FTY720 (fingolimod) regulates key target genes essential for inflammation in microglial cells as defined by high-resolution mRNA sequencing

Although microglial cells have an essential role in the host defense of the brain, the abnormal activation of microglia can lead to devastating outcomes, such as neuroinflammation and neurodegeneration. Emerging evidence indicates that FTY720 (fingolimod), an FDA-approved drug, has beneficial effect...

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Veröffentlicht in:	Neuropharmacology 2017-06, Vol.119, p.1-14
Hauptverfasser:	Das, Amitabh, Arifuzzaman, Sarder, Kim, Sun Hwa, Lee, Young Seek, Jung, Kyoung Hwa, Chai, Young Gyu
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn Cell Survival - drug effects Cells, Cultured Enzyme-Linked Immunosorbent Assay Fingolimod (FTY720) Fingolimod Hydrochloride - pharmacology Gene Expression Regulation - drug effects Immunosuppressive Agents - pharmacology IRF8/STAT1 pathway Lipopolysaccharides - pharmacology Mice Mice, Inbred ICR Microglia - drug effects Neuroinflammation RNA sequencing RNA, Messenger - metabolism Sequence Analysis, RNA Sphingosine 1-phosphate receptors (S1PRs) Transcription Factors - genetics Transcription Factors - metabolism
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