Topical delivery of anthramycin I. Influence of neat solvents

Anthramycin (ANT) was the first pyrrolobenzodiazepine (PBD) molecule to be isolated, and is a potent cytotoxic agent. Although the PBD family has been investigated for use in systemic chemotherapy, their application in the management of actinic keratoses (AK) or skin cancer has not been investigated...

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Veröffentlicht in:	European journal of pharmaceutical sciences 2017-06, Vol.104, p.188-195
Hauptverfasser:	Haque, Tasnuva, Rahman, Khondaker M., Thurston, David E., Hadgraft, Jonathan, Lane, Majella E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Topical Anthramycin Anthramycin - administration & dosage Chromatography, Gas Chromatography, High Pressure Liquid Dose-Response Relationship, Drug Franz diffusion cell Humans PBDs Permeation Pyrrolobenzodiazepines Skin cancer Solvents Solvents - chemistry Topical therapy
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