Synthesis, Anti‐Inflammatory Activity, and COX‐1/2 Inhibition Profile of Some Novel Non‐Acidic Polysubstituted Pyrazoles and Pyrano[2,3‐c]pyrazoles

The synthesis and evaluation of the anti‐inflammatory activity of some structure hybrids comprising basically the 5‐hydroxy‐3‐methyl‐1‐phenyl‐4‐substituted‐1H‐pyrazole scaffold directly linked to a variety of heterocycles and functionalities, or annulated as pyrano[2,3‐c]pyrazoles, is described. Acc...

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Veröffentlicht in:	Archiv der Pharmazie (Weinheim) 2017-05, Vol.350 (5), p.n/a
Hauptverfasser:	Faidallah, Hassan M., Rostom, Sherif A. F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents, Non-Steroidal - chemical synthesis Anti-Inflammatory Agents, Non-Steroidal - chemistry Anti-Inflammatory Agents, Non-Steroidal - pharmacology Anti‐inflammatory activity Carrageenan COX‐1 COX‐2 Cyclooxygenase 1 - metabolism Cyclooxygenase 2 - metabolism Cyclooxygenase Inhibitors - chemical synthesis Cyclooxygenase Inhibitors - chemistry Cyclooxygenase Inhibitors - pharmacology Dose-Response Relationship, Drug Edema - chemically induced Edema - drug therapy Molecular Structure Pyrazole Pyrazoles - chemical synthesis Pyrazoles - chemistry Pyrazoles - pharmacology Rats Selective COX‐2 inhibitors Sheep Stomach Ulcer - drug therapy Structure-Activity Relationship
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