Palladium-catalyzed aerobic (1+2) annulation of Csp3-H bonds with olefin for the synthesis of 3-azabicyclo[3.1.0]hex-2-ene
A novel palladium-catalyzed aerobic (1+2) annulation was developed for the synthesis of 3-azabicyclo[3.1.0]hex-2-ene. The palladation of Csp3-H bonds took place twice at the same position in the whole reaction process. Preliminary mechanistic studies by in situ IR revealed that the second C-H pallad...
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| Veröffentlicht in: | Chemical communications (Cambridge, England) England), 2017-02, Vol.53 (14), p.2294-2297 |
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| container_issue | 14 |
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| container_title | Chemical communications (Cambridge, England) |
| container_volume | 53 |
| creator | Wu, Kun Meng, Lingkui Huai, Mingming Huang, Zhiliang Liu, Chao Qi, Xiaotian Lei, Aiwen |
| description | A novel palladium-catalyzed aerobic (1+2) annulation was developed for the synthesis of 3-azabicyclo[3.1.0]hex-2-ene. The palladation of Csp3-H bonds took place twice at the same position in the whole reaction process. Preliminary mechanistic studies by in situ IR revealed that the second C-H palladation and reductive elimination might be slow steps. |
| doi_str_mv | 10.1039/c6cc09332a |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 1359-7345 |
| ispartof | Chemical communications (Cambridge, England), 2017-02, Vol.53 (14), p.2294-2297 |
| issn | 1359-7345 1364-548X |
| language | eng |
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| source | Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| subjects | Chemical bonds Chemical reactions Olefins Organic chemistry Palladium Synthesis |
| title | Palladium-catalyzed aerobic (1+2) annulation of Csp3-H bonds with olefin for the synthesis of 3-azabicyclo[3.1.0]hex-2-ene |
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