Corticatic Acids D and E, Polyacetylenic Geranylgeranyltransferase Type I Inhibitors, from the Marine Sponge Petrosia corticata

Two new polyacetylenic acids, corticatic acids D (2) and E (3), have been isolated from the marine sponge Petrosia corticata along with the known corticatic acid A (1) as geranylgeranyltransferase type I (GGTase I) inhibitors. Their structures were elucidated on the basis of spectroscopic and chemic...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2002-09, Vol.65 (9), p.1353-1356
Hauptverfasser:	NISHIMURA, Shinichi, MATSUNAGA, Shigeki, SHIBAZAKI, Mitsuyoshi, SUZUKI, Kenichi, HARADA, Nobuyuki, NAOKI, Hideo, FUSETANI, Nobuhiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkyl and Aryl Transferases - antagonists & inhibitors Amino Acid Sequence Animals Candida albicans - enzymology Chromatography, Liquid Corticatic acid D Corticatic acid E Demospongiae Enzyme Inhibitors - chemistry Enzyme Inhibitors - isolation & purification Enzyme Inhibitors - pharmacology Esters - chemistry Fatty Acids, Unsaturated - chemistry Fatty Acids, Unsaturated - isolation & purification Fatty Acids, Unsaturated - pharmacology geranylgeranyltransferase inhibitors Inhibitory Concentration 50 Japan Marine Molecular Structure natural products Nuclear Magnetic Resonance, Biomolecular Petrosia corticata Polyynes Porifera - chemistry Stereoisomerism
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