ExplorinG frailty and mild cognitive impairmEnt in kidney tRansplantation to predict biomedicAl, psychosocial and health cost outcomeS (GERAS): protocol of a nationwide prospective cohort study
Aim To present the rationale, design and methodology of the GERAS project, which examines whether assessment of frailty and mild cognitive impairment could enhance risk prediction for biomedical, psychosocial outcomes and foster efficient resource allocation in kidney transplantation. Background For...
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| Veröffentlicht in: | Journal of advanced nursing 2017-03, Vol.73 (3), p.716-734 |
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| creator | Mauthner, Oliver Claes, Veerle Walston, Jeremy Engberg, Sandra Binet, Isabelle Dickenmann, Michael Golshayan, Déla Hadaya, Karine Huynh‐Do, Uyen Calciolari, Stefano De Geest, Sabina Berben, Lut Burkhalter, Hanna Denhaerynck, Kris Helmy, Remon Kirsch, Monika Leppla, Lynn Struker, Marian Boehler, Annette Gerull, Sabine Koller, Michael T Boely, Elsa Catana, Emmanuelle Simcox, Amira Seiler, Annina Klaghofer, Richard Künzler‐Heule, Patrizia Beckmann, Sonja Achermann, Rita Amico, Patrizia Aubert, John‐David Baumann, Philippe Beldi, Guido Benden, Christian Berger, Christoph Bochud, Pierre‐Yves Boely, Elsa Bucher, Heiner Bühler, Leo Carell, Thierry Catana, Emmanuelle Chalandon, Yves Rougemont, Olivier Duchosal, Michel Fehr, Thomas Ferrari‐Lacraz, Sylvie Garzoni, Christian Soccal, Paola Gasche Giostra, Emiliano Halter, Jörg Heim, Dominik Hess, Christoph Hillinger, Sven Hirsch, Hans H. Hofbauer, Günther Immer, Franz Klaghofer, Richard Koller, Michael Laesser, Bettina Lehmann, Roger Lovis, Christian Manuel, Oriol Marti, Hans‐Peter Martin, Pierre Yves Martinolli, Luca Meylan, Pascal Mohacsi, Paul Morard, Isabelle Morel, Philippe Mueller, Ulrike Mueller, Nicolas J Mueller‐McKenna, Helen Müller, Antonia Müller, Thomas Müllhaupt, Beat Nadal, David Pascual, Manuel Passweg, Jakob Ziegler, Chantal Piot Rick, Juliane Roosnek, Eddy Rosselet, Anne Rothlin, Silvia Ruschitzka, Frank Schanz, Urs Schaub, Stefan Schnyder, Aurelia Seiler, Christian Stampf, Susanne Steiger, Jürg Stirnimann, Guido Toso, Christian Delden, Christian Venetz, Jean‐Pierre Villard, Jean Wick, Madeleine Wilhelm, Markus Yerly, Patrick |
| description | Aim
To present the rationale, design and methodology of the GERAS project, which examines whether assessment of frailty and mild cognitive impairment could enhance risk prediction for biomedical, psychosocial outcomes and foster efficient resource allocation in kidney transplantation.
Background
For the burgeoning cohort of older patients considered for kidney transplantation, evidence gaps regarding frailty and mild cognitive impairment limit clinical decision‐making and medical management. As known risk factors for ‘hard’ clinical outcomes in chronic illness, both require further study in transplantation. Integrating these and other bio‐psychosocial factors into a comprehensive pre‐transplant patient assessment will provide insights regarding economic implications and may improve risk prediction.
Design
A nation‐wide multi‐centre prospective cohort study nested in the Swiss Transplant Cohort Study.
Methods
Our nationally representative convenience sample includes 250 adult kidney transplant recipients. Data sources include the Swiss Transplant Cohort Study and primary data collected at time of transplantation, 6 months, 1 and 2 years post‐transplant via established measures (the Montreal Cognitive Assessment, Psychosocial Questionnaire, Fried Frailty Instrument and a blood analysis), investigator‐developed instruments and datasets compiled by hospitals’ management control units, sickness funds, the Swiss Federal Statistical Office and the European Renal Association. Descriptive, competing risk survival and mixed effects analyses will be performed. Research Ethics Committee approval was obtained in January 2016.
