Rhodium‐Catalyzed Asymmetric Hydrogenation of Tetrasubstituted Cyclic Enamides: Efficient Access to Chiral Cycloalkylamine Derivatives

An efficient rhodium‐catalyzed asymmetric hydrogenation of challenging tetrasubstituted cyclic enamides has been developed, affording cyclic chiral amides with high yields and excellent enantioselectivities (up to 99% yield and >99% ee). This novel methodology provides an efficient and concise sy...

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Veröffentlicht in:	Advanced synthesis & catalysis 2017-02, Vol.359 (4), p.597-602
Hauptverfasser:	Li, Xiuxiu, You, Cai, Yang, Hailong, Che, Jinteng, Chen, Pengyu, Yang, Yusheng, Lv, Hui, Zhang, Xumu
Format:	Artikel
Sprache:	eng
Schlagworte:	Amides amines asymmetric synthesis Asymmetry Biocompatibility Biomedical materials Catalysis Chemical synthesis Derivatives enantioselectivity Hydrogenation Rhodium Surgical implants Synthesis (chemistry) Utilities
Online-Zugang:	Volltext
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