Metal‐organic‐frameworks for biomedical applications in drug delivery, and as MRI contrast agents
The metal‐organic‐frameworks (MOFs) materials are increasingly gaining attraction to utilise into biomedical applications. MOFs are playing a major role to harnessing dual or multiple modalities in therapeutics and diagnostics. MOFs are mostly devised for particular biomedical application by post‐sy...
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| Veröffentlicht in: | Journal of biomedical materials research. Part A 2017-04, Vol.105 (4), p.1184-1194 |
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| container_title | Journal of biomedical materials research. Part A |
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| creator | Chowdhury, Mohammad A. |
| description | The metal‐organic‐frameworks (MOFs) materials are increasingly gaining attraction to utilise into biomedical applications. MOFs are playing a major role to harnessing dual or multiple modalities in therapeutics and diagnostics. MOFs are mostly devised for particular biomedical application by post‐synthetic functionalization or modification using variety of polymers, bio‐ligands, and silica coating processes. This article presents a brief overview of two particular areas of biomedical applications where a broad range of MOFs have been used: (1) variety of drug delivery including intracellular drug delivery systems using the MOFs‐based carriers; and, (2) development of MOFs‐based contrast agents for magnetic resonance image enhancement. Biocompatibility, bio‐toxicity, tissue responses, cell viability, cellular uptakes, and, how the effects of size, shape, structural, and morphological properties of the MOFs impact on the utilities in drug delivery and as MRI contrast agents, are discussed. Perspectives, insights and critical reflections into a range of aspects, and future outlook are illustrated. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 1184–1194, 2017. |
| doi_str_mv | 10.1002/jbm.a.35995 |
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MOFs are playing a major role to harnessing dual or multiple modalities in therapeutics and diagnostics. MOFs are mostly devised for particular biomedical application by post‐synthetic functionalization or modification using variety of polymers, bio‐ligands, and silica coating processes. This article presents a brief overview of two particular areas of biomedical applications where a broad range of MOFs have been used: (1) variety of drug delivery including intracellular drug delivery systems using the MOFs‐based carriers; and, (2) development of MOFs‐based contrast agents for magnetic resonance image enhancement. Biocompatibility, bio‐toxicity, tissue responses, cell viability, cellular uptakes, and, how the effects of size, shape, structural, and morphological properties of the MOFs impact on the utilities in drug delivery and as MRI contrast agents, are discussed. Perspectives, insights and critical reflections into a range of aspects, and future outlook are illustrated. © 2017 Wiley Periodicals, Inc. 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Part A</title><addtitle>J Biomed Mater Res A</addtitle><description>The metal‐organic‐frameworks (MOFs) materials are increasingly gaining attraction to utilise into biomedical applications. MOFs are playing a major role to harnessing dual or multiple modalities in therapeutics and diagnostics. MOFs are mostly devised for particular biomedical application by post‐synthetic functionalization or modification using variety of polymers, bio‐ligands, and silica coating processes. This article presents a brief overview of two particular areas of biomedical applications where a broad range of MOFs have been used: (1) variety of drug delivery including intracellular drug delivery systems using the MOFs‐based carriers; and, (2) development of MOFs‐based contrast agents for magnetic resonance image enhancement. Biocompatibility, bio‐toxicity, tissue responses, cell viability, cellular uptakes, and, how the effects of size, shape, structural, and morphological properties of the MOFs impact on the utilities in drug delivery and as MRI contrast agents, are discussed. Perspectives, insights and critical reflections into a range of aspects, and future outlook are illustrated. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 1184–1194, 2017.