Discussion
This pioneering project jointly examines frailty and mild cognitive impairment from bio‐psychosocial and health economic perspectives. Results may significantly inform risk prediction, care tailoring and resource optimization to improve health outcomes in the ageing kidney transplant cohort. |
| doi_str_mv | 10.1111/jan.13179 |
| format | Article |
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Claes, Veerle ; Walston, Jeremy ; Engberg, Sandra ; Binet, Isabelle ; Dickenmann, Michael ; Golshayan, Déla ; Hadaya, Karine ; Huynh‐Do, Uyen ; Calciolari, Stefano ; De Geest, Sabina ; Berben, Lut ; Burkhalter, Hanna ; Denhaerynck, Kris ; Helmy, Remon ; Kirsch, Monika ; Leppla, Lynn ; Struker, Marian ; Boehler, Annette ; Gerull, Sabine ; Koller, Michael T ; Boely, Elsa ; Catana, Emmanuelle ; Simcox, Amira ; Seiler, Annina ; Klaghofer, Richard ; Künzler‐Heule, Patrizia ; Beckmann, Sonja ; Achermann, Rita ; Amico, Patrizia ; Aubert, John‐David ; Baumann, Philippe ; Beldi, Guido ; Benden, Christian ; Berger, Christoph ; Bochud, Pierre‐Yves ; Boely, Elsa ; Bucher, Heiner ; Bühler, Leo ; Carell, Thierry ; Catana, Emmanuelle ; Chalandon, Yves ; Rougemont, Olivier ; Duchosal, Michel ; Fehr, Thomas ; Ferrari‐Lacraz, Sylvie ; Garzoni, Christian ; Soccal, Paola Gasche ; Giostra, Emiliano ; Halter, Jörg ; Heim, Dominik ; Hess, Christoph ; Hillinger, Sven ; Hirsch, Hans H. ; Hofbauer, Günther ; Immer, Franz ; Klaghofer, Richard ; Koller, Michael ; Laesser, Bettina ; Lehmann, Roger ; Lovis, Christian ; Manuel, Oriol ; Marti, Hans‐Peter ; Martin, Pierre Yves ; Martinolli, Luca ; Meylan, Pascal ; Mohacsi, Paul ; Morard, Isabelle ; Morel, Philippe ; Mueller, Ulrike ; Mueller, Nicolas J ; Mueller‐McKenna, Helen ; Müller, Antonia ; Müller, Thomas ; Müllhaupt, Beat ; Nadal, David ; Pascual, Manuel ; Passweg, Jakob ; Ziegler, Chantal Piot ; Rick, Juliane ; Roosnek, Eddy ; Rosselet, Anne ; Rothlin, Silvia ; Ruschitzka, Frank ; Schanz, Urs ; Schaub, Stefan ; Schnyder, Aurelia ; Seiler, Christian ; Stampf, Susanne ; Steiger, Jürg ; Stirnimann, Guido ; Toso, Christian ; Delden, Christian ; Venetz, Jean‐Pierre ; Villard, Jean ; Wick, Madeleine ; Wilhelm, Markus ; Yerly, Patrick</creator><creatorcontrib>Mauthner, Oliver ; Claes, Veerle ; Walston, Jeremy ; Engberg, Sandra ; Binet, Isabelle ; Dickenmann, Michael ; Golshayan, Déla ; Hadaya, Karine ; Huynh‐Do, Uyen ; Calciolari, Stefano ; De Geest, Sabina ; Berben, Lut ; Burkhalter, Hanna ; Denhaerynck, Kris ; Helmy, Remon ; Kirsch, Monika ; Leppla, Lynn ; Struker, Marian ; Boehler, Annette ; Gerull, Sabine ; Koller, Michael T ; Boely, Elsa ; Catana, Emmanuelle ; Simcox, Amira ; Seiler, Annina ; Klaghofer, Richard ; Künzler‐Heule, Patrizia ; Beckmann, Sonja ; Achermann, Rita ; Amico, Patrizia ; Aubert, John‐David ; Baumann, Philippe ; Beldi, Guido ; Benden, Christian ; Berger, Christoph ; Bochud, Pierre‐Yves ; Boely, Elsa ; Bucher, Heiner ; Bühler, Leo ; Carell, Thierry ; Catana, Emmanuelle ; Chalandon, Yves ; Rougemont, Olivier ; Duchosal, Michel ; Fehr, Thomas ; Ferrari‐Lacraz, Sylvie ; Garzoni, Christian ; Soccal, Paola Gasche ; Giostra, Emiliano ; Halter, Jörg ; Heim, Dominik ; Hess, Christoph ; Hillinger, Sven ; Hirsch, Hans H. ; Hofbauer, Günther ; Immer, Franz ; Klaghofer, Richard ; Koller, Michael ; Laesser, Bettina ; Lehmann, Roger ; Lovis, Christian ; Manuel, Oriol ; Marti, Hans‐Peter ; Martin, Pierre Yves ; Martinolli, Luca ; Meylan, Pascal ; Mohacsi, Paul ; Morard, Isabelle ; Morel, Philippe ; Mueller, Ulrike ; Mueller, Nicolas J ; Mueller‐McKenna, Helen ; Müller, Antonia ; Müller, Thomas ; Müllhaupt, Beat ; Nadal, David ; Pascual, Manuel ; Passweg, Jakob ; Ziegler, Chantal Piot ; Rick, Juliane ; Roosnek, Eddy ; Rosselet, Anne ; Rothlin, Silvia ; Ruschitzka, Frank ; Schanz, Urs ; Schaub, Stefan ; Schnyder, Aurelia ; Seiler, Christian ; Stampf, Susanne ; Steiger, Jürg ; Stirnimann, Guido ; Toso, Christian ; Delden, Christian ; Venetz, Jean‐Pierre ; Villard, Jean ; Wick, Madeleine ; Wilhelm, Markus ; Yerly, Patrick ; GERAS study consortium; For the Psychosocial Interest Group; Swiss Transplant Cohort Study (STCS) ; the GERAS study consortium; For the Psychosocial Interest Group; Swiss Transplant Cohort Study (STCS)</creatorcontrib><description>Aim
To present the rationale, design and methodology of the GERAS project, which examines whether assessment of frailty and mild cognitive impairment could enhance risk prediction for biomedical, psychosocial outcomes and foster efficient resource allocation in kidney transplantation.
