Rapid concentration detection and differentiation of bacteria in skimmed milk using surface enhanced Raman scattering mapping on 4-mercaptophenylboronic acid functionalized silver dendrites
A novel method was developed to rapidly concentrate, detect, and differentiate bacteria in skimmed milk using surface enhanced Raman scattering (SERS) mapping on 4-mercaptophenylboronic acid (4-MPBA) functionalized silver (Ag) dendrites. The 4-MPBA functionalized Ag dendritic SERS substrate was used...
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| Veröffentlicht in: | Analytical and bioanalytical chemistry 2017-03, Vol.409 (8), p.2229-2238 |
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| container_title | Analytical and bioanalytical chemistry |
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| creator | Wang, Panxue Pang, Shintaro Pearson, Brooke Chujo, Yayoi McLandsborough, Lynne Fan, Mingtao He, Lili |
| description | A novel method was developed to rapidly concentrate, detect, and differentiate bacteria in skimmed milk using surface enhanced Raman scattering (SERS) mapping on 4-mercaptophenylboronic acid (4-MPBA) functionalized silver (Ag) dendrites. The 4-MPBA functionalized Ag dendritic SERS substrate was used to capture the bacterial cells and enhance the bacterial signal.
Salmonella
, a significantly important food pathogen, was used as the representative strain to optimize and evaluate the developed method. The capture efficiency for
Salmonella enterica
subsp
enterica
BAA1045 (SE1045) was 84.92 ± 3.25% at 10
6
CFU/mL and as high as 99.65 ± 3.58% at 10
3
CFU/mL. Four different strains, two gram-negative and two gram-positive, can be clearly distinguished by their SERS spectra using principle component analysis. A mapping technique was utilized to automatically collect 400 spectra over an area of 60 μm × 60 μm to construct a visual image for a sensitive and statistically reliable detection within 30 min. Using this method, we were able to detect as low as 10
3
CFU/mL bacterial cells in 50 mM NH
4
HCO
3
solution and 10
2
CFU/mL cells in both 1% casein and skimmed milk. Our results demonstrate the feasibility of using SERS mapping method coupled with 4-MPBA functionalized Ag dendrites for rapid and sensitive bacteria detection in complex liquid samples.
Graphical Abstract
A novel SERS mapping method based on 4-mercaptophenylboronic acid functionalized silver (Ag) dendrites was developed to rapidly concentrate, detect, and differentiate bacteria |
| doi_str_mv | 10.1007/s00216-016-0167-8 |
| format | Article |
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Salmonella
, a significantly important food pathogen, was used as the representative strain to optimize and evaluate the developed method. The capture efficiency for
Salmonella enterica
subsp
enterica
BAA1045 (SE1045) was 84.92 ± 3.25% at 10
6
CFU/mL and as high as 99.65 ± 3.58% at 10
3
CFU/mL. Four different strains, two gram-negative and two gram-positive, can be clearly distinguished by their SERS spectra using principle component analysis. A mapping technique was utilized to automatically collect 400 spectra over an area of 60 μm × 60 μm to construct a visual image for a sensitive and statistically reliable detection within 30 min. Using this method, we were able to detect as low as 10
3
CFU/mL bacterial cells in 50 mM NH
4
HCO
3
solution and 10
2
CFU/mL cells in both 1% casein and skimmed milk. Our results demonstrate the feasibility of using SERS mapping method coupled with 4-MPBA functionalized Ag dendrites for rapid and sensitive bacteria detection in complex liquid samples.
