Liraglutide Improves Water Maze Learning and Memory Performance While Reduces Hyperphosphorylation of Tau and Neurofilaments in APP/PS1/Tau Triple Transgenic Mice

The purpose of this study was to explore how liraglutide affects AD-like pathology and cognitive function in APP/PS1/Tau triple transgenic (3 × Tg) Alzheimer disease (AD) model mice. Male 3 × Tg mice and C57BL/6 J mice were treated for 8 weeks with liraglutide (300 μg/kg/day, subcutaneous injection)...

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Veröffentlicht in:	Neurochemical research 2017-08, Vol.42 (8), p.2326-2335
Hauptverfasser:	Chen, Shuyi, Sun, Jie, Zhao, Gang, Guo, Ai, Chen, Yanlin, Fu, Rongxia, Deng, Yanqiu
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer's disease Amyloid beta-Protein Precursor - genetics Animals Biochemistry Biomedical and Life Sciences Biomedicine Body weight Brain c-Jun protein Cell Biology Change detection Cognitive ability Computer memory Degeneration Extracellular signal-regulated kinase Fasting Glucose Hippocampus Hypoglycemic Agents - pharmacology Injection Intermediate Filaments - drug effects Intermediate Filaments - metabolism JNK protein Liraglutide - pharmacology Male Maze learning Maze Learning - drug effects Maze Learning - physiology Memory Memory - drug effects Memory - physiology Mice Mice, Inbred C57BL Mice, Transgenic Neurochemistry Neurodegeneration Neurodegenerative diseases Neurofilaments Neurology Neurons Neurosciences Original Paper Phosphorylation Phosphorylation - drug effects Phosphorylation - physiology Presenilin 1 Presenilin-1 - genetics Random Allocation Rodents Saline solutions Spatial discrimination learning Spatial memory Tau protein tau Proteins - antagonists & inhibitors tau Proteins - metabolism Tissues Transcription factors Transgenic mice Weight reduction Western blotting
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