Background
For the burgeoning cohort of older patients considered for kidney transplantation, evidence gaps regarding frailty and mild cognitive impairment limit clinical decision‐making and medical management. As known risk factors for ‘hard’ clinical outcomes in chronic illness, both require further study in transplantation. Integrating these and other bio‐psychosocial factors into a comprehensive pre‐transplant patient assessment will provide insights regarding economic implications and may improve risk prediction.
Design
A nation‐wide multi‐centre prospective cohort study nested in the Swiss Transplant Cohort Study.
Methods
Our nationally representative convenience sample includes 250 adult kidney transplant recipients. Data sources include the Swiss Transplant Cohort Study and primary data collected at time of transplantation, 6 months, 1 and 2 years post‐transplant via established measures (the Montreal Cognitive Assessment, Psychosocial Questionnaire, Fried Frailty Instrument and a blood analysis), investigator‐developed instruments and datasets compiled by hospitals’ management control units, sickness funds, the Swiss Federal Statistical Office and the European Renal Association. Descriptive, competing risk survival and mixed effects analyses will be performed. Research Ethics Committee approval was obtained in January 2016.
Discussion
This pioneering project jointly examines frailty and mild cognitive impairment from bio‐psychosocial and health economic perspectives. Results may significantly inform risk prediction, care tailoring and resource optimization to improve health outcomes in the ageing kidney transplant cohort.</description><identifier>ISSN: 0309-2402</identifier><identifier>EISSN: 1365-2648</identifier><identifier>DOI: 10.1111/jan.13179</identifier><identifier>PMID: 27731953</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Aged ; Aged, 80 and over ; Cognition & reasoning ; Cognition Disorders - epidemiology ; Frail Elderly ; Frailty ; Health Care Costs ; health economics ; Humans ; Kidney Transplantation ; Kidneys ; midwives ; mild cognitive impairment ; nurses ; Nursing ; older patients ; Prospective Studies ; Risk Assessment ; risk prediction, multi‐centre prospective cohort study ; Switzerland ; Transplants & implants</subject><ispartof>Journal of advanced nursing, 2017-03, Vol.73 (3), p.716-734</ispartof><rights>2016 John Wiley & Sons Ltd</rights><rights>2016 John Wiley & Sons Ltd.</rights><rights>2017 John Wiley & Sons Ltd</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4499-2e8a127e613096e48de862803cc29e6d561925980ff3efb8ba565f75be53d8cf3</citedby><cites>FETCH-LOGICAL-c4499-2e8a127e613096e48de862803cc29e6d561925980ff3efb8ba565f75be53d8cf3</cites><orcidid>0000-0002-6207-0069</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fjan.13179$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fjan.13179$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,30976,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27731953$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mauthner, Oliver</creatorcontrib><creatorcontrib>Claes, Veerle</creatorcontrib><creatorcontrib>Walston, Jeremy</creatorcontrib><creatorcontrib>Engberg, Sandra</creatorcontrib><creatorcontrib>Binet, Isabelle</creatorcontrib><creatorcontrib>Dickenmann, Michael</creatorcontrib><creatorcontrib>Golshayan, Déla</creatorcontrib><creatorcontrib>Hadaya, Karine</creatorcontrib><creatorcontrib>Huynh‐Do, Uyen</creatorcontrib><creatorcontrib>Calciolari, Stefano</creatorcontrib><creatorcontrib>De Geest, Sabina</creatorcontrib><creatorcontrib>Berben, Lut</creatorcontrib><creatorcontrib>Burkhalter, Hanna</creatorcontrib><creatorcontrib>Denhaerynck, Kris</creatorcontrib><creatorcontrib>Helmy, Remon</creatorcontrib><creatorcontrib>Kirsch, Monika</creatorcontrib><creatorcontrib>Leppla, Lynn</creatorcontrib><creatorcontrib>Struker, Marian</creatorcontrib><creatorcontrib>Boehler, Annette</creatorcontrib><creatorcontrib>Gerull, Sabine</creatorcontrib><creatorcontrib>Koller, Michael