In vitro kinetic study of the squalestatin tetraketide synthase dehydratase reveals the stereochemical course of a fungal highly reducing polyketide synthase

Six potential diketide substrates for the squalestatin tetraketide synthase (SQTKS) dehydratase (DH) domain were synthesised as N-acetyl cysteamine thiolesters (SNAC) and tested in kinetic assays as substrates with an isolated DH domain. 3R-3-hydroxybutyryl SNAC 3R-16 was turned over by the enzyme,...

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Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2017, Vol.53 (10), p.1727-1730
Hauptverfasser:	Liddle, Emma, Scott, Alan, Han, Li-Chen, Ivison, David, Simpson, Thomas J, Willis, Christine L, Cox, Russell J
Format:	Artikel
Sprache:	eng
Schlagworte:	Bridged Bicyclo Compounds, Heterocyclic - chemistry Bridged Bicyclo Compounds, Heterocyclic - metabolism Cyclohexanones - chemistry Cyclohexanones - metabolism Cysteamine Dehydration Disaccharides - chemistry Disaccharides - metabolism Enzymes Fatty acids Fungi Fungi - enzymology Hydro-Lyases - metabolism Kinetics Molecular Structure Polyketide Synthases - metabolism Stereoisomerism Substrates Synthesis Tricarboxylic Acids - chemistry Tricarboxylic Acids - metabolism Vertebrates
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