</description><subject>Animals</subject><subject>Biomedical materials</subject><subject>Biomimetic Materials - chemistry</subject><subject>Biomimetic Materials - therapeutic use</subject><subject>bio‐toxicity</subject><subject>Contrast agents</subject><subject>Contrast Media - chemistry</subject><subject>Contrast Media - therapeutic use</subject><subject>Drug Carriers - chemistry</subject><subject>Drug Carriers - therapeutic use</subject><subject>drug delivery</subject><subject>Drug delivery systems</subject><subject>Humans</subject><subject>Magnetic resonance</subject><subject>Magnetic resonance imaging</subject><subject>Metals - chemistry</subject><subject>Metals - therapeutic use</subject><subject>metal‐organic‐frameworks</subject><subject>Reflection</subject><subject>relaxivity</subject><subject>Surgical implants</subject><subject>Viability</subject><issn>1549-3296</issn><issn>1552-4965</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkUFv1DAQhS1URMvCiXtlqRcOZLE9tuMc2xWFoq6QEJyt2cRZeUniYCet9tafwG_sL2myLT1w4jRPmk8zeu8R8o6zJWdMfNxt2iUuQRWFekFOuFIik4VWR7OWRQai0MfkdUq7CdZMiVfkWBgGoBWcELd2Azb3d39C3GLny0nVEVt3G-KvROsQ6caH1lW-xIZi3zeTGHzoEvUdreK4pZVr_I2L-w8Uu4piouvvV7QM3RAxDRS3rhvSG_Kyxia5t09zQX5efvqx-pJdf_t8tTq_znqQRmUVGFEpDsaUNeOidtrkWBZCbFytudEVCgW6UKWEyYDUoPNclpWSAMAAFSzI-8e7fQy_R5cG2_pUuqbBzoUxWW6M5EzpHP4DzXPDNdMzevYPugtj7CYjMyVYLoWYf58-UeNmCsz20bcY9_Zv1hMgHoFb37j9854zO9dopxot2kON9uvF-vyg4AF3T4_V</recordid><startdate>201704</startdate><enddate>201704</enddate><creator>Chowdhury, Mohammad A.</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7QF</scope><scope>7QO</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7TA</scope><scope>7TB</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>JG9</scope><scope>JQ2</scope><scope>K9.</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>P64</scope></search><sort><creationdate>201704</creationdate><title>Metal‐organic‐frameworks for biomedical applications in drug delivery, and as MRI contrast agents</title><author>Chowdhury, Mohammad A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p3485-d382d51388cf012fe687ac922bef6186da253695c438034636774cd5433303a53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Animals</topic><topic>Biomedical materials</topic><topic>Biomimetic Materials - chemistry</topic><topic>Biomimetic Materials - therapeutic use</topic><topic>bio‐toxicity</topic><topic>Contrast agents</topic><topic>Contrast Media - chemistry</topic><topic>Contrast Media - therapeutic use</topic><topic>Drug Carriers - chemistry</topic><topic>Drug Carriers - therapeutic use</topic><topic>drug delivery</topic><topic>Drug delivery systems</topic><topic>Humans</topic><topic>Magnetic resonance</topic><topic>Magnetic resonance imaging</topic><topic>Metals - chemistry</topic><topic>Metals - therapeutic use</topic><topic>metal‐organic‐frameworks</topic><topic>Reflection</topic><topic>relaxivity</topic><topic>Surgical implants</topic><topic>Viability</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chowdhury, Mohammad A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Aluminium Industry Abstracts</collection><collection>Biotechnology Research Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Civil Engineering Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Journal of biomedical materials research. 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MOFs are mostly devised for particular biomedical application by post‐synthetic functionalization or modification using variety of polymers, bio‐ligands, and silica coating processes. This article presents a brief overview of two particular areas of biomedical applications where a broad range of MOFs have been used: (1) variety of drug delivery including intracellular drug delivery systems using the MOFs‐based carriers; and, (2) development of MOFs‐based contrast agents for magnetic resonance image enhancement. Biocompatibility, bio‐toxicity, tissue responses, cell viability, cellular uptakes, and, how the effects of size, shape, structural, and morphological properties of the MOFs impact on the utilities in drug delivery and as MRI contrast agents, are discussed. Perspectives, insights and critical reflections into a range of aspects, and future outlook are illustrated. © 2017 Wiley Periodicals, Inc. 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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Animals Biomedical materials Biomimetic Materials - chemistry Biomimetic Materials - therapeutic use bio‐toxicity Contrast agents Contrast Media - chemistry Contrast Media - therapeutic use Drug Carriers - chemistry Drug Carriers - therapeutic use drug delivery Drug delivery systems Humans Magnetic resonance Magnetic resonance imaging Metals - chemistry Metals - therapeutic use metal‐organic‐frameworks Reflection relaxivity Surgical implants Viability |
| title | Metal‐organic‐frameworks for biomedical applications in drug delivery, and as MRI contrast agents |
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