T</creatorcontrib><creatorcontrib>Boely, Elsa</creatorcontrib><creatorcontrib>Catana, Emmanuelle</creatorcontrib><creatorcontrib>Simcox, Amira</creatorcontrib><creatorcontrib>Seiler, Annina</creatorcontrib><creatorcontrib>Klaghofer, Richard</creatorcontrib><creatorcontrib>Künzler‐Heule, Patrizia</creatorcontrib><creatorcontrib>Beckmann, Sonja</creatorcontrib><creatorcontrib>Achermann, Rita</creatorcontrib><creatorcontrib>Amico, Patrizia</creatorcontrib><creatorcontrib>Aubert, John‐David</creatorcontrib><creatorcontrib>Baumann, Philippe</creatorcontrib><creatorcontrib>Beldi, Guido</creatorcontrib><creatorcontrib>Benden, Christian</creatorcontrib><creatorcontrib>Berger, Christoph</creatorcontrib><creatorcontrib>Bochud, Pierre‐Yves</creatorcontrib><creatorcontrib>Boely, Elsa</creatorcontrib><creatorcontrib>Bucher, Heiner</creatorcontrib><creatorcontrib>Bühler, Leo</creatorcontrib><creatorcontrib>Carell, Thierry</creatorcontrib><creatorcontrib>Catana, Emmanuelle</creatorcontrib><creatorcontrib>Chalandon, Yves</creatorcontrib><creatorcontrib>Rougemont, Olivier</creatorcontrib><creatorcontrib>Duchosal, Michel</creatorcontrib><creatorcontrib>Fehr, Thomas</creatorcontrib><creatorcontrib>Ferrari‐Lacraz, Sylvie</creatorcontrib><creatorcontrib>Garzoni, Christian</creatorcontrib><creatorcontrib>Soccal, Paola Gasche</creatorcontrib><creatorcontrib>Giostra, Emiliano</creatorcontrib><creatorcontrib>Halter, Jörg</creatorcontrib><creatorcontrib>Heim, Dominik</creatorcontrib><creatorcontrib>Hess, Christoph</creatorcontrib><creatorcontrib>Hillinger, Sven</creatorcontrib><creatorcontrib>Hirsch, Hans H.</creatorcontrib><creatorcontrib>Hofbauer, Günther</creatorcontrib><creatorcontrib>Immer, Franz</creatorcontrib><creatorcontrib>Klaghofer, Richard</creatorcontrib><creatorcontrib>Koller, Michael</creatorcontrib><creatorcontrib>Laesser, Bettina</creatorcontrib><creatorcontrib>Lehmann, Roger</creatorcontrib><creatorcontrib>Lovis, Christian</creatorcontrib><creatorcontrib>Manuel, Oriol</creatorcontrib><creatorcontrib>Marti, Hans‐Peter</creatorcontrib><creatorcontrib>Martin, Pierre Yves</creatorcontrib><creatorcontrib>Martinolli, Luca</creatorcontrib><creatorcontrib>Meylan, Pascal</creatorcontrib><creatorcontrib>Mohacsi, Paul</creatorcontrib><creatorcontrib>Morard, Isabelle</creatorcontrib><creatorcontrib>Morel, Philippe</creatorcontrib><creatorcontrib>Mueller, Ulrike</creatorcontrib><creatorcontrib>Mueller, Nicolas J</creatorcontrib><creatorcontrib>Mueller‐McKenna, Helen</creatorcontrib><creatorcontrib>Müller, Antonia</creatorcontrib><creatorcontrib>Müller, Thomas</creatorcontrib><creatorcontrib>Müllhaupt, Beat</creatorcontrib><creatorcontrib>Nadal, David</creatorcontrib><creatorcontrib>Pascual, Manuel</creatorcontrib><creatorcontrib>Passweg, Jakob</creatorcontrib><creatorcontrib>Ziegler, Chantal Piot</creatorcontrib><creatorcontrib>Rick, Juliane</creatorcontrib><creatorcontrib>Roosnek, Eddy</creatorcontrib><creatorcontrib>Rosselet, Anne</creatorcontrib><creatorcontrib>Rothlin, Silvia</creatorcontrib><creatorcontrib>Ruschitzka, Frank</creatorcontrib><creatorcontrib>Schanz, Urs</creatorcontrib><creatorcontrib>Schaub, Stefan</creatorcontrib><creatorcontrib>Schnyder, Aurelia</creatorcontrib><creatorcontrib>Seiler, Christian</creatorcontrib><creatorcontrib>Stampf, Susanne</creatorcontrib><creatorcontrib>Steiger, Jürg</creatorcontrib><creatorcontrib>Stirnimann, Guido</creatorcontrib><creatorcontrib>Toso, Christian</creatorcontrib><creatorcontrib>Delden, Christian</creatorcontrib><creatorcontrib>Venetz, Jean‐Pierre</creatorcontrib><creatorcontrib>Villard, Jean</creatorcontrib><creatorcontrib>Wick, Madeleine</creatorcontrib><creatorcontrib>Wilhelm, Markus</creatorcontrib><creatorcontrib>Yerly, Patrick</creatorcontrib><creatorcontrib>GERAS study consortium; For the Psychosocial Interest Group; Swiss Transplant Cohort Study (STCS)</creatorcontrib><creatorcontrib>the GERAS study consortium; For the Psychosocial Interest Group; Swiss Transplant Cohort Study (STCS)</creatorcontrib><title>ExplorinG frailty and mild cognitive impairmEnt in kidney tRansplantation to predict biomedicAl, psychosocial and health cost outcomeS (GERAS): protocol of a nationwide prospective cohort study</title><title>Journal of advanced nursing</title><addtitle>J Adv Nurs</addtitle><description>Aim
To present the rationale, design and methodology of the GERAS project, which examines whether assessment of frailty and mild cognitive impairment could enhance risk prediction for biomedical, psychosocial outcomes and foster efficient resource allocation in kidney transplantation.
