Age-dependent down-regulation of hyperpolarization-activated cyclic nucleotide-gated channel 4 causes deterioration of canine sinoatrial node function

The activity of pacemaker cells in the sinoatrial node （SAN） is an indicator of normal sinus rhythm. Clinical studies have revealed that the dysfunction of the SAN progressively increases with aging, In this study, we determined the changes in hyperpolarization-activated cyclic nucleotide-gated chan...

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Veröffentlicht in:	Acta biochimica et biophysica Sinica 2017-05, Vol.49 (5), p.400-408
Hauptverfasser:	Du, Jianlin, Deng, Songbai, Pu, Di, Liu, Yajie, Xiao, Jun, She, Qiang
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging - metabolism Animals Dogs Down-Regulation Female Heart Conduction System - physiopathology Heart Rate Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels - metabolism Male Sinoatrial Node - physiopathology
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