Serum metabolomic profiling highlights pathways associated with liver fat content in a general population sample

Background/Objectives: Fatty liver disease (FLD) is an important intermediate trait along the cardiometabolic disease spectrum and strongly associates with type 2 diabetes. Knowledge of biological pathways implicated in FLD is limited. An untargeted metabolomic approach might unravel novel pathways...

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Veröffentlicht in:	European journal of clinical nutrition 2017-08, Vol.71 (8), p.995-1001
Hauptverfasser:	Koch, M, Freitag-Wolf, S, Schlesinger, S, Borggrefe, J, Hov, J R, Jensen, M K, Pick, J, Markus, M R P, Höpfner, T, Jacobs, G, Siegert, S, Artati, A, Kastenmüller, G, Römisch-Margl, W, Adamski, J, Illig, T, Nothnagel, M, Karlsen, T H, Schreiber, S, Franke, A, Krawczak, M, Nöthlings, U, Lieb, W
Format:	Artikel
Sprache:	eng
Schlagworte:	101/58 59/36 692/53 692/699/2743/2037 Age Aged Alcohol Drinking - adverse effects Amino acids Biological Specimen Banks Biomarkers - blood Care and treatment Chain branching Clinical Nutrition Cohort Studies Computational Biology Confidence intervals Cross-Sectional Studies Development and progression Diabetes mellitus Diabetes mellitus (non-insulin dependent) Diagnosis Dipeptides - blood Epidemiology Expert Systems Fatty liver Fatty Liver, Alcoholic - blood Fatty Liver, Alcoholic - diagnostic imaging Fatty Liver, Alcoholic - metabolism Fatty Liver, Alcoholic - physiopathology Female Glutamic Acid - analogs & derivatives Glutamic Acid - blood Health aspects Humans Internal Medicine Least squares method Lipid Metabolism Liver Liver - diagnostic imaging Liver - metabolism Liver - physiopathology Liver diseases Magnetic Resonance Imaging Male Medicine Medicine & Public Health Metabolic Diseases Metabolites Metabolomics Metabolomics - methods Middle Aged Non-alcoholic Fatty Liver Disease - blood Non-alcoholic Fatty Liver Disease - diagnostic imaging Non-alcoholic Fatty Liver Disease - metabolism original-article Physical activity Physiological aspects Projection Public Health Regression analysis Regression models Robustness (mathematics) Sampling methods Self Report Severity of Illness Index Smoking Statistical analysis
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