Characteristics and Impacts of Venous Thromboembolism in Patients with Hepatocellular Carcinoma
Introduction Venous thromboembolism (VTE) is a common complication in cancer patients, and is associated with worse prognosis in such population. Hepatocellular carcinoma (HCC) poses high risk for VTE; however, data is scarce regarding the characteristics and consequences of VTE in HCC patients. Met...
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| Veröffentlicht in: | Journal of gastrointestinal cancer 2018-09, Vol.49 (3), p.275-282 |
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| container_title | Journal of gastrointestinal cancer |
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| creator | Wang, Yuchen Attar, B. M. Hinami, K. Fuentes, H. E. Jaiswal, P. Zhang, H. Simons-Linares, C. S. Tafur, A. J. |
| description | Introduction
Venous thromboembolism (VTE) is a common complication in cancer patients, and is associated with worse prognosis in such population. Hepatocellular carcinoma (HCC) poses high risk for VTE; however, data is scarce regarding the characteristics and consequences of VTE in HCC patients.
Method
We retrospectively reviewed the electronic medical records (EMR) of 270 patients diagnosed with HCC from 2000 to 2015 in Cook County Health and Hospitals System. We report the cumulative incidence of VTE in the present cohort, and identified through multivariate logistic regression the independent risk factors of the development of VTE. Overall prognosis of patients with and without VTE were presented and compared.
Results
Sixteen cases (5.93%) of VTE were documented in the present study. In multivariate analysis, obesity, Child B cirrhosis, intra-hepatic lesions more than 3, and multi-organ extrahepatic metastasis were significantly associated with VTE development (
p
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| doi_str_mv | 10.1007/s12029-017-9945-6 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1884168558</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1884168558</sourcerecordid><originalsourceid>FETCH-LOGICAL-c344t-b00a0b2c34107f8b95d9d7b4fdc1901bd203d634d08ec0e762acde8d3d502e263</originalsourceid><addsrcrecordid>eNp9kEFPwyAUx4nRuDn9AF4MRy_VB6WUHs2ibomJHqZXQoE6lrZMaGP89rJs7uiBAI8f_7z3Q-iawB0BKO8joUCrDEiZVRUrMn6CpqRiJOM856fHMxUTdBHjBoCzgpBzNKEiLxkt6RTJ-VoFpQcbXBycjlj1Bi-7bSpF7Bv8YXs_RrxaB9_V3qbVuthh1-M3NTjbJ-rbDWu8sFs1eG3bdmxVwHMVtOt9py7RWaPaaK8O-wy9Pz2u5ovs5fV5OX94yXTO2JDVAApqmi4EykbUVWEqU9asMZpUQGpDITc8ZwaE1WBLTpU2VpjcFEAt5fkM3e5zt8F_jTYOsnNx147qbRpAEiEY4aIoRELJHtXBxxhsI7fBdSr8SAJy51XuvcrkVe68yl38zSF-rDtrjj_-RCaA7oGYnvpPG-TGj6FPI_-T-gu4goRy</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1884168558</pqid></control><display><type>article</type><title>Characteristics and Impacts of Venous Thromboembolism in Patients with Hepatocellular Carcinoma</title><source>SpringerLink Journals - AutoHoldings</source><creator>Wang, Yuchen ; Attar, B. M. ; Hinami, K. ; Fuentes, H. E. ; Jaiswal, P. ; Zhang, H. ; Simons-Linares, C. S. ; Tafur, A. J.</creator><creatorcontrib>Wang, Yuchen ; Attar, B. M. ; Hinami, K. ; Fuentes, H. E. ; Jaiswal, P. ; Zhang, H. ; Simons-Linares, C. S. ; Tafur, A. J.</creatorcontrib><description>Introduction
Venous thromboembolism (VTE) is a common complication in cancer patients, and is associated with worse prognosis in such population. Hepatocellular carcinoma (HCC) poses high risk for VTE; however, data is scarce regarding the characteristics and consequences of VTE in HCC patients.
Method
We retrospectively reviewed the electronic medical records (EMR) of 270 patients diagnosed with HCC from 2000 to 2015 in Cook County Health and Hospitals System. We report the cumulative incidence of VTE in the present cohort, and identified through multivariate logistic regression the independent risk factors of the development of VTE. Overall prognosis of patients with and without VTE were presented and compared.
