Bifunctional Oxo-Tethered Ruthenium Complex Catalyzed Asymmetric Transfer Hydrogenation of Aryl N‑Heteroaryl Ketones

Bifunctional Oxo-Tethered Ruthenium Complex Catalyzed Asymmetric Transfer Hydrogenation of Aryl N‑Heteroaryl Ketones

A facile asymmetric transfer hydrogenation of ortho-substituted aryl N-heteroaryl ketones and non-ortho-substituted N-oxide of aryl N-heteroaryl ketones using a readily available oxo-tethered ruthenium complex as a catalyst and sodium formate as a hydrogen source in an aqueous solution has been disc...

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Veröffentlicht in:Organic letters 2017-04, Vol.19 (8), p.2094-2097
Hauptverfasser: Wang, Baigui, Zhou, Haifeng, Lu, Guoren, Liu, Qixing, Jiang, Xiaolan
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container_issue 8
container_start_page 2094
container_title Organic letters
container_volume 19
creator Wang, Baigui
Zhou, Haifeng
Lu, Guoren
Liu, Qixing
Jiang, Xiaolan
description A facile asymmetric transfer hydrogenation of ortho-substituted aryl N-heteroaryl ketones and non-ortho-substituted N-oxide of aryl N-heteroaryl ketones using a readily available oxo-tethered ruthenium complex as a catalyst and sodium formate as a hydrogen source in an aqueous solution has been discovered. A variety of chiral aryl N-heteroaryl methanols were obtained with up to 99.9% ee.
doi_str_mv 10.1021/acs.orglett.7b00691
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title Bifunctional Oxo-Tethered Ruthenium Complex Catalyzed Asymmetric Transfer Hydrogenation of Aryl N‑Heteroaryl Ketones
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