Background
For the burgeoning cohort of older patients considered for kidney transplantation, evidence gaps regarding frailty and mild cognitive impairment limit clinical decision‐making and medical management. As known risk factors for ‘hard’ clinical outcomes in chronic illness, both require further study in transplantation. Integrating these and other bio‐psychosocial factors into a comprehensive pre‐transplant patient assessment will provide insights regarding economic implications and may improve risk prediction.
Design
A nation‐wide multi‐centre prospective cohort study nested in the Swiss Transplant Cohort Study.
Methods
Our nationally representative convenience sample includes 250 adult kidney transplant recipients. Data sources include the Swiss Transplant Cohort Study and primary data collected at time of transplantation, 6 months, 1 and 2 years post‐transplant via established measures (the Montreal Cognitive Assessment, Psychosocial Questionnaire, Fried Frailty Instrument and a blood analysis), investigator‐developed instruments and datasets compiled by hospitals’ management control units, sickness funds, the Swiss Federal Statistical Office and the European Renal Association. Descriptive, competing risk survival and mixed effects analyses will be performed. Research Ethics Committee approval was obtained in January 2016.
Discussion
This pioneering project jointly examines frailty and mild cognitive impairment from bio‐psychosocial and health economic perspectives. Results may significantly inform risk prediction, care tailoring and resource optimization to improve health outcomes in the ageing kidney transplant cohort.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Cognition & reasoning</subject><subject>Cognition Disorders - epidemiology</subject><subject>Frail Elderly</subject><subject>Frailty</subject><subject>Health Care Costs</subject><subject>health economics</subject><subject>Humans</subject><subject>Kidney Transplantation</subject><subject>Kidneys</subject><subject>midwives</subject><subject>mild cognitive impairment</subject><subject>nurses</subject><subject>Nursing</subject><subject>older patients</subject><subject>Prospective Studies</subject><subject>Risk Assessment</subject><subject>risk prediction, multi‐centre prospective cohort study</subject><subject>Switzerland</subject><subject>Transplants & 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Jürg</creator><creator>Stirnimann, Guido</creator><creator>Toso, Christian</creator><creator>Delden, Christian</creator><creator>Venetz, Jean‐Pierre</creator><creator>Villard, Jean</creator><creator>Wick, Madeleine</creator><creator>Wilhelm, Markus</creator><creator>Yerly, Patrick</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QJ</scope><scope>ASE</scope><scope>FPQ</scope><scope>K6X</scope><scope>NAPCQ</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-6207-0069</orcidid></search><sort><creationdate>201703</creationdate><title>ExplorinG frailty and mild cognitive impairmEnt in kidney tRansplantation to predict biomedicAl, psychosocial and health cost outcomeS (GERAS): protocol of a nationwide prospective cohort study</title><author>Mauthner, Oliver ; Claes, Veerle ; Walston, Jeremy ; Engberg, Sandra ; Binet, Isabelle ; Dickenmann, Michael ; Golshayan, Déla ; Hadaya, Karine ; Huynh‐Do, Uyen ; Calciolari, Stefano ; De Geest, Sabina ; Berben, Lut ; Burkhalter, Hanna ; Denhaerynck, Kris ; Helmy, Remon ; Kirsch, Monika ; Leppla, Lynn ; Struker, Marian ; Boehler, Annette ; Gerull, Sabine ; Koller, Michael T ; Boely, Elsa ; Catana, Emmanuelle ; Simcox, Amira ; Seiler, Annina ; Klaghofer, Richard ; Künzler‐Heule, Patrizia ; Beckmann, Sonja ; Achermann, Rita ; Amico, Patrizia ; Aubert, John‐David ; Baumann, Philippe ; Beldi, Guido ; Benden, Christian ; Berger, Christoph ; Bochud, Pierre‐Yves ; Boely, Elsa ; Bucher, Heiner ; Bühler, Leo ; Carell, Thierry ; Catana, Emmanuelle ; Chalandon, Yves ; Rougemont, Olivier ; Duchosal, Michel ; Fehr, Thomas ; Ferrari‐Lacraz, Sylvie ; Garzoni, Christian ; Soccal, Paola Gasche ; Giostra, Emiliano ; Halter, Jörg ; Heim, Dominik ; Hess, Christoph ; Hillinger, Sven ; Hirsch, Hans H. ; Hofbauer, Günther ; Immer, Franz ; Klaghofer, Richard ; Koller, Michael ; Laesser, Bettina ; Lehmann, Roger ; Lovis, Christian ; Manuel, Oriol ; Marti, Hans‐Peter ; Martin, Pierre