Germline Mutations in the Kallikrein 6 Region and Predisposition for Aggressive Prostate Cancer

There is a need for markers that can specifically identify individuals at increased risk of harboring aggressive forms of prostate cancer (PCa). We surveyed the Kallikrein ( KLK ) region ( KLK 1-15) for single-nucleotide polymorphisms (SNPs) associated with aggressive PCa (Gleason Score ≥ 8) in 1858...

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Veröffentlicht in:	JNCI : Journal of the National Cancer Institute 2017-04, Vol.109 (4)
Hauptverfasser:	Briollais, Laurent, Ozcelik, Hilmi, Xu, Jingxiong, Kwiatkowski, Maciej, Lalonde, Emilie, Sendorek, Dorota H, Fleshner, Neil E, Recker, Franz, Kuk, Cynthia, Olkhov-Mitsel, Ekaterina, Savas, Sevtap, Hanna, Sally, Juvet, Tristan, Hunter, Geoffrey A, Friedlander, Matt, Li, Hong, Chadwick, Karen, Prassas, Ioannis, Soosaipillai, Antoninus, Randazzo, Marco, Trachtenberg, John, Toi, Ants, Shiah, Yu-Jia, Fraser, Michael, van der Kwast, Theodorus, Bristow, Robert G, Bapat, Bharati, Diamandis, Eleftherios P, Boutros, Paul C, Zlotta, Alexandre R
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Chromosome Mapping Disease-Free Survival Genetic Predisposition to Disease Germ-Line Mutation Haplotypes Humans Kallikreins - genetics Male Middle Aged Neoplasm Grading Polymorphism, Single Nucleotide Prostatic Neoplasms - genetics Prostatic Neoplasms - pathology
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