Graphical Abstract
A novel SERS mapping method based on 4-mercaptophenylboronic acid functionalized silver (Ag) dendrites was developed to rapidly concentrate, detect, and differentiate bacteria</description><identifier>ISSN: 1618-2642</identifier><identifier>EISSN: 1618-2650</identifier><identifier>DOI: 10.1007/s00216-016-0167-8</identifier><identifier>PMID: 28091716</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Analytical Chemistry ; Bacteria ; Biochemistry ; Characterization and Evaluation of Materials ; Chemistry ; Chemistry and Materials Science ; Contamination ; Dendrites ; Dendritic structure ; Electromagnetism ; Ethanol ; Food Science ; Identification and classification ; Laboratory Medicine ; Mapping ; Measurement ; Methods ; Milk ; Monitoring/Environmental Analysis ; Principal components analysis ; Raman scattering ; Raman spectroscopy ; Research Paper ; Salmonella ; Silver ; Skim milk ; Spectra ; Spectrum analysis</subject><ispartof>Analytical and bioanalytical chemistry, 2017-03, Vol.409 (8), p.2229-2238</ispartof><rights>Springer-Verlag Berlin Heidelberg 2017</rights><rights>COPYRIGHT 2017 Springer</rights><rights>Analytical and Bioanalytical Chemistry is a copyright of Springer, 2017.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c514t-7d08590a064a52dd2603b72fed88986c0f6daa531447a68309e9ea41affc3c483</citedby><cites>FETCH-LOGICAL-c514t-7d08590a064a52dd2603b72fed88986c0f6daa531447a68309e9ea41affc3c483</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00216-016-0167-8$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00216-016-0167-8$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28091716$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Panxue</creatorcontrib><creatorcontrib>Pang, Shintaro</creatorcontrib><creatorcontrib>Pearson, Brooke</creatorcontrib><creatorcontrib>Chujo, Yayoi</creatorcontrib><creatorcontrib>McLandsborough, Lynne</creatorcontrib><creatorcontrib>Fan, Mingtao</creatorcontrib><creatorcontrib>He, Lili</creatorcontrib><title>Rapid concentration detection and differentiation of bacteria in skimmed milk using surface enhanced Raman scattering mapping on 4-mercaptophenylboronic acid functionalized silver dendrites</title><title>Analytical and bioanalytical chemistry</title><addtitle>Anal Bioanal Chem</addtitle><addtitle>Anal Bioanal Chem</addtitle><description>A novel method was developed to rapidly concentrate, detect, and differentiate bacteria in skimmed milk using surface enhanced Raman scattering (SERS) mapping on 4-mercaptophenylboronic acid (4-MPBA) functionalized silver (Ag) dendrites. The 4-MPBA functionalized Ag dendritic SERS substrate was used to capture the bacterial cells and enhance the bacterial signal.
Salmonella
, a significantly important food pathogen, was used as the representative strain to optimize and evaluate the developed method. The capture efficiency for
Salmonella enterica
subsp
enterica
BAA1045 (SE1045) was 84.92 ± 3.25% at 10
6
CFU/mL and as high as 99.65 ± 3.58% at 10
3
CFU/mL. Four different strains, two gram-negative and two gram-positive, can be clearly distinguished by their SERS spectra using principle component analysis. A mapping technique was utilized to automatically collect 400 spectra over an area of 60 μm × 60 μm to construct a visual image for a sensitive and statistically reliable detection within 30 min. Using this method, we were able to detect as low as 10
3
CFU/mL bacterial cells in 50 mM NH
4
HCO
3
solution and 10
2
CFU/mL cells in both 1% casein and skimmed milk. Our results demonstrate the feasibility of using SERS mapping method coupled with 4-MPBA functionalized Ag dendrites for rapid and sensitive bacteria detection in complex liquid samples.