Yves ; Martinolli, Luca ; Meylan, Pascal ; Mohacsi, Paul ; Morard, Isabelle ; Morel, Philippe ; Mueller, Ulrike ; Mueller, Nicolas J ; Mueller‐McKenna, Helen ; Müller, Antonia ; Müller, Thomas ; Müllhaupt, Beat ; Nadal, David ; Pascual, Manuel ; Passweg, Jakob ; Ziegler, Chantal Piot ; Rick, Juliane ; Roosnek, Eddy ; Rosselet, Anne ; Rothlin, Silvia ; Ruschitzka, Frank ; Schanz, Urs ; Schaub, Stefan ; Schnyder, Aurelia ; Seiler, Christian ; Stampf, Susanne ; Steiger, Jürg ; Stirnimann, Guido ; Toso, Christian ; Delden, Christian ; Venetz, Jean‐Pierre ; Villard, Jean ; Wick, Madeleine ; Wilhelm, Markus ; Yerly, Patrick</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4499-2e8a127e613096e48de862803cc29e6d561925980ff3efb8ba565f75be53d8cf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Cognition & reasoning</topic><topic>Cognition Disorders - epidemiology</topic><topic>Frail Elderly</topic><topic>Frailty</topic><topic>Health Care Costs</topic><topic>health economics</topic><topic>Humans</topic><topic>Kidney Transplantation</topic><topic>Kidneys</topic><topic>midwives</topic><topic>mild cognitive impairment</topic><topic>nurses</topic><topic>Nursing</topic><topic>older patients</topic><topic>Prospective Studies</topic><topic>Risk Assessment</topic><topic>risk prediction, multi‐centre prospective cohort study</topic><topic>Switzerland</topic><topic>Transplants & implants</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mauthner, Oliver</creatorcontrib><creatorcontrib>Claes, Veerle</creatorcontrib><creatorcontrib>Walston, Jeremy</creatorcontrib><creatorcontrib>Engberg, Sandra</creatorcontrib><creatorcontrib>Binet, Isabelle</creatorcontrib><creatorcontrib>Dickenmann, Michael</creatorcontrib><creatorcontrib>Golshayan, Déla</creatorcontrib><creatorcontrib>Hadaya, Karine</creatorcontrib><creatorcontrib>Huynh‐Do, Uyen</creatorcontrib><creatorcontrib>Calciolari, Stefano</creatorcontrib><creatorcontrib>De Geest, Sabina</creatorcontrib><creatorcontrib>Berben, Lut</creatorcontrib><creatorcontrib>Burkhalter, Hanna</creatorcontrib><creatorcontrib>Denhaerynck, Kris</creatorcontrib><creatorcontrib>Helmy, Remon</creatorcontrib><creatorcontrib>Kirsch, Monika</creatorcontrib><creatorcontrib>Leppla, Lynn</creatorcontrib><creatorcontrib>Struker, Marian</creatorcontrib><creatorcontrib>Boehler, Annette</creatorcontrib><creatorcontrib>Gerull, Sabine</creatorcontrib><creatorcontrib>Koller, Michael T</creatorcontrib><creatorcontrib>Boely, Elsa</creatorcontrib><creatorcontrib>Catana, Emmanuelle</creatorcontrib><creatorcontrib>Simcox, Amira</creatorcontrib><creatorcontrib>Seiler, Annina</creatorcontrib><creatorcontrib>Klaghofer, Richard</creatorcontrib><creatorcontrib>Künzler‐Heule, Patrizia</creatorcontrib><creatorcontrib>Beckmann, Sonja</creatorcontrib><creatorcontrib>Achermann, Rita</creatorcontrib><creatorcontrib>Amico, Patrizia</creatorcontrib><creatorcontrib>Aubert, John‐David</creatorcontrib><creatorcontrib>Baumann, Philippe</creatorcontrib><creatorcontrib>Beldi, Guido</creatorcontrib><creatorcontrib>Benden, Christian</creatorcontrib><creatorcontrib>Berger, Christoph</creatorcontrib><creatorcontrib>Bochud, Pierre‐Yves</creatorcontrib><creatorcontrib>Boely, Elsa</creatorcontrib><creatorcontrib>Bucher, Heiner</creatorcontrib><creatorcontrib>Bühler, Leo</creatorcontrib><creatorcontrib>Carell, Thierry</creatorcontrib><creatorcontrib>Catana, Emmanuelle</creatorcontrib><creatorcontrib>Chalandon, Yves</creatorcontrib><creatorcontrib>Rougemont, Olivier</creatorcontrib><creatorcontrib>Duchosal, Michel</creatorcontrib><creatorcontrib>Fehr, Thomas</creatorcontrib><creatorcontrib>Ferrari‐Lacraz, Sylvie</creatorcontrib><creatorcontrib>Garzoni, Christian</creatorcontrib><creatorcontrib>Soccal, Paola Gasche</creatorcontrib><creatorcontrib>Giostra, Emiliano</creatorcontrib><creatorcontrib>Halter, Jörg</creatorcontrib><creatorcontrib>Heim, Dominik</creatorcontrib><creatorcontrib>Hess, Christoph</creatorcontrib><creatorcontrib>Hillinger, Sven</creatorcontrib><creatorcontrib>Hirsch, Hans H.