NLRP3 inflammasome induced liver graft injury through activation of telomere‐independent RAP1/KC axis

Acute‐phase inflammation plays a critical role in liver graft injury. Inflammasomes, multi‐molecular complexes in the cytoplasm, are responsible for initiating inflammation. Here, we aimed to explore the role of inflammasomes in liver graft injury and further to investigate the regulatory mechanism....

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of pathology 2017-07, Vol.242 (3), p.284-296
Hauptverfasser:	Liu, Hui, Lo, Chung Mau, Yeung, Oscar Wai Ho, Li, Chang Xian, Liu, Xiao Bing, Qi, Xiang, Ng, Kevin Tak Pan, Liu, Jiang, Ma, Yuen Yuen, Lam, Yin Fan, Lian, Qizhou, Chan, See Ching, Man, Kwan
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Activator protein 1 Acute Lung Injury - etiology Acute Lung Injury - metabolism Adult Aged Animals Cytokines - metabolism Cytoplasm Disease Models, Animal Female Gene Knockdown Techniques Grafting Hepatectomy Hepatectomy - methods Humans Inflammasomes Inflammasomes - metabolism Inflammation Interleukin 1 Ischemia Leukocytes (neutrophilic) Liver Liver Transplantation Male Mice Mice, Inbred C57BL Middle Aged mRNA neutrophil Neutrophils Neutrophils - metabolism NLR Family, Pyrin Domain-Containing 3 Protein - metabolism Oligomerization Pyrin protein RAP1 rap1 GTP-Binding Proteins - deficiency rap1 GTP-Binding Proteins - metabolism Rap1 protein Regulators Reperfusion Reperfusion Injury - metabolism Rodents Telomere-Binding Proteins - metabolism Transplantation Transplants & implants Up-Regulation - physiology Upstream Urea Young Adult
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!