Intramuscularly administered herpes zoster subunit vaccine has no effects on fertility, pre- and post-natal development in Sprague-Dawley rats

•An investigational shingles vaccine (gE/AS01) is under development.•Potential developmental and reproductive toxic effects were assessed in rats.•Female fertility, fetal and offspring development were unaffected by the vaccine.•Male mating performance and fertility were unaffected by the vaccine. T...

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Veröffentlicht in:	Reproductive toxicology (Elmsford, N.Y.) N.Y.), 2017-04, Vol.69, p.297-307
Hauptverfasser:	Segal, Lawrence, Thacker, Karen, Fochesato, Michel, Giordano, Giulia, Garçon, Nathalie, Destexhe, Eric
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals AS01 Embryonic Development - drug effects Female Fertility - drug effects Fetal Development - drug effects Herpes Zoster Vaccine - administration & dosage Injections, Intramuscular Lactation Male Pregnancy Rat Rats, Sprague-Dawley Reproduction - drug effects Reproductive toxicology Vaccine Vaccines, Subunit - administration & dosage Zoster
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