</creatorcontrib><creatorcontrib>Hofbauer, Günther</creatorcontrib><creatorcontrib>Immer, Franz</creatorcontrib><creatorcontrib>Klaghofer, Richard</creatorcontrib><creatorcontrib>Koller, Michael</creatorcontrib><creatorcontrib>Laesser, Bettina</creatorcontrib><creatorcontrib>Lehmann, Roger</creatorcontrib><creatorcontrib>Lovis, Christian</creatorcontrib><creatorcontrib>Manuel, Oriol</creatorcontrib><creatorcontrib>Marti, Hans‐Peter</creatorcontrib><creatorcontrib>Martin, Pierre Yves</creatorcontrib><creatorcontrib>Martinolli, Luca</creatorcontrib><creatorcontrib>Meylan, Pascal</creatorcontrib><creatorcontrib>Mohacsi, Paul</creatorcontrib><creatorcontrib>Morard, Isabelle</creatorcontrib><creatorcontrib>Morel, Philippe</creatorcontrib><creatorcontrib>Mueller, Ulrike</creatorcontrib><creatorcontrib>Mueller, Nicolas J</creatorcontrib><creatorcontrib>Mueller‐McKenna, Helen</creatorcontrib><creatorcontrib>Müller, Antonia</creatorcontrib><creatorcontrib>Müller, Thomas</creatorcontrib><creatorcontrib>Müllhaupt, Beat</creatorcontrib><creatorcontrib>Nadal, David</creatorcontrib><creatorcontrib>Pascual, Manuel</creatorcontrib><creatorcontrib>Passweg, Jakob</creatorcontrib><creatorcontrib>Ziegler, Chantal Piot</creatorcontrib><creatorcontrib>Rick, Juliane</creatorcontrib><creatorcontrib>Roosnek, Eddy</creatorcontrib><creatorcontrib>Rosselet, Anne</creatorcontrib><creatorcontrib>Rothlin, Silvia</creatorcontrib><creatorcontrib>Ruschitzka, Frank</creatorcontrib><creatorcontrib>Schanz, Urs</creatorcontrib><creatorcontrib>Schaub, Stefan</creatorcontrib><creatorcontrib>Schnyder, Aurelia</creatorcontrib><creatorcontrib>Seiler, Christian</creatorcontrib><creatorcontrib>Stampf, Susanne</creatorcontrib><creatorcontrib>Steiger, Jürg</creatorcontrib><creatorcontrib>Stirnimann, Guido</creatorcontrib><creatorcontrib>Toso, Christian</creatorcontrib><creatorcontrib>Delden, Christian</creatorcontrib><creatorcontrib>Venetz, Jean‐Pierre</creatorcontrib><creatorcontrib>Villard, Jean</creatorcontrib><creatorcontrib>Wick, Madeleine</creatorcontrib><creatorcontrib>Wilhelm, Markus</creatorcontrib><creatorcontrib>Yerly, Patrick</creatorcontrib><creatorcontrib>GERAS study consortium; For the Psychosocial Interest Group; Swiss Transplant Cohort Study (STCS)</creatorcontrib><creatorcontrib>the GERAS study consortium; For the Psychosocial Interest Group; Swiss Transplant Cohort Study (STCS)</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Applied Social Sciences Index & Abstracts (ASSIA)</collection><collection>British Nursing Index</collection><collection>British Nursing Index (BNI) (1985 to Present)</collection><collection>British Nursing Index</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of advanced nursing</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mauthner, Oliver</au><au>Claes, Veerle</au><au>Walston, Jeremy</au><au>Engberg, Sandra</au><au>Binet, Isabelle</au><au>Dickenmann, Michael</au><au>Golshayan, Déla</au><au>Hadaya, Karine</au><au>Huynh‐Do, Uyen</au><au>Calciolari, Stefano</au><au>De Geest, Sabina</au><au>Berben, Lut</au><au>Burkhalter, Hanna</au><au>Denhaerynck, Kris</au><au>Helmy, Remon</au><au>Kirsch, Monika</au><au>Leppla, Lynn</au><au>Struker, Marian</au><au>Boehler, Annette</au><au>Gerull, Sabine</au><au>Koller, Michael T</au><au>Boely, Elsa</au><au>Catana, Emmanuelle</au><au>Simcox, Amira</au><au>Seiler, Annina</au><au>Klaghofer, Richard</au><au>Künzler‐Heule, Patrizia</au><au>Beckmann, Sonja</au><au>Achermann, Rita</au><au>Amico, Patrizia</au><au>Aubert, John‐David</au><au>Baumann, Philippe</au><au>Beldi, Guido</au><au>Benden, Christian</au><au>Berger, Christoph</au><au>Bochud, Pierre‐Yves</au><au>Boely, Elsa</au><au>Bucher, Heiner</au><au>Bühler, Leo</au><au>Carell, Thierry</au><au>Catana, Emmanuelle</au><au>Chalandon, Yves</au><au>Rougemont, Olivier</au><au>Duchosal, Michel</au><au>Fehr, Thomas</au><au>Ferrari‐Lacraz, Sylvie</au><au>Garzoni, Christian</au><au>Soccal, Paola Gasche</au><au>Giostra, Emiliano</au><au>Halter, Jörg</au><au>Heim, Dominik</au><au>Hess, Christoph</au><au>Hillinger, Sven</au><au>Hirsch, Hans H.