Trichodermamides A and B, Cytotoxic Modified Dipeptides from the Marine-Derived Fungus Trichoderma virens

Trichodermamides A (1) and B (2), two modified dipeptides, have been isolated from cultures of the marine-derived fungus Trichoderma virens. The trichodermamides possess a rare cyclic O-alkyl-oxime functionality incorporated into a six-membered ring. The structure of trichodermamide B was establishe...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2003-03, Vol.66 (3), p.423-426
Hauptverfasser:	Garo, Eliane, Starks, Courtney M, Jensen, Paul R, Fenical, William, Lobkovsky, Emil, Clardy, Jon
Format:	Artikel
Sprache:	eng
Schlagworte:	algae and seaweeds Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents Antineoplastic Agents - chemistry Antineoplastic Agents - isolation & purification Antineoplastic Agents - pharmacology Applied microbiology Biological and medical sciences cell lines Chemotherapic agents Colonic Neoplasms Crystallography, X-Ray cytotoxicity didemnum molle dipeptides Dipeptides - chemistry Dipeptides - isolation & purification Dipeptides - pharmacology Drug Screening Assays, Antitumor Fundamental and applied biological sciences. Psychology Halimeda hosts Humans Hypocrea virens Inhibitory Concentration 50 invertebrates Marine marine fungi methnes methylenes Microbiology Molecular Structure natural products oximes Papua New Guinea plant extracts spectral analysis stereochemistry Stereoisomerism Trichoderma Trichoderma - chemistry Trichoderma virens trichodermamide A trichodermamide B trichodermamides Tumor Cells, Cultured - drug effects X-ray diffraction
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