Isatin inhibits SH-SY5Y neuroblastoma cell invasion and metastasis through MAO/HIF-1α/CXCR4 signaling

Isatin was reported to possess anticancer activities through its effect on tumor proliferation, apoptosis, and metastasis in vitro and in vivo. This study aimed to elucidate the underlying mechanism behind isatin’s ability to inhibit neuroblastoma cell metastasis. Our results demonstrated that isati...

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Veröffentlicht in:	Anti-cancer drugs 2017-07, Vol.28 (6), p.645-653
Hauptverfasser:	Sun, Wenyan, Zhang, Li, Hou, Lin, Ju, Chuanxia, Zhao, Shengmin, Wei, Yaoyue
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Line, Tumor Cell Movement - drug effects Cell Proliferation - drug effects Dose-Response Relationship, Drug Enzyme Activation - drug effects Extracellular Signal-Regulated MAP Kinases - metabolism Humans Hypoxia-Inducible Factor 1, alpha Subunit - antagonists & inhibitors Hypoxia-Inducible Factor 1, alpha Subunit - biosynthesis Hypoxia-Inducible Factor 1, alpha Subunit - metabolism Isatin - pharmacology Monoamine Oxidase - metabolism Monoamine Oxidase Inhibitors - pharmacology Neoplasm Metastasis Neuroblastoma - drug therapy Neuroblastoma - metabolism Neuroblastoma - pathology Reactive Oxygen Species - metabolism Receptors, CXCR4 - antagonists & inhibitors Receptors, CXCR4 - biosynthesis Receptors, CXCR4 - metabolism Signal Transduction - drug effects
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