</au><au>Hofbauer, Günther</au><au>Immer, Franz</au><au>Klaghofer, Richard</au><au>Koller, Michael</au><au>Laesser, Bettina</au><au>Lehmann, Roger</au><au>Lovis, Christian</au><au>Manuel, Oriol</au><au>Marti, Hans‐Peter</au><au>Martin, Pierre Yves</au><au>Martinolli, Luca</au><au>Meylan, Pascal</au><au>Mohacsi, Paul</au><au>Morard, Isabelle</au><au>Morel, Philippe</au><au>Mueller, Ulrike</au><au>Mueller, Nicolas J</au><au>Mueller‐McKenna, Helen</au><au>Müller, Antonia</au><au>Müller, Thomas</au><au>Müllhaupt, Beat</au><au>Nadal, David</au><au>Pascual, Manuel</au><au>Passweg, Jakob</au><au>Ziegler, Chantal Piot</au><au>Rick, Juliane</au><au>Roosnek, Eddy</au><au>Rosselet, Anne</au><au>Rothlin, Silvia</au><au>Ruschitzka, Frank</au><au>Schanz, Urs</au><au>Schaub, Stefan</au><au>Schnyder, Aurelia</au><au>Seiler, Christian</au><au>Stampf, Susanne</au><au>Steiger, Jürg</au><au>Stirnimann, Guido</au><au>Toso, Christian</au><au>Delden, Christian</au><au>Venetz, Jean‐Pierre</au><au>Villard, Jean</au><au>Wick, Madeleine</au><au>Wilhelm, Markus</au><au>Yerly, Patrick</au><aucorp>GERAS study consortium; For the Psychosocial Interest Group; Swiss Transplant Cohort Study (STCS)</aucorp><aucorp>the GERAS study consortium; For the Psychosocial Interest Group; Swiss Transplant Cohort Study (STCS)</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>ExplorinG frailty and mild cognitive impairmEnt in kidney tRansplantation to predict biomedicAl, psychosocial and health cost outcomeS (GERAS): protocol of a nationwide prospective cohort study</atitle><jtitle>Journal of advanced nursing</jtitle><addtitle>J Adv Nurs</addtitle><date>2017-03</date><risdate>2017</risdate><volume>73</volume><issue>3</issue><spage>716</spage><epage>734</epage><pages>716-734</pages><issn>0309-2402</issn><eissn>1365-2648</eissn><abstract>Aim
To present the rationale, design and methodology of the GERAS project, which examines whether assessment of frailty and mild cognitive impairment could enhance risk prediction for biomedical, psychosocial outcomes and foster efficient resource allocation in kidney transplantation.
Background
For the burgeoning cohort of older patients considered for kidney transplantation, evidence gaps regarding frailty and mild cognitive impairment limit clinical decision‐making and medical management. As known risk factors for ‘hard’ clinical outcomes in chronic illness, both require further study in transplantation. Integrating these and other bio‐psychosocial factors into a comprehensive pre‐transplant patient assessment will provide insights regarding economic implications and may improve risk prediction.
Design
A nation‐wide multi‐centre prospective cohort study nested in the Swiss Transplant Cohort Study.
Methods
Our nationally representative convenience sample includes 250 adult kidney transplant recipients. Data sources include the Swiss Transplant Cohort Study and primary data collected at time of transplantation, 6 months, 1 and 2 years post‐transplant via established measures (the Montreal Cognitive Assessment, Psychosocial Questionnaire, Fried Frailty Instrument and a blood analysis), investigator‐developed instruments and datasets compiled by hospitals’ management control units, sickness funds, the Swiss Federal Statistical Office and the European Renal Association. Descriptive, competing risk survival and mixed effects analyses will be performed. Research Ethics Committee approval was obtained in January 2016.
Discussion
This pioneering project jointly examines frailty and mild cognitive impairment from bio‐psychosocial and health economic perspectives. Results may significantly inform risk prediction, care tailoring and resource optimization to improve health outcomes in the ageing kidney transplant cohort.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>27731953</pmid><doi>10.1111/jan.13179</doi><tpages>19</tpages><orcidid>https://orcid.org/0000-0002-6207-0069</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0309-2402 |
| ispartof | Journal of advanced nursing, 2017-03, Vol.73 (3), p.716-734 |
| issn | 0309-2402 1365-2648 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1885867262 |
| source | Applied Social Sciences Index & Abstracts (ASSIA); MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Aged Aged, 80 and over Cognition & reasoning Cognition Disorders - epidemiology Frail Elderly Frailty Health Care Costs health economics Humans Kidney Transplantation Kidneys midwives mild cognitive impairment nurses Nursing older patients Prospective Studies Risk Assessment risk prediction, multi‐centre prospective cohort study Switzerland Transplants & implants |
| title | ExplorinG frailty and mild cognitive impairmEnt in kidney tRansplantation to predict biomedicAl, psychosocial and health cost outcomeS (GERAS): protocol of a nationwide prospective cohort study |
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