Hydrogel containing silibinin-loaded pomegranate oil based nanocapsules exhibits anti-inflammatory effects on skin damage UVB radiation-induced in mice

The present study shows the development of a topical formulation (hydrogel) containing silibinin-loaded pomegranate oil based nanocapsules suspension and its evaluation as an alternative for the treatment of cutaneous UVB radiation-induced damages. For this, an animal model of skin injury induced by...

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Veröffentlicht in:	Journal of photochemistry and photobiology. B, Biology Biology, 2017-05, Vol.170, p.25-32
Hauptverfasser:	Marchiori, Marila Crivellaro Lay, Rigon, Cristina, Camponogara, Camila, Oliveira, Sara Marchesan, Cruz, Letícia
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-inflammatory agents Anti-Inflammatory Agents - chemistry Anti-Inflammatory Agents - therapeutic use Antibiotics Burns Cells Diffusion cells Ear Edema Edema - drug therapy Edema - metabolism Edema - pathology Feasibility studies Formulations Gellan gum Hydrogel, Polyethylene Glycol Dimethacrylate - chemistry Hydrogels Hydrogen-Ion Concentration Infiltration Inflammation Male Mice Nanocapsules - chemistry Nanoparticles Oil Oils & fats Peroxidase - metabolism pH effects Photodamage Plant Oils - chemistry Punicaceae - chemistry Punicaceae - metabolism Radiation Radiation damage Radiation effects Radiation injuries Reagents Semisolid formulation Semisolids Silibinin Silver Silver Sulfadiazine - therapeutic use Silymarin Silymarin - chemistry Silymarin - therapeutic use Skin Skin - metabolism Skin - pathology Skin - radiation effects Skin injuries Sulfadiazine Ultraviolet radiation Ultraviolet Rays UVB Vegetable oil
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