Results
Sixteen cases (5.93%) of VTE were documented in the present study. In multivariate analysis, obesity, Child B cirrhosis, intra-hepatic lesions more than 3, and multi-organ extrahepatic metastasis were significantly associated with VTE development (
p
< 0.05). The presence of VTE was an independent risk factor for mortality in multivariate analysis (HR = 3.62,
p
= 0.021), together with male gender, Child C cirrhosis, and extrahepatic metastasis.
Conclusions
Obesity, Child B cirrhosis, more intra-hepatic lesions, and multi-organ extrahepatic metastasis are associated with cancer-associated VTE. VTE will adversely affect the prognosis of patients with HCC; therefore, primary thromboprophylaxis may be warranted in such population.</description><identifier>ISSN: 1941-6628</identifier><identifier>EISSN: 1941-6636</identifier><identifier>DOI: 10.1007/s12029-017-9945-6</identifier><identifier>PMID: 28374272</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Cancer Research ; Gastroenterology ; Internal Medicine ; Medicine ; Medicine & Public Health ; Oncology ; Original Research ; Radiotherapy</subject><ispartof>Journal of gastrointestinal cancer, 2018-09, Vol.49 (3), p.275-282</ispartof><rights>Springer Science+Business Media New York 2017</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c344t-b00a0b2c34107f8b95d9d7b4fdc1901bd203d634d08ec0e762acde8d3d502e263</citedby><cites>FETCH-LOGICAL-c344t-b00a0b2c34107f8b95d9d7b4fdc1901bd203d634d08ec0e762acde8d3d502e263</cites><orcidid>0000-0002-6507-1438</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12029-017-9945-6$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12029-017-9945-6$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27923,27924,41487,42556,51318</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28374272$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Yuchen</creatorcontrib><creatorcontrib>Attar, B. M.</creatorcontrib><creatorcontrib>Hinami, K.</creatorcontrib><creatorcontrib>Fuentes, H. E.</creatorcontrib><creatorcontrib>Jaiswal, P.</creatorcontrib><creatorcontrib>Zhang, H.</creatorcontrib><creatorcontrib>Simons-Linares, C. S.</creatorcontrib><creatorcontrib>Tafur, A. J.</creatorcontrib><title>Characteristics and Impacts of Venous Thromboembolism in Patients with Hepatocellular Carcinoma</title><title>Journal of gastrointestinal cancer</title><addtitle>J Gastrointest Canc</addtitle><addtitle>J Gastrointest Cancer</addtitle><description>Introduction
Venous thromboembolism (VTE) is a common complication in cancer patients, and is associated with worse prognosis in such population. Hepatocellular carcinoma (HCC) poses high risk for VTE; however, data is scarce regarding the characteristics and consequences of VTE in HCC patients.
Method
We retrospectively reviewed the electronic medical records (EMR) of 270 patients diagnosed with HCC from 2000 to 2015 in Cook County Health and Hospitals System. We report the cumulative incidence of VTE in the present cohort, and identified through multivariate logistic regression the independent risk factors of the development of VTE. Overall prognosis of patients with and without VTE were presented and compared.
Results
Sixteen cases (5.93%) of VTE were documented in the present study. In multivariate analysis, obesity, Child B cirrhosis, intra-hepatic lesions more than 3, and multi-organ extrahepatic metastasis were significantly associated with VTE development (
p
< 0.05). The presence of VTE was an independent risk factor for mortality in multivariate analysis (HR = 3.62,
p
= 0.021), together with male gender, Child C cirrhosis, and extrahepatic metastasis.
