Arterial aging mediates the effect of TNF-α and ACE polymorphisms on mental health in elderly individuals: insights from IKARIA study

Aging is characterized by an insidious decline in cognitive function. Several genetic and lifestyle factors have been implicated in the increased risk or early onset of dementia. We sought to assess the role of tumor necrosis factor (TNF) and angiotensin-converting enzyme (ACE) polymorphisms on the...

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Veröffentlicht in:	QJM : An International Journal of Medicine 2017-09, Vol.110 (9), p.551-557
Hauptverfasser:	Georgiopoulos, G, Chrysohoou, C, Errigo, A, Pes, G, Metaxa, V, Zaromytidou, M, Skoumas, J, Kariori, M, Lazaros, G, Vogiatzi, G, Poulain, M, Tousoulis, D, Pitsavos, C, Stefanadis, C
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Alzheimer Disease - diagnosis Alzheimer Disease - epidemiology Alzheimer Disease - genetics Aorta - diagnostic imaging Aorta - pathology Cellular Senescence - physiology Cognition - physiology Echocardiography - methods Endothelium, Vascular - pathology Female Gene Frequency Greece - epidemiology Humans Life Style Male Mental Status and Dementia Tests Peptidyl-Dipeptidase A - genetics Polymorphism, Genetic Risk Factors Tumor Necrosis Factor-alpha - genetics
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