Host-guest kinetic interactions between HP-β-cyclodextrin and drugs for prediction of bitter taste masking

[Display omitted] •The relationship between kinetic parameter (Ka and Kd) of drug-cyclodextrin inclusion and taste masking is revealed.•A 3D model is successfully established to predict taste masking effect of drug-cyclodextrin inclusion.•A novel and high-throughput method based on SPRi is developed...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Journal of pharmaceutical and biomedical analysis 2017-06, Vol.140, p.232-238
Hauptverfasser:	Guo, Zhen, Wu, Fei, Singh, Vikramjeet, Guo, Tao, Ren, Xiaohong, Yin, Xianzhen, Shao, Qun, York, Peter, Patterson, Laurence H., Zhang, Jiwen
Format:	Artikel
Sprache:	eng
Schlagworte:	2-Hydroxypropyl-beta-cyclodextrin Cyclodextrin Kinetic parameters Kinetics Modeling Prediction Reproducibility of Results Surface plasmon resonance imaging Taste Taste masking
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!