Graphical Abstract
A novel SERS mapping method based on 4-mercaptophenylboronic acid functionalized silver (Ag) dendrites was developed to rapidly concentrate, detect, and differentiate bacteria</description><subject>Analytical Chemistry</subject><subject>Bacteria</subject><subject>Biochemistry</subject><subject>Characterization and Evaluation of Materials</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Contamination</subject><subject>Dendrites</subject><subject>Dendritic structure</subject><subject>Electromagnetism</subject><subject>Ethanol</subject><subject>Food Science</subject><subject>Identification and classification</subject><subject>Laboratory Medicine</subject><subject>Mapping</subject><subject>Measurement</subject><subject>Methods</subject><subject>Milk</subject><subject>Monitoring/Environmental Analysis</subject><subject>Principal components analysis</subject><subject>Raman scattering</subject><subject>Raman spectroscopy</subject><subject>Research Paper</subject><subject>Salmonella</subject><subject>Silver</subject><subject>Skim milk</subject><subject>Spectra</subject><subject>Spectrum 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classification</topic><topic>Laboratory Medicine</topic><topic>Mapping</topic><topic>Measurement</topic><topic>Methods</topic><topic>Milk</topic><topic>Monitoring/Environmental Analysis</topic><topic>Principal components analysis</topic><topic>Raman scattering</topic><topic>Raman spectroscopy</topic><topic>Research Paper</topic><topic>Salmonella</topic><topic>Silver</topic><topic>Skim milk</topic><topic>Spectra</topic><topic>Spectrum analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Panxue</creatorcontrib><creatorcontrib>Pang, Shintaro</creatorcontrib><creatorcontrib>Pearson, Brooke</creatorcontrib><creatorcontrib>Chujo, Yayoi</creatorcontrib><creatorcontrib>McLandsborough, Lynne</creatorcontrib><creatorcontrib>Fan, Mingtao</creatorcontrib><creatorcontrib>He, Lili</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Aluminium Industry 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4-mercaptophenylboronic acid functionalized silver dendrites</atitle><jtitle>Analytical and bioanalytical chemistry</jtitle><stitle>Anal Bioanal Chem</stitle><addtitle>Anal Bioanal Chem</addtitle><date>2017-03-01</date><risdate>2017</risdate><volume>409</volume><issue>8</issue><spage>2229</spage><epage>2238</epage><pages>2229-2238</pages><issn>1618-2642</issn><eissn>1618-2650</eissn><abstract>A novel method was developed to rapidly concentrate, detect, and differentiate bacteria in skimmed milk using surface enhanced Raman scattering (SERS) mapping on 4-mercaptophenylboronic acid (4-MPBA) functionalized silver (Ag) dendrites. The 4-MPBA functionalized Ag dendritic SERS substrate was used to capture the bacterial cells and enhance the bacterial signal.
Salmonella
, a significantly important food pathogen, was used as the representative strain to optimize and evaluate the developed method. The capture efficiency for
Salmonella enterica
subsp
enterica
BAA1045 (SE1045) was 84.92 ± 3.25% at 10
6
CFU/mL and as high as 99.65 ± 3.58% at 10
3
CFU/mL. Four different strains, two gram-negative and two gram-positive, can be clearly distinguished by their SERS spectra using principle component analysis. A mapping technique was utilized to automatically collect 400 spectra over an area of 60 μm × 60 μm to construct a visual image for a sensitive and statistically reliable detection within 30 min. Using this method, we were able to detect as low as 10
3
CFU/mL bacterial cells in 50 mM NH
4
HCO
3
solution and 10
2
CFU/mL cells in both 1% casein and skimmed milk. Our results demonstrate the feasibility of using SERS mapping method coupled with 4-MPBA functionalized Ag dendrites for rapid and sensitive bacteria detection in complex liquid samples.
Graphical Abstract
A novel SERS mapping method based on 4-mercaptophenylboronic acid functionalized silver (Ag) dendrites was developed to rapidly concentrate, detect, and differentiate bacteria</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>28091716</pmid><doi>10.1007/s00216-016-0167-8</doi><tpages>10</tpages></addata></record> |
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| ispartof | Analytical and bioanalytical chemistry, 2017-03, Vol.409 (8), p.2229-2238 |
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| source | SpringerLink Journals - AutoHoldings |
| subjects | Analytical Chemistry Bacteria Biochemistry Characterization and Evaluation of Materials Chemistry Chemistry and Materials Science Contamination Dendrites Dendritic structure Electromagnetism Ethanol Food Science Identification and classification Laboratory Medicine Mapping Measurement Methods Milk Monitoring/Environmental Analysis Principal components analysis Raman scattering Raman spectroscopy Research Paper Salmonella Silver Skim milk Spectra Spectrum analysis |
| title | Rapid concentration detection and differentiation of bacteria in skimmed milk using surface enhanced Raman scattering mapping on 4-mercaptophenylboronic acid functionalized silver dendrites |
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