The mitochondrial apoptotic pathway is induced by Cu(II) antineoplastic compounds (Casiopeínas®) in SK-N-SH neuroblastoma cells after short exposure times

The family of Copper(II) coordination compounds Casiopeínas ® ( Cas ) has shown antiproliferative activity in several tumour lines by oxidative cellular damage and mitochondrial dysfunction that lead to cell death through apoptotic pathways. The goal of this work is looking for the functional mechan...

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Veröffentlicht in:	Biometals 2017-02, Vol.30 (1), p.43-58
Hauptverfasser:	Garcia-Ramos, Juan Carlos, Gutierrez, Anllely Grizett, Vazquez-Aguirre, Adriana, Toledano-Magana, Yanis, Alonso-Saenz, Ana Luisa, Gomez-Vidales, Virginia, Flores-Alamo, Marcos, Mejia, Carmen, Ruiz-Azuara, Lena
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - administration & dosage Antineoplastic Agents - chemistry Antiproliferatives Apoptosis Apoptosis - drug effects Biochemistry Biomedical and Life Sciences Carcinogenic agents Cell Biology Cell Line, Tumor Cisplatin - administration & dosage Cisplatin - chemistry Coordination compounds Copper Copper - chemistry Glutathione Humans Hydrogen peroxide Life Sciences Lymphocytes Medicine/Public Health Membrane Potential, Mitochondrial - drug effects Microbiology Mitochondria Mitochondria - drug effects Mitochondria - pathology Molecular structure Neuroblastoma - drug therapy Neuroblastoma - pathology Organometallic Compounds - administration & dosage Organometallic Compounds - chemistry Oxidation-Reduction Oxidative stress Oxidizing agents Paediatrics Pathways Pharmacology/Toxicology Plant Physiology Reactive Oxygen Species - metabolism Sulfur Tumors
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