Conclusions
Obesity, Child B cirrhosis, more intra-hepatic lesions, and multi-organ extrahepatic metastasis are associated with cancer-associated VTE. VTE will adversely affect the prognosis of patients with HCC; therefore, primary thromboprophylaxis may be warranted in such population.</description><subject>Cancer Research</subject><subject>Gastroenterology</subject><subject>Internal Medicine</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Oncology</subject><subject>Original Research</subject><subject>Radiotherapy</subject><issn>1941-6628</issn><issn>1941-6636</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp9kEFPwyAUx4nRuDn9AF4MRy_VB6WUHs2ibomJHqZXQoE6lrZMaGP89rJs7uiBAI8f_7z3Q-iawB0BKO8joUCrDEiZVRUrMn6CpqRiJOM856fHMxUTdBHjBoCzgpBzNKEiLxkt6RTJ-VoFpQcbXBycjlj1Bi-7bSpF7Bv8YXs_RrxaB9_V3qbVuthh1-M3NTjbJ-rbDWu8sFs1eG3bdmxVwHMVtOt9py7RWaPaaK8O-wy9Pz2u5ovs5fV5OX94yXTO2JDVAApqmi4EykbUVWEqU9asMZpUQGpDITc8ZwaE1WBLTpU2VpjcFEAt5fkM3e5zt8F_jTYOsnNx147qbRpAEiEY4aIoRELJHtXBxxhsI7fBdSr8SAJy51XuvcrkVe68yl38zSF-rDtrjj_-RCaA7oGYnvpPG-TGj6FPI_-T-gu4goRy</recordid><startdate>20180901</startdate><enddate>20180901</enddate><creator>Wang, Yuchen</creator><creator>Attar, B. M.</creator><creator>Hinami, K.</creator><creator>Fuentes, H. E.</creator><creator>Jaiswal, P.</creator><creator>Zhang, H.</creator><creator>Simons-Linares, C. S.</creator><creator>Tafur, A. J.</creator><general>Springer US</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-6507-1438</orcidid></search><sort><creationdate>20180901</creationdate><title>Characteristics and Impacts of Venous Thromboembolism in Patients with Hepatocellular Carcinoma</title><author>Wang, Yuchen ; Attar, B. M. ; Hinami, K. ; Fuentes, H. E. ; Jaiswal, P. ; Zhang, H. ; Simons-Linares, C. S. ; Tafur, A. J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c344t-b00a0b2c34107f8b95d9d7b4fdc1901bd203d634d08ec0e762acde8d3d502e263</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Cancer Research</topic><topic>Gastroenterology</topic><topic>Internal Medicine</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Oncology</topic><topic>Original Research</topic><topic>Radiotherapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Yuchen</creatorcontrib><creatorcontrib>Attar, B. M.</creatorcontrib><creatorcontrib>Hinami, K.</creatorcontrib><creatorcontrib>Fuentes, H. E.</creatorcontrib><creatorcontrib>Jaiswal, P.</creatorcontrib><creatorcontrib>Zhang, H.</creatorcontrib><creatorcontrib>Simons-Linares, C. S.</creatorcontrib><creatorcontrib>Tafur, A. J.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of gastrointestinal cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Yuchen</au><au>Attar, B. M.</au><au>Hinami, K.</au><au>Fuentes, H. E.</au><au>Jaiswal, P.</au><au>Zhang, H.</au><au>Simons-Linares, C. S.</au><au>Tafur, A. J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Characteristics and Impacts of Venous Thromboembolism in Patients with Hepatocellular Carcinoma</atitle><jtitle>Journal of gastrointestinal cancer</jtitle><stitle>J Gastrointest Canc</stitle><addtitle>J Gastrointest Cancer</addtitle><date>2018-09-01</date><risdate>2018</risdate><volume>49</volume><issue>3</issue><spage>275</spage><epage>282</epage><pages>275-282</pages><issn>1941-6628</issn><eissn>1941-6636</eissn><abstract>Introduction
Venous thromboembolism (VTE) is a common complication in cancer patients, and is associated with worse prognosis in such population. Hepatocellular carcinoma (HCC) poses high risk for VTE; however, data is scarce regarding the characteristics and consequences of VTE in HCC patients.
Method
We retrospectively reviewed the electronic medical records (EMR) of 270 patients diagnosed with HCC from 2000 to 2015 in Cook County Health and Hospitals System. We report the cumulative incidence of VTE in the present cohort, and identified through multivariate logistic regression the independent risk factors of the development of VTE. Overall prognosis of patients with and without VTE were presented and compared.
Results
Sixteen cases (5.93%) of VTE were documented in the present study. In multivariate analysis, obesity, Child B cirrhosis, intra-hepatic lesions more than 3, and multi-organ extrahepatic metastasis were significantly associated with VTE development (
p
< 0.05). The presence of VTE was an independent risk factor for mortality in multivariate analysis (HR = 3.62,
p
= 0.021), together with male gender, Child C cirrhosis, and extrahepatic metastasis.
Conclusions
Obesity, Child B cirrhosis, more intra-hepatic lesions, and multi-organ extrahepatic metastasis are associated with cancer-associated VTE. VTE will adversely affect the prognosis of patients with HCC; therefore, primary thromboprophylaxis may be warranted in such population.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>28374272</pmid><doi>10.1007/s12029-017-9945-6</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-6507-1438</orcidid></addata></record> |
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| title | Characteristics and Impacts of Venous Thromboembolism in Patients with Hepatocellular Carcinoma |
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