>Effects of Mediterranean diet on sexual function in people with newly-diagnosed type 2 diabetes: The MÈDITA trial</title><title>Journal of diabetes and its complications</title><addtitle>J Diabetes Complications</addtitle><description>Abstract Aims To assess the long-term effect of Mediterranean diet, as compared with low-fat diet, on sexual function in patients with newly-diagnosed type 2 diabetes. Methods In a randomized clinical trial, with a total follow-up of 8.1 years, 215 men and women with newly diagnosed type 2 diabetes were assigned to Mediterranean diet (n = 108) or a low-fat diet (n = 107).The primary outcome measures were changes of erectile function (IIEF) in diabetic men and of female sexual function (FSFI) in diabetic women. Results There was no difference in baseline sexual function in men (n = 54 vs 52) or women (n = 54 vs 55) randomized to Mediterranean diet or low-fat diet, respectively (P = 0.287, P = 0.815). Over the entire follow-up, the changes of the primary outcomes were significantly lower in the Mediterranean diet group compared with the low-fat group: IIEF and FSFI showed a significantly lesser decrease (1.22 and 1.18, respectively, P = 0.024 and 0.019) with the Mediterranean diet. Baseline C-reactive protein levels predicted ED in men, but not FSD in women. Conclusions Among persons with newly diagnosed type 2 diabetes, a Mediterranean diet reduced the deterioration of sexual function over time in both sexes.</description><subject>Adult</subject><subject>Alcohol</subject><subject>C-Reactive Protein - analysis</subject><subject>Carbohydrates</subject><subject>Cardiovascular disease</subject><subject>Diabetes</subject><subject>Diabetes Mellitus, Type 2 - complications</subject><subject>Diabetes Mellitus, Type 2 - physiopathology</subject><subject>Diet</subject><subject>Diet, Fat-Restricted</subject><subject>Diet, Mediterranean</subject><subject>Endocrinology & Metabolism</subject><subject>Erectile Dysfunction - complications</subject><subject>Fatty acids</subject><subject>Female</subject><subject>Female sexual dysfunction</subject><subject>Health risk assessment</subject><subject>Humans</subject><subject>Legumes</subject><subject>Lipids</subject><subject>Male</subject><subject>Mediterranean diet</subject><subject>Middle Aged</subject><subject>Proteins</subject><subject>Randomized controlled trial</subject><subject>Sexual Dysfunction, Physiological - 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analysis</topic><topic>Carbohydrates</topic><topic>Cardiovascular disease</topic><topic>Diabetes</topic><topic>Diabetes Mellitus, Type 2 - complications</topic><topic>Diabetes Mellitus, Type 2 - physiopathology</topic><topic>Diet</topic><topic>Diet, Fat-Restricted</topic><topic>Diet, Mediterranean</topic><topic>Endocrinology & Metabolism</topic><topic>Erectile Dysfunction - complications</topic><topic>Fatty acids</topic><topic>Female</topic><topic>Female sexual dysfunction</topic><topic>Health risk assessment</topic><topic>Humans</topic><topic>Legumes</topic><topic>Lipids</topic><topic>Male</topic><topic>Mediterranean diet</topic><topic>Middle Aged</topic><topic>Proteins</topic><topic>Randomized controlled trial</topic><topic>Sexual Dysfunction, Physiological - complications</topic><topic>Type 2 diabetes</topic><topic>Women</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Maiorino, Maria Ida</creatorcontrib><creatorcontrib>Bellastella, Giuseppe</creatorcontrib><creatorcontrib>Caputo, Mariangela</creatorcontrib><creatorcontrib>Castaldo, Filomena</creatorcontrib><creatorcontrib>Improta, Maria Rosaria</creatorcontrib><creatorcontrib>Giugliano, Dario</creatorcontrib><creatorcontrib>Esposito, Katherine</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Nursing and Allied Health Journals</collection><collection>Health & Medical Collection (Proquest)</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>British Nursing Database</collection><collection>British Nursing Index</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>British Nursing Index (BNI) (1985 to Present)</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>British Nursing Index</collection><collection>Consumer Health Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Family Health Database (Proquest)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest research library</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of diabetes and its complications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Maiorino, Maria Ida</au><au>Bellastella, Giuseppe</au><au>Caputo, Mariangela</au><au>Castaldo, Filomena</au><au>Improta, Maria Rosaria</au><au>Giugliano, Dario</au><au>Esposito, Katherine</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of Mediterranean diet on sexual function in people with newly-diagnosed type 2 diabetes: The MÈDITA trial</atitle><jtitle>Journal of diabetes and its complications</jtitle><addtitle>J Diabetes Complications</addtitle><date>2016-11-01</date><risdate>2016</risdate><volume>30</volume><issue>8</issue><spage>1519</spage><epage>1524</epage><pages>1519-1524</pages><issn>1056-8727</issn><eissn>1873-460X</eissn><abstract>Abstract Aims To assess the long-term effect of Mediterranean diet, as compared with low-fat diet, on sexual function in patients with newly-diagnosed type 2 diabetes. Methods In a randomized clinical trial, with a total follow-up of 8.1 years, 215 men and women with newly diagnosed type 2 diabetes were assigned to Mediterranean diet (n = 108) or a low-fat diet (n = 107).The primary outcome measures were changes of erectile function (IIEF) in diabetic men and of female sexual function (FSFI) in diabetic women. Results There was no difference in baseline sexual function in men (n = 54 vs 52) or women (n = 54 vs 55) randomized to Mediterranean diet or low-fat diet, respectively (P = 0.287, P = 0.815). Over the entire follow-up, the changes of the primary outcomes were significantly lower in the Mediterranean diet group compared with the low-fat group: IIEF and FSFI showed a significantly lesser decrease (1.22 and 1.18, respectively, P = 0.024 and 0.019) with the Mediterranean diet. Baseline C-reactive protein levels predicted ED in men, but not FSD in women. Conclusions Among persons with newly diagnosed type 2 diabetes, a Mediterranean diet reduced the deterioration of sexual function over time in both sexes.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>27614727</pmid><doi>10.1016/j.jdiacomp.2016.08.007</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0003-4659-7546</orcidid></addata></record> |
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| subjects | Adult Alcohol C-Reactive Protein - analysis Carbohydrates Cardiovascular disease Diabetes Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - physiopathology Diet Diet, Fat-Restricted Diet, Mediterranean Endocrinology & Metabolism Erectile Dysfunction - complications Fatty acids Female Female sexual dysfunction Health risk assessment Humans Legumes Lipids Male Mediterranean diet Middle Aged Proteins Randomized controlled trial Sexual Dysfunction, Physiological - complications Type 2 diabetes Women |
| title | Effects of Mediterranean diet on sexual function in people with newly-diagnosed type 2 diabetes: The MÈDITA trial |
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